CRCGN008_HEPG2_24H:P12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN008_HEPG2_24H:P12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.16725
CIAO3 cytosolic iron-sulfur assembly component 3 5.05795
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.8343
UBQLN2 ubiquilin 2 4.6572
E2F2 E2F transcription factor 2 4.4135
GSTZ1 glutathione S-transferase zeta 1 4.30575
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.29265
EGF epidermal growth factor 4.20395
CD40 CD40 molecule, TNF receptor superfamily member 5 4.01622
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.91635
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.57595
PLSCR1 phospholipid scramblase 1 3.27135
JADE2 jade family PHD finger 2 2.98795
GPATCH8 G patch domain containing 8 2.9796
CCNA1 cyclin A1 2.92525
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.88875
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.72285
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.62125
ICAM1 intercellular adhesion molecule 1 2.56095
EBI3 Epstein-Barr virus induced 3 2.5416
DNASE1 deoxyribonuclease I 2.45345
E2F6 E2F transcription factor 6 2.4029
MAGEA4 melanoma antigen family A4 2.2972
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.2726
KLHDC2 kelch domain containing 2 2.26615
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.26205
ADGRB1 adhesion G protein-coupled receptor B1 2.2304
PLCL1 phospholipase C-like 1 2.213
CYCS cytochrome c, somatic 2.19795
MCRS1 microspherule protein 1 2.19135
EPHA3 EPH receptor A3 2.18063
BPHL biphenyl hydrolase-like (serine hydrolase) 2.17155
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.163
RHCG Rh family, C glycoprotein 2.16295
CCL22 chemokine (C-C motif) ligand 22 2.1604
CST1 cystatin SN 2.14595
CLCNKA chloride channel, voltage-sensitive Ka 2.1227
CST4 cystatin S 2.1145
UNC50 unc-50 homolog (C. elegans) 2.1085
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.10507
TNIP1 TNFAIP3 interacting protein 1 2.08985
CLCNKB chloride channel, voltage-sensitive Kb 2.08525
METTL22 methyltransferase like 22 2.08365
TBP TATA box binding protein 2.0598
PRKN parkin RBR E3 ubiquitin protein ligase 2.05665
CST2 cystatin SA 2.05315
LMF1 lipase maturation factor 1 2.04575
TMEM165 transmembrane protein 165 2.0413
CABP1 calcium binding protein 1 2.02633
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.01725
SH3GL3 SH3-domain GRB2-like 3 2.0019

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.52085
OXA1L oxidase (cytochrome c) assembly 1-like -6.4909
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.40345
NGRN neugrin, neurite outgrowth associated -3.8251
RAI14 retinoic acid induced 14 -3.62835
DDIT4 DNA-damage-inducible transcript 4 -3.605
CDC25B cell division cycle 25B -3.5928
RFC2 replication factor C (activator 1) 2, 40kDa -3.56195
CCNB1 cyclin B1 -3.42565
HMG20B high mobility group 20B -3.2754
DCK deoxycytidine kinase -3.25055
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.97725
GDF15 growth differentiation factor 15 -2.8514
ZNF274 zinc finger protein 274 -2.5383
TOMM70 translocase of outer mitochondrial membrane 70 -2.5044
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.4705
RGS2 regulator of G-protein signaling 2 -2.4422
RNF167 ring finger protein 167 -2.44005
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.42967
HSPA8 heat shock 70kDa protein 8 -2.33727
RBM34 RNA binding motif protein 34 -2.17153
NVL nuclear VCP-like -2.17095
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.1397
SDCBP syndecan binding protein (syntenin) -2.1352
FXYD5 FXYD domain containing ion transport regulator 5 -2.1299
AHNAK2 AHNAK nucleoprotein 2 -2.11705
CERT1 ceramide transporter 1 -2.11085
LAMP5 lysosomal-associated membrane protein family, member 5 -2.0636
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.0453
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.0266
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.0153
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.00745