CRCGN008_HEPG2_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN008_HEPG2_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 10.0
PPARG peroxisome proliferator-activated receptor gamma 10.0
ADGRE5 adhesion G protein-coupled receptor E5 5.7433
EPHB2 EPH receptor B2 5.17165
CBR3 carbonyl reductase 3 4.9348
ATP11B ATPase, class VI, type 11B 4.89265
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.77235
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.6755
NOSIP nitric oxide synthase interacting protein 3.9929
LOC122526780 uncharacterized LOC122526780 3.87085
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.79374
EGF epidermal growth factor 3.62235
HYOU1 hypoxia up-regulated 1 3.2937
NUCB2 nucleobindin 2 2.8362
HLA-DRA major histocompatibility complex, class II, DR alpha 2.7845
ZNF589 zinc finger protein 589 2.7718
JADE2 jade family PHD finger 2 2.75635
CRTAP cartilage associated protein 2.7543
CHN1 chimerin 1 2.68645
NFE2L3 nuclear factor, erythroid 2-like 3 2.66765
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.6134
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.48496
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.4155
PMM2 phosphomannomutase 2 2.39255
PLSCR3 phospholipid scramblase 3 2.39183
PSIP1 PC4 and SFRS1 interacting protein 1 2.24785
SBNO1 strawberry notch homolog 1 (Drosophila) 2.2318
GPA33 glycoprotein A33 (transmembrane) 2.2048
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.14895
PRPF39 pre-mRNA processing factor 39 2.14815
SHCBP1 SHC SH2-domain binding protein 1 2.09535
SCRIB scribbled planar cell polarity protein 2.0926
ATAD2B ATPase family, AAA domain containing 2B 2.0912
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.0819
HELLS helicase, lymphoid-specific 2.07085
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.0463
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.03665
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.0182
HAUS6 HAUS augmin-like complex, subunit 6 2.00015

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.9039
CDC20 cell division cycle 20 -5.33725
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.0
DNM1L dynamin 1-like -4.67995
TLCD3A TLC domain containing 3A -4.576
TRIB3 tribbles pseudokinase 3 -4.43415
ZMIZ1 zinc finger, MIZ-type containing 1 -4.1056
RBM15B RNA binding motif protein 15B -4.032
GNAS GNAS complex locus -3.56791
PEG10 paternally expressed 10 -3.41663
CCNB2 cyclin B2 -3.25335
ELL2 elongation factor, RNA polymerase II, 2 -2.96375
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.80405
PGM1 phosphoglucomutase 1 -2.7717
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.72718
NRIP1 nuclear receptor interacting protein 1 -2.67337
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.61435
CTPS1 CTP synthase 1 -2.60275
HAMP hepcidin antimicrobial peptide -2.3262
ITPKC inositol-trisphosphate 3-kinase C -2.3148
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -2.2061
GSK3B glycogen synthase kinase 3 beta -2.16635
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.146
CST1 cystatin SN -2.1455
TRPS1 trichorhinophalangeal syndrome I -2.1206
RNF167 ring finger protein 167 -2.1161
TXNDC9 thioredoxin domain containing 9 -2.0912
HSPA8 heat shock 70kDa protein 8 -2.07543
GRIA3 glutamate receptor, ionotropic, AMPA 3 -2.05332
CLTB clathrin, light chain B -2.03671
CST2 cystatin SA -2.02005
CBX5 chromobox homolog 5 -2.01842
UNC13A unc-13 homolog A (C. elegans) -2.01755