CRCGN008_HEPG2_24H:P15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

177 genes differentially expressed following the CRCGN008_HEPG2_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 8.77715
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 6.2596
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.4709
ADRB2 adrenoceptor beta 2, surface 5.21265
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.00865
AMDHD2 amidohydrolase domain containing 2 4.70655
PPARG peroxisome proliferator-activated receptor gamma 4.7012
ABHD6 abhydrolase domain containing 6 4.65777
PRR15L proline rich 15-like 4.6514
CD40 CD40 molecule, TNF receptor superfamily member 5 4.42334
EGF epidermal growth factor 4.197
SFTPB surfactant protein B 3.70763
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.44905
CYCS cytochrome c, somatic 3.01925
JADE2 jade family PHD finger 2 3.01415
LPAR2 lysophosphatidic acid receptor 2 2.9267
ICAM1 intercellular adhesion molecule 1 2.89017
ARHGAP12 Rho GTPase activating protein 12 2.8155
MAP7 microtubule-associated protein 7 2.80872
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.74945
LOC122526780 uncharacterized LOC122526780 2.735
ZBTB32 zinc finger and BTB domain containing 32 2.7316
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.6672
ETNK1 ethanolamine kinase 1 2.64495
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.61995
APP amyloid beta (A4) precursor protein 2.61462
CNPY3 canopy FGF signaling regulator 3 2.5833
LTA lymphotoxin alpha 2.58025
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.5621
FGF3 fibroblast growth factor 3 2.538
TRAFD1 TRAF-type zinc finger domain containing 1 2.53753
MED13 mediator complex subunit 13 2.5167
QSER1 glutamine and serine rich 1 2.515
TNS4 tensin 4 2.4933
PNOC prepronociceptin 2.4812
CCL22 chemokine (C-C motif) ligand 22 2.4726
CCNDBP1 cyclin D-type binding-protein 1 2.47055
ZBTB5 zinc finger and BTB domain containing 5 2.46345
PXMP4 peroxisomal membrane protein 4, 24kDa 2.37815
CELA2B chymotrypsin-like elastase family, member 2B 2.3743
KITLG KIT ligand 2.37087
RAB30 RAB30, member RAS oncogene family 2.34965
KIAA0040 KIAA0040 2.33707
PCDHGA3 protocadherin gamma subfamily A, 3 2.3345
TNN tenascin N 2.31855
CCL17 chemokine (C-C motif) ligand 17 2.3077
PCDHGA10 protocadherin gamma subfamily A, 10 2.29585
PYDC1 PYD (pyrin domain) containing 1 2.29125
SLAMF1 signaling lymphocytic activation molecule family member 1 2.29085
CSRNP3 cysteine-serine-rich nuclear protein 3 2.2788
GSTM5 glutathione S-transferase mu 5 2.2702
FANCA Fanconi anemia, complementation group A 2.26793
ONECUT1 one cut homeobox 1 2.26115
MTNAP1 mitochondrial nucleoid associated protein 1 2.25925
NEUROD6 neuronal differentiation 6 2.25065
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.2499
PON3 paraoxonase 3 2.24755
TOX3 TOX high mobility group box family member 3 2.24685
GSTCD glutathione S-transferase, C-terminal domain containing 2.24055
PLA2G1B phospholipase A2, group IB (pancreas) 2.2327
POMT2 protein-O-mannosyltransferase 2 2.23225
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.2269
VEGFD vascular endothelial growth factor D 2.21455
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.2124
PAWR PRKC, apoptosis, WT1, regulator 2.21152
GPATCH8 G patch domain containing 8 2.21105
PPT2 palmitoyl-protein thioesterase 2 2.20845
CLOCK clock circadian regulator 2.20765
PROX1 prospero homeobox 1 2.20405
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.2027
ELAC2 elaC ribonuclease Z 2 2.20165
CSNK1G3 casein kinase 1, gamma 3 2.1968
TXNL4B thioredoxin-like 4B 2.1955
ASB4 ankyrin repeat and SOCS box containing 4 2.1913
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.1911
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.1871
LHX1 LIM homeobox 1 2.18685
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.18075
SPRED2 sprouty-related, EVH1 domain containing 2 2.17593
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.16485
TARBP2 TAR (HIV-1) RNA binding protein 2 2.1563
MICB MHC class I polypeptide-related sequence B 2.1554
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.1531
RNF43 ring finger protein 43 2.14545
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.14375
SIPA1 signal-induced proliferation-associated 1 2.13965
CCL8 chemokine (C-C motif) ligand 8 2.1374
DCC DCC netrin 1 receptor 2.102
PNMA3 paraneoplastic Ma antigen 3 2.09985
KRI1 KRI1 homolog (S. cerevisiae) 2.09905
NHLH1 nescient helix loop helix 1 2.0969
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.09425
NUP85 nucleoporin 85kDa 2.0874
CXXC4 CXXC finger protein 4 2.08645
S100A5 S100 calcium binding protein A5 2.0854
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa 2.0819
WNT3 wingless-type MMTV integration site family, member 3 2.0777
GLP2R glucagon-like peptide 2 receptor 2.0756
LARP4 La ribonucleoprotein domain family, member 4 2.0754
CHRD chordin 2.07288
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.07045
HPN hepsin 2.07025
GDAP1 ganglioside induced differentiation associated protein 1 2.06995
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.06815
NEUROD4 neuronal differentiation 4 2.0655
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.06255
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.0614
CD1E CD1e molecule 2.04917
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.04855
RFX7 regulatory factor X, 7 2.0453
ZMYM3 zinc finger, MYM-type 3 2.04305
LIME1 Lck interacting transmembrane adaptor 1 2.04025
SYNGR2 synaptogyrin 2 2.03995
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.0395
MFAP4 microfibrillar-associated protein 4 2.0389
HPSE2 heparanase 2 (inactive) 2.03575
LNPEP leucyl/cystinyl aminopeptidase 2.03085
AFTPH aftiphilin 2.02775
TLE6 transducin-like enhancer of split 6 2.021
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.0194
CCL11 chemokine (C-C motif) ligand 11 2.0189
NKX6-1 NK6 homeobox 1 2.01605
FAAP100 FA core complex associated protein 100 2.01125
OCLN occludin 2.0097
CDX4 caudal type homeobox 4 2.00735
BRD9 bromodomain containing 9 2.00265

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
LDHD lactate dehydrogenase D -10.0
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -10.0
CCNB2 cyclin B2 -8.2808
THAP11 THAP domain containing 11 -4.88865
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.7829
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7678
CCDC86 coiled-coil domain containing 86 -4.75305
HLA-DMA major histocompatibility complex, class II, DM alpha -4.71865
CDC20 cell division cycle 20 -4.66275
CDC25B cell division cycle 25B -4.4308
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.2633
SLC35F2 solute carrier family 35, member F2 -4.18435
ZNF274 zinc finger protein 274 -3.6872
ZMIZ1 zinc finger, MIZ-type containing 1 -3.6864
TES testin LIM domain protein -3.63685
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.632
HSPB1 heat shock 27kDa protein 1 -3.53015
VDAC1 voltage-dependent anion channel 1 -3.41015
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.26192
TM9SF3 transmembrane 9 superfamily member 3 -3.08745
SEC61G Sec61 gamma subunit -2.8654
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.81975
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.6371
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -2.5271
SNX6 sorting nexin 6 -2.52505
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.51515
OXA1L oxidase (cytochrome c) assembly 1-like -2.44895
HSPA8 heat shock 70kDa protein 8 -2.40998
LMO4 LIM domain only 4 -2.34775
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.34345
TWIST1 twist family bHLH transcription factor 1 -2.26595
LOC127933115 uncharacterized LOC127933115 -2.24775
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.226
DCK deoxycytidine kinase -2.2252
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.21985
ADISSP adipose secreted signaling protein -2.2054
COPG1 coatomer protein complex, subunit gamma 1 -2.1922
DDRGK1 DDRGK domain containing 1 -2.1917
RHOBTB1 Rho-related BTB domain containing 1 -2.13935
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.1375
PLS3 plastin 3 -2.11485
TMEM230 transmembrane protein 230 -2.1084
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.08505
NFU1 NFU1 iron-sulfur cluster scaffold -2.06885
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.02925
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.02355
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.0139
TASL TLR adaptor interacting with endolysosomal SLC15A4 -2.01075
AHNAK2 AHNAK nucleoprotein 2 -2.0057
TNS3 tensin 3 -2.001