CRCGN008_HEPG2_24H:P17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN008_HEPG2_24H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.74985
CCNF cyclin F 5.59475
MYLK myosin light chain kinase 5.5866
PPARG peroxisome proliferator-activated receptor gamma 5.3361
KIFBP kinesin family binding protein 5.12995
CBR3 carbonyl reductase 3 4.81885
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.7973
CHMP6 charged multivesicular body protein 6 4.42305
ALDOC aldolase C, fructose-bisphosphate 4.1414
LYN LYN proto-oncogene, Src family tyrosine kinase 3.83792
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.431
LPAR2 lysophosphatidic acid receptor 2 3.30433
CHN1 chimerin 1 3.15175
EGF epidermal growth factor 3.12175
TXNL4B thioredoxin-like 4B 3.0816
SSBP2 single-stranded DNA binding protein 2 2.77075
KIF20A kinesin family member 20A 2.67925
JADE2 jade family PHD finger 2 2.6566
TBPL1 TBP-like 1 2.56945
CNPY3 canopy FGF signaling regulator 3 2.29845
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2831
FOS FBJ murine osteosarcoma viral oncogene homolog 2.2678
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.259
HEBP1 heme binding protein 1 2.2266
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.21213
HSPA1A heat shock 70kDa protein 1A 2.08415
SCRN1 secernin 1 2.02655

decreased expression

Symbol Name Standardized Value
LOC124907782 dual specificity protein phosphatase 22 -7.29765
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.7102
CCNB2 cyclin B2 -4.8094
TLCD3A TLC domain containing 3A -4.80405
ADI1 acireductone dioxygenase 1 -4.70805
VAT1 vesicle amine transport 1 -4.4148
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -4.28145
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.12495
FBXL12 F-box and leucine-rich repeat protein 12 -3.3038
CLIC4 chloride intracellular channel 4 -3.28263
NGRN neugrin, neurite outgrowth associated -3.02215
FASTKD5 FAST kinase domains 5 -2.9109
MTA1 metastasis associated 1 -2.7822
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.7703
HSPA8 heat shock 70kDa protein 8 -2.59465
TCEAL4 transcription elongation factor A (SII)-like 4 -2.5771
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.4751
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.28525
WASHC4 WASH complex subunit 4 -2.2575
CDC25B cell division cycle 25B -2.18545
TOR1A torsin family 1, member A (torsin A) -2.06315
GET1 guided entry of tail-anchored proteins factor 1 -2.05105
ATXN3 ataxin 3 -2.03385