CRCGN008_HEPG2_24H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN008_HEPG2_24H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.01785
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.26245
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.7291
NOSIP nitric oxide synthase interacting protein 4.63015
CBR3 carbonyl reductase 3 4.50595
EGF epidermal growth factor 4.2255
ARL4C ADP-ribosylation factor-like 4C 3.6127
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.58305
CCL2 chemokine (C-C motif) ligand 2 3.34355
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.28358
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.9657
JADE2 jade family PHD finger 2 2.59882
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.55148
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.47445
ADAT1 adenosine deaminase, tRNA-specific 1 2.4083
ANO1 anoctamin 1, calcium activated chloride channel 2.3988
CCNC cyclin C 2.35525
NUP85 nucleoporin 85kDa 2.24535
TLR4 toll-like receptor 4 2.2193
CHSY1 chondroitin sulfate synthase 1 2.1811
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.14262
TRIM32 tripartite motif containing 32 2.13915
KLHL9 kelch-like family member 9 2.12297
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.1194
ARL5A ADP-ribosylation factor-like 5A 2.097
XPO1 exportin 1 2.0931
MSRB1 methionine sulfoxide reductase B1 2.0568
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.0492
OSBPL11 oxysterol binding protein-like 11 2.04825
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.025
SLC25A46 solute carrier family 25, member 46 2.01145

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.0218
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
CD320 CD320 molecule -5.2333
CDC20 cell division cycle 20 -4.6933
PCNA proliferating cell nuclear antigen -4.50795
CISD1 CDGSH iron sulfur domain 1 -3.9972
VDAC1 voltage-dependent anion channel 1 -3.6685
HSPA8 heat shock 70kDa protein 8 -3.06948
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.0125
OXA1L oxidase (cytochrome c) assembly 1-like -2.80405
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.7868
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.60105
TBX21 T-box 21 -2.5614
SPDEF SAM pointed domain containing ETS transcription factor -2.56007
GBX1 gastrulation brain homeobox 1 -2.5599
ADM2 adrenomedullin 2 -2.4683
ARHGAP22 Rho GTPase activating protein 22 -2.42015
CLTB clathrin, light chain B -2.41348
CPNE7 copine VII -2.3784
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.3746
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit -2.34765
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.3399
HSF4 heat shock transcription factor 4 -2.3382
FOS FBJ murine osteosarcoma viral oncogene homolog -2.325
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.256
DNASE1L2 deoxyribonuclease I-like 2 -2.23905
FAM53B family with sequence similarity 53, member B -2.2243
KIFAP3 kinesin-associated protein 3 -2.17265
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.15805
CA7 carbonic anhydrase VII -2.1551
SYNGR3 synaptogyrin 3 -2.14945
EVC Ellis van Creveld protein -2.1387
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.12835
SUSD6 sushi domain containing 6 -2.12465
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.11875
MEPE matrix extracellular phosphoglycoprotein -2.10685
CLDN11 claudin 11 -2.10655
FHL2 four and a half LIM domains 2 -2.1005
IL13 interleukin 13 -2.08615
NVL nuclear VCP-like -2.06645
LYZL6 lysozyme-like 6 -2.0528
TBXT T-box transcription factor T -2.04645
ZBTB7B zinc finger and BTB domain containing 7B -2.04045
CD48 CD48 molecule -2.036
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.01825
PCBP4 poly(rC) binding protein 4 -2.0166
TTLL1 tubulin tyrosine ligase-like family member 1 -2.0149
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.00475
MACROH2A2 macroH2A.2 histone -2.00005