CRCGN009_HEPG2_24H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN009_HEPG2_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.97973
MAP7 microtubule-associated protein 7 5.13838
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.63101
CIAO3 cytosolic iron-sulfur assembly component 3 4.2343
LPAR2 lysophosphatidic acid receptor 2 3.92341
MICALL1 MICAL-like 1 3.71385
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.44025
NFIL3 nuclear factor, interleukin 3 regulated 3.16327
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.09753
GATA3 GATA binding protein 3 2.99702
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.92422
GPATCH8 G patch domain containing 8 2.82976
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.75521
CD40 CD40 molecule, TNF receptor superfamily member 5 2.71144
LSR lipolysis stimulated lipoprotein receptor 2.59732
PLSCR1 phospholipid scramblase 1 2.59699
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.54285
KDM5A lysine (K)-specific demethylase 5A 2.45281
GPER1 G protein-coupled estrogen receptor 1 2.39038
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.33761
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.26867
JADE2 jade family PHD finger 2 2.24886
NT5DC2 5'-nucleotidase domain containing 2 2.15689
HLA-DMA major histocompatibility complex, class II, DM alpha 2.14879
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.13353
IL36G interleukin 36, gamma 2.09194
STAP2 signal transducing adaptor family member 2 2.03466
BLMH bleomycin hydrolase 2.00452

decreased expression

Symbol Name Standardized Value
FAIM Fas apoptotic inhibitory molecule -6.73503
LDHD lactate dehydrogenase D -6.6989
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.49286
GNAS GNAS complex locus -5.49596
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.40412
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.16064
PEG10 paternally expressed 10 -3.73392
PTPRK protein tyrosine phosphatase, receptor type, K -3.41303
YME1L1 YME1-like 1 ATPase -3.28777
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.26054
CCNB2 cyclin B2 -3.06459
ADI1 acireductone dioxygenase 1 -2.88519
TRIB3 tribbles pseudokinase 3 -2.7428
RFC2 replication factor C (activator 1) 2, 40kDa -2.56689
NVL nuclear VCP-like -2.54351
HMG20B high mobility group 20B -2.37067
PCNA proliferating cell nuclear antigen -2.33646
UBE3C ubiquitin protein ligase E3C -2.31314
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.28123
HDAC9 histone deacetylase 9 -2.13619
CCNH cyclin H -2.12891
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.08372
CRELD2 cysteine-rich with EGF-like domains 2 -2.06436