CRCGN009_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN009_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 4.23488
PNKP polynucleotide kinase 3'-phosphatase 3.93313
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.91334
BACE2 beta-site APP-cleaving enzyme 2 3.67302
RPL39L ribosomal protein L39-like 3.63469
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.61494
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.5696
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.44298
LPAR2 lysophosphatidic acid receptor 2 3.34038
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.26641
PPARG peroxisome proliferator-activated receptor gamma 3.09123
SQOR sulfide quinone oxidoreductase 3.08162
NOTCH1 notch 1 3.025
ZFP36 ZFP36 ring finger protein 2.85878
SFTPB surfactant protein B 2.81017
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.80124
SH3D19 SH3 domain containing 19 2.44203
PIH1D1 PIH1 domain containing 1 2.15247
PARP2 poly (ADP-ribose) polymerase 2 2.12787
OXCT1 3-oxoacid CoA transferase 1 2.11637
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.04419

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ZNF586 zinc finger protein 586 -7.10855
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.95155
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.02735
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.51495
TLCD3A TLC domain containing 3A -4.1337
PRPF4 pre-mRNA processing factor 4 -4.0798
UGDH UDP-glucose 6-dehydrogenase -3.85589
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.72239
DNM1L dynamin 1-like -3.72084
CSK c-src tyrosine kinase -3.66406
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.55868
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.11591
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.9551
TCTN1 tectonic family member 1 -2.79592
PCNA proliferating cell nuclear antigen -2.77551
MAPK13 mitogen-activated protein kinase 13 -2.70543
TLR4 toll-like receptor 4 -2.63724
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.45354
SNX11 sorting nexin 11 -2.4332
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.11479
SPRR2B small proline-rich protein 2B -2.11218
METTL18 methyltransferase like 18 -2.11001
LY6D lymphocyte antigen 6 complex, locus D -2.10955
ZNF750 zinc finger protein 750 -2.09889
LGALS7B lectin, galactoside-binding, soluble, 7B -2.05016
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.04258
CRELD2 cysteine-rich with EGF-like domains 2 -2.01645