CRCGN009_HEPG2_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

128 genes differentially expressed following the CRCGN009_HEPG2_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.5416
TXNRD1 thioredoxin reductase 1 6.14779
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.1342
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 6.01126
LCN2 lipocalin 2 5.92144
ABHD4 abhydrolase domain containing 4 5.91333
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.34689
UGDH UDP-glucose 6-dehydrogenase 5.30701
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.08804
PEX11A peroxisomal biogenesis factor 11 alpha 4.07288
LPAR2 lysophosphatidic acid receptor 2 4.00284
GPER1 G protein-coupled estrogen receptor 1 3.91274
KEAP1 kelch-like ECH-associated protein 1 3.79988
ALDOC aldolase C, fructose-bisphosphate 3.73669
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.69779
CHN1 chimerin 1 3.66788
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.60321
CDC45 cell division cycle 45 3.60057
SQSTM1 sequestosome 1 3.3929
ZFP36 ZFP36 ring finger protein 3.18546
E2F2 E2F transcription factor 2 3.1253
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.07695
CNPY3 canopy FGF signaling regulator 3 3.06453
NOSIP nitric oxide synthase interacting protein 3.04081
NANOS3 nanos homolog 3 (Drosophila) 2.99287
ADRB2 adrenoceptor beta 2, surface 2.93172
DUSP4 dual specificity phosphatase 4 2.91942
TRIM13 tripartite motif containing 13 2.8832
DDIT4 DNA-damage-inducible transcript 4 2.87764
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.8651
EPHB2 EPH receptor B2 2.83986
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.782
CCP110 centriolar coiled coil protein 110kDa 2.73049
FOXO4 forkhead box O4 2.71657
BACE2 beta-site APP-cleaving enzyme 2 2.69678
EVL Enah/Vasp-like 2.67952
HMOX1 heme oxygenase 1 2.62122
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.5757
CAPN1 calpain 1, (mu/I) large subunit 2.55148
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.5348
NUCB2 nucleobindin 2 2.52421
EPN2 epsin 2 2.48271
SKIC2 SKI2 subunit of superkiller complex 2.45747
MAMLD1 mastermind-like domain containing 1 2.44771
BMP4 bone morphogenetic protein 4 2.43127
MCM3 minichromosome maintenance complex component 3 2.4303
HLA-DRA major histocompatibility complex, class II, DR alpha 2.36897
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.31147
CCNF cyclin F 2.29993
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.27653
ALAS1 5'-aminolevulinate synthase 1 2.23823
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.23803
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.23174
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.20506
SNAP25 synaptosomal-associated protein, 25kDa 2.20288
CATSPER2 cation channel, sperm associated 2 2.18284
PGM1 phosphoglucomutase 1 2.09216
UBA7 ubiquitin-like modifier activating enzyme 7 2.0909
CYCS cytochrome c, somatic 2.07693
MED15 mediator complex subunit 15 2.06376
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.06268
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.05746
MAP7 microtubule-associated protein 7 2.05625
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.05017
ECI1 enoyl-CoA delta isomerase 1 2.0479
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.03672
GSR glutathione reductase 2.0095
ZNF692 zinc finger protein 692 2.00848
SARAF store-operated calcium entry-associated regulatory factor 2.00603
FZD7 frizzled class receptor 7 2.0034

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -6.69543
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.31514
SLC35F2 solute carrier family 35, member F2 -5.75364
TLR4 toll-like receptor 4 -5.16987
PSRC1 proline/serine-rich coiled-coil 1 -5.03942
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.6364
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.31971
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.26069
CCNB1 cyclin B1 -4.22729
TCTN1 tectonic family member 1 -4.21406
ADI1 acireductone dioxygenase 1 -4.2121
FGFR4 fibroblast growth factor receptor 4 -4.12074
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.11668
PLK1 polo-like kinase 1 -4.08663
CDC20 cell division cycle 20 -4.0703
NGRN neugrin, neurite outgrowth associated -3.77126
CCDC86 coiled-coil domain containing 86 -3.69416
CCNB2 cyclin B2 -3.49672
UBE2C ubiquitin-conjugating enzyme E2C -3.39534
RSU1 Ras suppressor protein 1 -3.25618
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.24521
TCEAL4 transcription elongation factor A (SII)-like 4 -3.22653
SPAG4 sperm associated antigen 4 -3.20889
IMPACT impact RWD domain protein -3.06391
ZNF586 zinc finger protein 586 -3.04403
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.94828
CLTB clathrin, light chain B -2.82962
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.76626
HAT1 histone acetyltransferase 1 -2.70807
RNF167 ring finger protein 167 -2.55516
SHB Src homology 2 domain containing adaptor protein B -2.55332
CDK1 cyclin-dependent kinase 1 -2.47873
RPS5 ribosomal protein S5 -2.47617
RPP38 ribonuclease P/MRP 38kDa subunit -2.41477
STAP2 signal transducing adaptor family member 2 -2.39957
NLRP2B NLR family pyrin domain containing 2B -2.35506
STMN1 stathmin 1 -2.32375
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.3117
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.30736
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.2623
SCAND1 SCAN domain containing 1 -2.25754
GTF2A2 general transcription factor IIA, 2, 12kDa -2.25198
UBE3C ubiquitin protein ligase E3C -2.24488
TMEM160 transmembrane protein 160 -2.24445
S100A3 S100 calcium binding protein A3 -2.23423
CCNA2 cyclin A2 -2.23299
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.16766
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.14972
TXNDC9 thioredoxin domain containing 9 -2.13783
TOP2A topoisomerase (DNA) II alpha 170kDa -2.13431
COPS7A COP9 signalosome subunit 7A -2.10591
CCDC85B coiled-coil domain containing 85B -2.07846
HTRA1 HtrA serine peptidase 1 -2.04807
TSSC4 tumor suppressing subtransferable candidate 4 -2.04517
HSPB1 heat shock 27kDa protein 1 -2.04234
HSPA1A heat shock 70kDa protein 1A -2.02513
LOC124907782 dual specificity protein phosphatase 22 -2.00844
ISOC1 isochorismatase domain containing 1 -2.00136