CRCGN009_HEPG2_24H:A12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN009_HEPG2_24H:A12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.2085
PEX11A peroxisomal biogenesis factor 11 alpha 5.048
PRR15L proline rich 15-like 4.79386
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.17647
CHN1 chimerin 1 4.16388
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.13651
CARMIL1 capping protein regulator and myosin 1 linker 1 4.1279
CYCS cytochrome c, somatic 3.94952
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.84815
KIFBP kinesin family binding protein 3.6604
STIMATE STIM activating enhancer 3.5255
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.52481
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.48894
MYLK myosin light chain kinase 3.47533
FCHO1 FCH domain only 1 3.24674
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.21651
INTS3 integrator complex subunit 3 3.14006
LPAR2 lysophosphatidic acid receptor 2 3.10429
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.02745
FZD7 frizzled class receptor 7 2.82201
CCDC85B coiled-coil domain containing 85B 2.80994
GSTZ1 glutathione S-transferase zeta 1 2.74943
CNPY3 canopy FGF signaling regulator 3 2.73872
TIAM1 T-cell lymphoma invasion and metastasis 1 2.72176
GHR growth hormone receptor 2.6928
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.68311
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.67724
GRWD1 glutamate-rich WD repeat containing 1 2.61685
KLHL21 kelch-like family member 21 2.58682
STK10 serine/threonine kinase 10 2.53139
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.43294
LOXL1 lysyl oxidase-like 1 2.30154
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.29373
TGFB3 transforming growth factor, beta 3 2.25483
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.25074
FUT2 fucosyltransferase 2 (secretor status included) 2.22548
ANKRD40 ankyrin repeat domain 40 2.12911
DUSP4 dual specificity phosphatase 4 2.11668
HDGFL3 HDGF like 3 2.10654
CHEK2 checkpoint kinase 2 2.10183
DIPK1A divergent protein kinase domain 1A 2.07184
TBP TATA box binding protein 2.00196

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.52014
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.38434
ADI1 acireductone dioxygenase 1 -6.1632
FAIM Fas apoptotic inhibitory molecule -3.71973
PECR peroxisomal trans-2-enoyl-CoA reductase -3.64735
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.5233
ZMIZ1 zinc finger, MIZ-type containing 1 -3.42881
NGRN neugrin, neurite outgrowth associated -3.35959
GNAS GNAS complex locus -3.24396
LAP3 leucine aminopeptidase 3 -3.03207
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.99866
TCEAL4 transcription elongation factor A (SII)-like 4 -2.89359
ZNF586 zinc finger protein 586 -2.84566
RAI14 retinoic acid induced 14 -2.79297
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.74357
FBXL12 F-box and leucine-rich repeat protein 12 -2.59992
LOC124907782 dual specificity protein phosphatase 22 -2.56716
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.52725
EGF epidermal growth factor -2.4596
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.35315
CAB39 calcium binding protein 39 -2.32635
KIF13A kinesin family member 13A -2.32423
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.28898
ZFP37 ZFP37 zinc finger protein -2.28765
MYCT1 myc target 1 -2.28087
SLC35F2 solute carrier family 35, member F2 -2.27838
GOLT1B golgi transport 1B -2.27568
ENTREP2 endosomal transmembrane epsin interactor 2 -2.27496
DYNLT3 dynein, light chain, Tctex-type 3 -2.26421
GRB10 growth factor receptor-bound protein 10 -2.2347
GIPC2 GIPC PDZ domain containing family, member 2 -2.21433
PLPPR1 phospholipid phosphatase related 1 -2.18128
ELAC1 elaC ribonuclease Z 1 -2.17613
ANKRD10 ankyrin repeat domain 10 -2.15898
SH3GL1 SH3-domain GRB2-like 1 -2.12478
LOC102724560 cystathionine beta-synthase -2.10489
SUSD5 sushi domain containing 5 -2.08574
GLRA1 glycine receptor, alpha 1 -2.0568
PIH1D1 PIH1 domain containing 1 -2.05374
TLCD3A TLC domain containing 3A -2.01865
ANO10 anoctamin 10 -2.01311
TOR1A torsin family 1, member A (torsin A) -2.00851
NOX4 NADPH oxidase 4 -2.00636
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.00421