| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | o-aminoazotoluene 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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267 genes differentially expressed following the CRCGN009_HEPG2_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD4 | abhydrolase domain containing 4 | 7.33556 |
| TXNRD1 | thioredoxin reductase 1 | 6.89606 |
| UBQLN2 | ubiquilin 2 | 6.82473 |
| RAP1GAP | RAP1 GTPase activating protein | 6.80301 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 6.60482 |
| NUCB2 | nucleobindin 2 | 6.51203 |
| CHMP6 | charged multivesicular body protein 6 | 6.31931 |
| VAT1 | vesicle amine transport 1 | 6.19525 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 6.12875 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 5.62657 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 5.60026 |
| MVP | major vault protein | 5.35194 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 5.24067 |
| SQSTM1 | sequestosome 1 | 5.14569 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 5.13278 |
| LSR | lipolysis stimulated lipoprotein receptor | 4.82802 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.62579 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 4.27887 |
| AXIN1 | axin 1 | 4.20737 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.19674 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 4.0663 |
| ZFP36 | ZFP36 ring finger protein | 3.9241 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.81251 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.72801 |
| ANKRD10 | ankyrin repeat domain 10 | 3.69125 |
| SKIC2 | SKI2 subunit of superkiller complex | 3.68754 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.6536 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.64844 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.62146 |
| NOTCH1 | notch 1 | 3.58547 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.54057 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 3.50858 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 3.47721 |
| PRKCD | protein kinase C, delta | 3.45325 |
| KEAP1 | kelch-like ECH-associated protein 1 | 3.44531 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 3.39602 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.33315 |
| CCDC86 | coiled-coil domain containing 86 | 3.31775 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 3.29189 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.27199 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.23728 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 3.20737 |
| NOSIP | nitric oxide synthase interacting protein | 3.20717 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.18634 |
| NANOS3 | nanos homolog 3 (Drosophila) | 3.1572 |
| STX4 | syntaxin 4 | 3.06383 |
| HMG20B | high mobility group 20B | 3.05634 |
| CHN1 | chimerin 1 | 3.04641 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.96942 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.89411 |
| YIPF3 | Yip1 domain family, member 3 | 2.80585 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.80452 |
| TRIB3 | tribbles pseudokinase 3 | 2.79876 |
| GTPBP2 | GTP binding protein 2 | 2.7256 |
| LCN2 | lipocalin 2 | 2.70783 |
| RUSF1 | RUS family member 1 | 2.68463 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.65617 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.63576 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 2.63241 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.57315 |
| MAP7 | microtubule-associated protein 7 | 2.56904 |
| SPATA20 | spermatogenesis associated 20 | 2.55472 |
| PYGL | phosphorylase, glycogen, liver | 2.53994 |
| UBE3C | ubiquitin protein ligase E3C | 2.53102 |
| KIFBP | kinesin family binding protein | 2.49888 |
| METTL25B | methyltransferase like 25B | 2.47337 |
| LOC122526780 | uncharacterized LOC122526780 | 2.47188 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.47086 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 2.45808 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.43739 |
| CCDC92 | coiled-coil domain containing 92 | 2.43085 |
| DHX16 | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 2.42765 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 2.40392 |
| CYTH1 | cytohesin 1 | 2.38948 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 2.38703 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 2.37804 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.37623 |
| TBP | TATA box binding protein | 2.36313 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.36176 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.35065 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.30487 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 2.30339 |
| FOXO4 | forkhead box O4 | 2.30306 |
| TRADD | TNFRSF1A-associated via death domain | 2.29617 |
| CDC45 | cell division cycle 45 | 2.28256 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.27331 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.23188 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.22836 |
| TMEM184B | transmembrane protein 184B | 2.22648 |
| PMM2 | phosphomannomutase 2 | 2.2125 |
| TRIM16 | tripartite motif containing 16 | 2.19703 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 2.19663 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 2.16873 |
| ZDHHC11B | zinc finger, DHHC-type containing 11B | 2.16262 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.15669 |
| SETD1A | SET domain containing 1A | 2.14682 |
| FAM50A | family with sequence similarity 50, member A | 2.14241 |
| ZNF451 | zinc finger protein 451 | 2.13297 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 2.12568 |
| FOXJ3 | forkhead box J3 | 2.12263 |
| NPIPB5 | nuclear pore complex interacting protein family, member B5 | 2.12145 |
| MED15 | mediator complex subunit 15 | 2.12133 |
| KLHL21 | kelch-like family member 21 | 2.12096 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.11754 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.1039 |
| PLK3 | polo-like kinase 3 | 2.10155 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.09988 |
| ERCC5 | excision repair cross-complementation group 5 | 2.08464 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 2.08376 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 2.07885 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 2.07647 |
| BLCAP | bladder cancer associated protein | 2.07422 |
| BYSL | bystin-like | 2.0603 |
| SBDS | Shwachman-Bodian-Diamond syndrome | 2.05862 |
| ZNF282 | zinc finger protein 282 | 2.05556 |
| ATF3 | activating transcription factor 3 | 2.05393 |
| NIT1 | nitrilase 1 | 2.05134 |
| ZNF74 | zinc finger protein 74 | 2.05124 |
| RBM15B | RNA binding motif protein 15B | 2.04774 |
| CBR1 | carbonyl reductase 1 | 2.04197 |
| MEST | mesoderm specific transcript | 2.04029 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.03661 |
| CEP57 | centrosomal protein 57kDa | 2.02606 |
| CDR2L | cerebellar degeneration-related protein 2-like | 2.02606 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 2.02172 |
| FBXW4 | F-box and WD repeat domain containing 4 | 2.00597 |
| ZNF768 | zinc finger protein 768 | 2.00008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC35F2 | solute carrier family 35, member F2 | -7.10478 |
| CCNB1 | cyclin B1 | -6.7635 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -6.70398 |
| CDC20 | cell division cycle 20 | -6.65097 |
| TCTN1 | tectonic family member 1 | -6.44779 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -6.22733 |
| PLK1 | polo-like kinase 1 | -6.18868 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -5.55975 |
| CDK1 | cyclin-dependent kinase 1 | -5.39433 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.34217 |
| TLR4 | toll-like receptor 4 | -5.28985 |
| CD320 | CD320 molecule | -5.1169 |
| ADI1 | acireductone dioxygenase 1 | -4.99191 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -4.97807 |
| RPIA | ribose 5-phosphate isomerase A | -4.95763 |
| CCNA2 | cyclin A2 | -4.90942 |
| AURKB | aurora kinase B | -4.89889 |
| ALDOC | aldolase C, fructose-bisphosphate | -4.78063 |
| HAT1 | histone acetyltransferase 1 | -4.67297 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -4.31029 |
| MELK | maternal embryonic leucine zipper kinase | -4.30278 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.30167 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -4.18839 |
| ZNF274 | zinc finger protein 274 | -4.0882 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.06912 |
| TLCD3A | TLC domain containing 3A | -4.03759 |
| HMGA2 | high mobility group AT-hook 2 | -4.01382 |
| PGAM4 | phosphoglycerate mutase family member 4 | -4.01109 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -3.94206 |
| SOAT2 | sterol O-acyltransferase 2 | -3.75417 |
| BIRC5 | baculoviral IAP repeat containing 5 | -3.7268 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.68326 |
| STMN1 | stathmin 1 | -3.5876 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.58564 |
| PCNA | proliferating cell nuclear antigen | -3.48337 |
| LDHD | lactate dehydrogenase D | -3.43525 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -3.42223 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.41283 |
| AURKA | aurora kinase A | -3.38772 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.37982 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.36856 |
| LAP3 | leucine aminopeptidase 3 | -3.24869 |
| LBR | lamin B receptor | -3.1892 |
| PEG10 | paternally expressed 10 | -3.17635 |
| CCNB2 | cyclin B2 | -3.15121 |
| EGF | epidermal growth factor | -3.08404 |
| ENOPH1 | enolase-phosphatase 1 | -3.06683 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.97031 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.90013 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -2.88085 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.87847 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.86596 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -2.85846 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -2.8535 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.83549 |
| ZNF586 | zinc finger protein 586 | -2.79098 |
| SMC4 | structural maintenance of chromosomes 4 | -2.72786 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -2.71601 |
| SPAG4 | sperm associated antigen 4 | -2.71531 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.71252 |
| DNM1L | dynamin 1-like | -2.70692 |
| CDCA3 | cell division cycle associated 3 | -2.68122 |
| COQ3 | coenzyme Q3 methyltransferase | -2.67748 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.66118 |
| TMEM97 | transmembrane protein 97 | -2.63947 |
| CHMP4B | charged multivesicular body protein 4B | -2.63918 |
| CHEK2 | checkpoint kinase 2 | -2.63867 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.59859 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.59476 |
| ICAM3 | intercellular adhesion molecule 3 | -2.57482 |
| GPC5 | glypican 5 | -2.53392 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -2.5265 |
| HDAC2 | histone deacetylase 2 | -2.50286 |
| CENPE | centromere protein E, 312kDa | -2.50045 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -2.49178 |
| NUP85 | nucleoporin 85kDa | -2.46681 |
| CENPA | centromere protein A | -2.46527 |
| KIF15 | kinesin family member 15 | -2.46363 |
| DBF4 | DBF4 zinc finger | -2.43894 |
| FASTKD5 | FAST kinase domains 5 | -2.40436 |
| DEPDC1 | DEP domain containing 1 | -2.40326 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -2.39531 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -2.39371 |
| GLDC | glycine dehydrogenase (decarboxylating) | -2.37843 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.36929 |
| FHL2 | four and a half LIM domains 2 | -2.36733 |
| NUP93 | nucleoporin 93kDa | -2.36531 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -2.34983 |
| ZW10 | zw10 kinetochore protein | -2.34981 |
| POU4F2 | POU class 4 homeobox 2 | -2.33426 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.32937 |
| USP39 | ubiquitin specific peptidase 39 | -2.31965 |
| KIF4A | kinesin family member 4A | -2.29761 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.2817 |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | -2.2798 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -2.25445 |
| FBXO5 | F-box protein 5 | -2.25017 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -2.24569 |
| ARHGAP19 | Rho GTPase activating protein 19 | -2.24123 |
| MRPL12 | mitochondrial ribosomal protein L12 | -2.24088 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -2.23401 |
| RYR3 | ryanodine receptor 3 | -2.21173 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.2051 |
| COL3A1 | collagen, type III, alpha 1 | -2.20438 |
| TCERG1 | transcription elongation regulator 1 | -2.20247 |
| IMPACT | impact RWD domain protein | -2.20237 |
| IER3 | immediate early response 3 | -2.20202 |
| MLF1 | myeloid leukemia factor 1 | -2.19975 |
| FPGT | fucose-1-phosphate guanylyltransferase | -2.1917 |
| BMX | BMX non-receptor tyrosine kinase | -2.18712 |
| ECHDC1 | ethylmalonyl-CoA decarboxylase 1 | -2.18232 |
| TRMT5 | tRNA methyltransferase 5 | -2.16929 |
| ISOC1 | isochorismatase domain containing 1 | -2.16806 |
| MYH10 | myosin, heavy chain 10, non-muscle | -2.16465 |
| PNRC2 | proline-rich nuclear receptor coactivator 2 | -2.15779 |
| TXNDC9 | thioredoxin domain containing 9 | -2.15573 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.15546 |
| PBK | PDZ binding kinase | -2.15315 |
| ERCC6L | excision repair cross-complementation group 6-like | -2.15025 |
| MTFR1 | mitochondrial fission regulator 1 | -2.14892 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.14866 |
| EFHD2 | EF-hand domain family, member D2 | -2.13108 |
| MYCBP | MYC binding protein | -2.12825 |
| S100A4 | S100 calcium binding protein A4 | -2.12535 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.10474 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -2.0994 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.09166 |
| CDK4 | cyclin-dependent kinase 4 | -2.09056 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.08433 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.07556 |
| CDCA8 | cell division cycle associated 8 | -2.07368 |
| TAF5 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | -2.05724 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.05548 |
| ENO1 | enolase 1, (alpha) | -2.04807 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.04279 |
| FLG | filaggrin | -2.02556 |
| COL1A2 | collagen, type I, alpha 2 | -2.02372 |
| NEK2 | NIMA-related kinase 2 | -2.02154 |
| OIP5 | Opa interacting protein 5 | -2.02095 |
| EMC9 | ER membrane protein complex subunit 9 | -2.01072 |
