CRCGN009_HEPG2_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

208 genes differentially expressed following the CRCGN009_HEPG2_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 9.26428
CDPF1 cysteine-rich, DPF motif domain containing 1 6.66122
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 6.46326
BLCAP bladder cancer associated protein 6.24618
RAP1GAP RAP1 GTPase activating protein 5.61534
CEMIP2 cell migration inducing hyaluronidase 2 5.49258
TXNRD1 thioredoxin reductase 1 5.30997
VAT1 vesicle amine transport 1 5.26845
GSTZ1 glutathione S-transferase zeta 1 5.20375
MAP7 microtubule-associated protein 7 5.20173
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.09873
INPP1 inositol polyphosphate-1-phosphatase 4.92836
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.77044
DDB2 damage-specific DNA binding protein 2, 48kDa 4.74054
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.7328
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.45839
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.40923
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.31745
GPER1 G protein-coupled estrogen receptor 1 4.30224
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.23538
LCN2 lipocalin 2 3.9427
UBE2A ubiquitin-conjugating enzyme E2A 3.7386
MICALL1 MICAL-like 1 3.72057
CCDC86 coiled-coil domain containing 86 3.6738
KEAP1 kelch-like ECH-associated protein 1 3.64557
KLHL21 kelch-like family member 21 3.63
ANKRD10 ankyrin repeat domain 10 3.60182
ZBTB35 zinc finger and BTB domain containing 35 3.60073
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.55826
PRKCD protein kinase C, delta 3.55212
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.54008
NOTCH1 notch 1 3.50523
SQSTM1 sequestosome 1 3.44038
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.40668
CCL2 chemokine (C-C motif) ligand 2 3.34737
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.30586
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.19463
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.15665
TERF2IP telomeric repeat binding factor 2, interacting protein 3.12291
MVP major vault protein 3.10215
TBPL1 TBP-like 1 3.09634
TEX10 testis expressed 10 3.09317
NOSIP nitric oxide synthase interacting protein 3.02202
CCP110 centriolar coiled coil protein 110kDa 3.01714
CCDC92 coiled-coil domain containing 92 2.95526
ZFP36 ZFP36 ring finger protein 2.89815
PLS1 plastin 1 2.87273
KIFBP kinesin family binding protein 2.86992
CHN1 chimerin 1 2.86234
BACE2 beta-site APP-cleaving enzyme 2 2.8409
MTERF3 mitochondrial transcription termination factor 3 2.81069
MINDY1 MINDY lysine 48 deubiquitinase 1 2.79131
DIPK1A divergent protein kinase domain 1A 2.76547
ELAC2 elaC ribonuclease Z 2 2.7648
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.76345
SKIC2 SKI2 subunit of superkiller complex 2.71823
GPC1 glypican 1 2.67876
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.64816
TIMP2 TIMP metallopeptidase inhibitor 2 2.63238
TWF2 twinfilin actin binding protein 2 2.62392
CBR3 carbonyl reductase 3 2.62228
PIH1D1 PIH1 domain containing 1 2.60511
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.59245
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.58849
LSR lipolysis stimulated lipoprotein receptor 2.57968
AARS1 alanyl-tRNA synthetase 1 2.5581
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.55291
CHMP6 charged multivesicular body protein 6 2.51729
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.5016
ADGRG1 adhesion G protein-coupled receptor G1 2.49093
ZMAT3 zinc finger, matrin-type 3 2.45448
ATG2A autophagy related 2A 2.44433
NISCH nischarin 2.4332
TOR1A torsin family 1, member A (torsin A) 2.43068
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.41856
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.41413
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.36212
PHGDH phosphoglycerate dehydrogenase 2.34993
DDIT4 DNA-damage-inducible transcript 4 2.34905
HOXA10 homeobox A10 2.34132
PINK1 PTEN induced putative kinase 1 2.33385
FBXW4 F-box and WD repeat domain containing 4 2.32881
FOSL1 FOS-like antigen 1 2.31785
TUBB6 tubulin, beta 6 class V 2.31391
CDC25B cell division cycle 25B 2.30673
BAX BCL2-associated X protein 2.30163
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.27054
ATG9A autophagy related 9A 2.24549
NT5C2 5'-nucleotidase, cytosolic II 2.24158
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.2382
TGFB3 transforming growth factor, beta 3 2.21085
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.20346
CYCS cytochrome c, somatic 2.20033
SLC75A1 solute carrier family 75 member 1 2.19159
ZDHHC11B zinc finger, DHHC-type containing 11B 2.17568
FDXR ferredoxin reductase 2.16511
BSDC1 BSD domain containing 1 2.15585
TRIB3 tribbles pseudokinase 3 2.15526
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15385
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.15328
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.15172
LRRC41 leucine rich repeat containing 41 2.129
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.12534
BYSL bystin-like 2.10253
MAPK13 mitogen-activated protein kinase 13 2.0865
GADD45A growth arrest and DNA-damage-inducible, alpha 2.07938
RAB3B RAB3B, member RAS oncogene family 2.07357
HMG20B high mobility group 20B 2.06657
ARID4B AT rich interactive domain 4B (RBP1-like) 2.04706
THSD1 thrombospondin, type I, domain containing 1 2.0241
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.02213

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -7.43973
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.07644
TCTN1 tectonic family member 1 -6.96517
CDC20 cell division cycle 20 -6.37954
PECR peroxisomal trans-2-enoyl-CoA reductase -5.98206
TLCD3A TLC domain containing 3A -5.61699
CCNB2 cyclin B2 -5.14848
AURKB aurora kinase B -5.14451
PSRC1 proline/serine-rich coiled-coil 1 -4.95614
ALDOC aldolase C, fructose-bisphosphate -4.74259
SOAT2 sterol O-acyltransferase 2 -4.69786
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.65982
SLC35F2 solute carrier family 35, member F2 -4.61578
ADI1 acireductone dioxygenase 1 -4.39089
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.28886
RPIA ribose 5-phosphate isomerase A -4.09146
CD320 CD320 molecule -4.03172
PLK1 polo-like kinase 1 -4.01825
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.98897
CDK1 cyclin-dependent kinase 1 -3.96645
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.9469
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.93441
DERA deoxyribose-phosphate aldolase (putative) -3.83622
PGAM4 phosphoglycerate mutase family member 4 -3.66239
MSRA methionine sulfoxide reductase A -3.63255
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.5309
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.4555
HAT1 histone acetyltransferase 1 -3.41557
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.35186
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.27229
LAP3 leucine aminopeptidase 3 -3.08863
ZNF274 zinc finger protein 274 -3.07136
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.06434
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.0403
NRIP1 nuclear receptor interacting protein 1 -3.02478
MYL9 myosin, light chain 9, regulatory -3.0159
ANO10 anoctamin 10 -2.99053
HMGA2 high mobility group AT-hook 2 -2.96349
OXA1L oxidase (cytochrome c) assembly 1-like -2.91551
LDHD lactate dehydrogenase D -2.86143
ISOC1 isochorismatase domain containing 1 -2.84611
GTF2A2 general transcription factor IIA, 2, 12kDa -2.84574
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.81178
FGFR4 fibroblast growth factor receptor 4 -2.80486
BZW2 basic leucine zipper and W2 domains 2 -2.71191
CRELD2 cysteine-rich with EGF-like domains 2 -2.70843
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.64234
ZNF528 zinc finger protein 528 -2.61047
DENND2D DENN/MADD domain containing 2D -2.59406
PROS1 protein S (alpha) -2.59051
LOC112694756 uncharaterized LOC112694756 -2.5845
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.53254
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.49129
CCNA2 cyclin A2 -2.48608
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.476
HEATR1 HEAT repeat containing 1 -2.44933
APOM apolipoprotein M -2.43319
TCERG1 transcription elongation regulator 1 -2.42651
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.41576
CSK c-src tyrosine kinase -2.37941
LBR lamin B receptor -2.37882
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.37374
CHEK2 checkpoint kinase 2 -2.36914
SDF2L1 stromal cell-derived factor 2-like 1 -2.34895
TCEAL4 transcription elongation factor A (SII)-like 4 -2.34585
AHSG alpha-2-HS-glycoprotein -2.33376
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.31922
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.31117
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.29268
FPGT fucose-1-phosphate guanylyltransferase -2.27832
EPCIP exosomal polycystin 1 interacting protein -2.26964
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.24794
GNAS GNAS complex locus -2.23527
MEFV Mediterranean fever -2.21802
STMN1 stathmin 1 -2.21532
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.21181
MRPL12 mitochondrial ribosomal protein L12 -2.1728
MRPL44 mitochondrial ribosomal protein L44 -2.15766
ASTE1 asteroid homolog 1 (Drosophila) -2.15236
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.14802
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.14548
TCTN2 tectonic family member 2 -2.14267
COPS7A COP9 signalosome subunit 7A -2.12158
MAK16 MAK16 homolog (S. cerevisiae) -2.09688
MFAP1 microfibrillar-associated protein 1 -2.09173
AMDHD2 amidohydrolase domain containing 2 -2.08698
ZNF835 zinc finger protein 835 -2.08446
USP6NL USP6 N-terminal like -2.08092
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.08007
TLR4 toll-like receptor 4 -2.07215
GPC5 glypican 5 -2.05481
MVD mevalonate (diphospho) decarboxylase -2.0462
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.02814
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.00969
PCCB propionyl CoA carboxylase, beta polypeptide -2.00667
NUP93 nucleoporin 93kDa -2.00493
MANF mesencephalic astrocyte-derived neurotrophic factor -2.00353