CRCGN009_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

316 genes differentially expressed following the CRCGN009_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
BLCAP bladder cancer associated protein 7.79219
ABHD4 abhydrolase domain containing 4 7.75561
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 7.70391
INPP1 inositol polyphosphate-1-phosphatase 7.11523
KIFBP kinesin family binding protein 6.67482
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.29915
MICALL1 MICAL-like 1 6.26317
TIMP2 TIMP metallopeptidase inhibitor 2 6.22315
DDB2 damage-specific DNA binding protein 2, 48kDa 6.10212
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.99253
CNPY3 canopy FGF signaling regulator 3 5.91896
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.83213
LRP10 low density lipoprotein receptor-related protein 10 5.35855
ADGRE5 adhesion G protein-coupled receptor E5 5.06651
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 4.78468
TXNRD1 thioredoxin reductase 1 4.7148
ASCC3 activating signal cointegrator 1 complex subunit 3 4.68754
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.5602
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.34144
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.31308
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.23112
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.20268
TERF2IP telomeric repeat binding factor 2, interacting protein 4.17264
RAP1GAP RAP1 GTPase activating protein 4.10515
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.05977
KEAP1 kelch-like ECH-associated protein 1 3.9862
GPC1 glypican 1 3.90432
DUSP14 dual specificity phosphatase 14 3.84012
MAP7D1 MAP7 domain containing 1 3.68101
CASC3 cancer susceptibility candidate 3 3.67744
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.6413
CCDC92 coiled-coil domain containing 92 3.62413
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.54263
TWF2 twinfilin actin binding protein 2 3.51646
ANKRD10 ankyrin repeat domain 10 3.49918
ATG9A autophagy related 9A 3.44681
PPARG peroxisome proliferator-activated receptor gamma 3.31121
GADD45A growth arrest and DNA-damage-inducible, alpha 3.30708
FOSL1 FOS-like antigen 1 3.28288
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.27413
TNIP1 TNFAIP3 interacting protein 1 3.26972
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.24699
SKIC2 SKI2 subunit of superkiller complex 3.21799
UBE2A ubiquitin-conjugating enzyme E2A 3.21515
TUBB6 tubulin, beta 6 class V 3.17408
PRKCD protein kinase C, delta 3.16491
TIGAR TP53 induced glycolysis regulatory phosphatase 3.16274
AARS1 alanyl-tRNA synthetase 1 3.15877
CTSL cathepsin L 3.1322
ADGRG1 adhesion G protein-coupled receptor G1 3.07769
ATP11B ATPase, class VI, type 11B 2.94903
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.94307
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.93915
RALGDS ral guanine nucleotide dissociation stimulator 2.93825
CCDC86 coiled-coil domain containing 86 2.91244
EPN2 epsin 2 2.90633
ATG2A autophagy related 2A 2.90047
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.85948
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.84915
KDM5A lysine (K)-specific demethylase 5A 2.81113
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.77616
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.75705
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.74501
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.74246
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.73169
SQSTM1 sequestosome 1 2.70462
CDC45 cell division cycle 45 2.64986
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.6479
MINDY1 MINDY lysine 48 deubiquitinase 1 2.62239
SYNGR3 synaptogyrin 3 2.61208
XPC xeroderma pigmentosum, complementation group C 2.594
CIAO3 cytosolic iron-sulfur assembly component 3 2.5884
SUN2 Sad1 and UNC84 domain containing 2 2.58426
DUSP6 dual specificity phosphatase 6 2.57487
CEMIP2 cell migration inducing hyaluronidase 2 2.57083
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.5534
BECN1 beclin 1, autophagy related 2.53609
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.50585
DDIT4 DNA-damage-inducible transcript 4 2.49626
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.48388
TOR1A torsin family 1, member A (torsin A) 2.48288
CYCS cytochrome c, somatic 2.47903
PLXNB2 plexin B2 2.47248
CORO1A coronin, actin binding protein, 1A 2.47015
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.46966
RBM15B RNA binding motif protein 15B 2.46583
LSR lipolysis stimulated lipoprotein receptor 2.43824
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.42739
PHGDH phosphoglycerate dehydrogenase 2.41514
YIPF3 Yip1 domain family, member 3 2.41407
GPATCH8 G patch domain containing 8 2.40816
MCOLN1 mucolipin 1 2.40568
NISCH nischarin 2.39569
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.39403
NPDC1 neural proliferation, differentiation and control, 1 2.37347
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.36934
MVP major vault protein 2.36604
DDR1 discoidin domain receptor tyrosine kinase 1 2.32711
AEN apoptosis enhancing nuclease 2.3046
CAMTA2 calmodulin binding transcription activator 2 2.30158
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.29763
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.28616
TPRA1 transmembrane protein, adipocyte asscociated 1 2.27194
KLHL21 kelch-like family member 21 2.24506
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.22989
UBE3C ubiquitin protein ligase E3C 2.22868
TBC1D10B TBC1 domain family, member 10B 2.21952
DNM2 dynamin 2 2.21907
HBEGF heparin-binding EGF-like growth factor 2.20005
IL4R interleukin 4 receptor 2.1948
GCLC glutamate-cysteine ligase, catalytic subunit 2.19187
DNM1L dynamin 1-like 2.1877
SAR1B secretion associated, Ras related GTPase 1B 2.16331
TRIP12 thyroid hormone receptor interactor 12 2.16112
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.15577
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.15435
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.14987
NBR1 neighbor of BRCA1 gene 1 2.14587
FDXR ferredoxin reductase 2.1409
STX1A syntaxin 1A (brain) 2.13846
SLC75A1 solute carrier family 75 member 1 2.1304
ATMIN ATM interactor 2.12125
TEX10 testis expressed 10 2.12022
ZMAT3 zinc finger, matrin-type 3 2.1144
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.09564
IGFBP3 insulin-like growth factor binding protein 3 2.09304
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.09242
BAX BCL2-associated X protein 2.09036
MOK MOK protein kinase 2.07627
SIN3B SIN3 transcription regulator family member B 2.07358
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.0627
TESK1 testis-specific kinase 1 2.06082
PROSER1 proline and serine rich 1 2.04473
BTG2 BTG family, member 2 2.0414
LIF leukemia inhibitory factor 2.0372
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.03405
IGHMBP2 immunoglobulin mu binding protein 2 2.02762
MCM3 minichromosome maintenance complex component 3 2.01319
PLK3 polo-like kinase 3 2.00728
UBAP1 ubiquitin associated protein 1 2.00587
ULK1 unc-51 like autophagy activating kinase 1 2.0008

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -8.20237
ISOC1 isochorismatase domain containing 1 -7.93295
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.73871
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -6.65753
TCTN1 tectonic family member 1 -6.55612
ZW10 zw10 kinetochore protein -6.49654
PEG10 paternally expressed 10 -6.49396
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.2753
PECR peroxisomal trans-2-enoyl-CoA reductase -6.07039
SOAT2 sterol O-acyltransferase 2 -5.32643
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.2484
ALDOC aldolase C, fructose-bisphosphate -5.21275
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.20793
GNAS GNAS complex locus -5.06118
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.84595
MSRA methionine sulfoxide reductase A -4.70321
PROS1 protein S (alpha) -4.64467
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.60929
LOC124907782 dual specificity protein phosphatase 22 -4.59246
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.33383
PSRC1 proline/serine-rich coiled-coil 1 -4.30726
HAT1 histone acetyltransferase 1 -4.21986
OXA1L oxidase (cytochrome c) assembly 1-like -4.19989
RSU1 Ras suppressor protein 1 -4.06847
SLC35F2 solute carrier family 35, member F2 -4.03261
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.02517
RPIA ribose 5-phosphate isomerase A -3.97018
HEATR1 HEAT repeat containing 1 -3.96419
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.92672
DERA deoxyribose-phosphate aldolase (putative) -3.88182
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.53043
PARP1 poly (ADP-ribose) polymerase 1 -3.51538
CRELD2 cysteine-rich with EGF-like domains 2 -3.50569
NRIP1 nuclear receptor interacting protein 1 -3.41125
ANO10 anoctamin 10 -3.36799
CDK1 cyclin-dependent kinase 1 -3.36764
MYLK myosin light chain kinase -3.28732
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -3.17799
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.1688
PCCB propionyl CoA carboxylase, beta polypeptide -3.16753
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.1635
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.16059
TMEM97 transmembrane protein 97 -3.11257
STMN1 stathmin 1 -3.10935
SCAND1 SCAN domain containing 1 -3.10747
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.08339
PRPF4 pre-mRNA processing factor 4 -3.01314
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.97034
PGM1 phosphoglucomutase 1 -2.96002
CHEK2 checkpoint kinase 2 -2.94709
PLK1 polo-like kinase 1 -2.90954
HMGA2 high mobility group AT-hook 2 -2.90619
CDC20 cell division cycle 20 -2.9018
MRPL12 mitochondrial ribosomal protein L12 -2.85417
ADI1 acireductone dioxygenase 1 -2.82369
BLMH bleomycin hydrolase -2.80419
CCNA2 cyclin A2 -2.79293
PGAM4 phosphoglycerate mutase family member 4 -2.77492
QPRT quinolinate phosphoribosyltransferase -2.77316
MSH6 mutS homolog 6 -2.74039
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.73876
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.72874
MVD mevalonate (diphospho) decarboxylase -2.70139
GTF2A2 general transcription factor IIA, 2, 12kDa -2.69421
MTFR1 mitochondrial fission regulator 1 -2.68221
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.66564
ICAM3 intercellular adhesion molecule 3 -2.65032
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.6141
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.55244
RAPSN receptor-associated protein of the synapse -2.51908
RHOBTB1 Rho-related BTB domain containing 1 -2.51902
TCEAL4 transcription elongation factor A (SII)-like 4 -2.5181
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.51219
PEG3 paternally expressed 3 -2.49802
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.48794
SNX3 sorting nexin 3 -2.45575
KRT35 keratin 35, type I -2.44503
PLS1 plastin 1 -2.43931
GPC3 glypican 3 -2.43518
FAM117A family with sequence similarity 117, member A -2.43374
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.42338
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.42157
FRMPD1 FERM and PDZ domain containing 1 -2.41105
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.40158
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.39512
MSMO1 methylsterol monooxygenase 1 -2.39503
MUC7 mucin 7, secreted -2.38803
TRAPPC3 trafficking protein particle complex 3 -2.38609
FIG4 FIG4 phosphoinositide 5-phosphatase -2.37536
LBR lamin B receptor -2.36912
A1CF APOBEC1 complementation factor -2.36688
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.36037
NUP133 nucleoporin 133kDa -2.35145
SRBD1 S1 RNA binding domain 1 -2.31312
UXT ubiquitously-expressed, prefoldin-like chaperone -2.31197
ATP5MG ATP synthase membrane subunit g -2.30838
MTNAP1 mitochondrial nucleoid associated protein 1 -2.30242
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.29909
AURKB aurora kinase B -2.29754
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.28414
USP6NL USP6 N-terminal like -2.27622
TLR4 toll-like receptor 4 -2.263
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) -2.24525
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.2367
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.23347
ECEL1 endothelin converting enzyme-like 1 -2.21076
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.20741
DENND2D DENN/MADD domain containing 2D -2.20516
ANXA6 annexin A6 -2.20426
DNAI7 dynein axonemal intermediate chain 7 -2.20048
ZNF780A zinc finger protein 780A -2.19566
OCA2 oculocutaneous albinism II -2.18503
SV2C synaptic vesicle glycoprotein 2C -2.17648
AMDHD2 amidohydrolase domain containing 2 -2.16541
PPP4C protein phosphatase 4, catalytic subunit -2.16143
MYOD1 myogenic differentiation 1 -2.15521
GSTK1 glutathione S-transferase kappa 1 -2.15439
LMBR1 limb development membrane protein 1 -2.15057
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.14733
ATP5F1C ATP synthase F1 subunit gamma -2.1418
HMGN2 high mobility group nucleosomal binding domain 2 -2.14141
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 -2.13251
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -2.13159
LIPC lipase, hepatic -2.13147
PRAMEF13 PRAME family member 13 -2.12978
SUSD4 sushi domain containing 4 -2.12329
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.12316
PHF24 PHD finger protein 24 -2.11937
RFC2 replication factor C (activator 1) 2, 40kDa -2.11924
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.11803
SNTG2 syntrophin, gamma 2 -2.11646
REEP1 receptor accessory protein 1 -2.11412
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) -2.11351
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.11105
CCDC15 coiled-coil domain containing 15 -2.11049
TRIB3 tribbles pseudokinase 3 -2.10952
OCEL1 occludin/ELL domain containing 1 -2.10631
ZNF274 zinc finger protein 274 -2.1061
SDF2L1 stromal cell-derived factor 2-like 1 -2.10273
ELP4 elongator acetyltransferase complex subunit 4 -2.10092
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.09345
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.09142
TAC1 tachykinin, precursor 1 -2.08162
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.08004
SYNJ2BP synaptojanin 2 binding protein -2.07523
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.06989
MYL9 myosin, light chain 9, regulatory -2.06959
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.06775
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.06243
PIGR polymeric immunoglobulin receptor -2.06148
SLC30A10 solute carrier family 30, member 10 -2.05928
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.05492
FHL2 four and a half LIM domains 2 -2.05404
AGGF1 angiogenic factor with G patch and FHA domains 1 -2.05261
VSNL1 visinin-like 1 -2.05097
NUBPL nucleotide binding protein-like -2.04737
TRIM36 tripartite motif containing 36 -2.04708
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.04421
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.04284
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.0381
PLAAT2 phospholipase A and acyltransferase 2 -2.03765
HSPA8 heat shock 70kDa protein 8 -2.03764
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.02947
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.02811
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.02701
RBP1 retinol binding protein 1, cellular -2.02381
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.01662
OSBPL10 oxysterol binding protein-like 10 -2.01369
PXMP2 peroxisomal membrane protein 2, 22kDa -2.01208
AMELX amelogenin, X-linked -2.01136
MBD5 methyl-CpG binding domain protein 5 -2.01033
JRKL JRK-like -2.00617
SYP synaptophysin -2.00533
MPZL2 myelin protein zero-like 2 -2.00011