CRCGN009_HEPG2_24H:A17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

304 genes differentially expressed following the CRCGN009_HEPG2_24H:A17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
BLCAP bladder cancer associated protein 8.10394
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 8.05338
INPP1 inositol polyphosphate-1-phosphatase 7.73158
ABHD4 abhydrolase domain containing 4 7.14447
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.82325
MICALL1 MICAL-like 1 6.70512
DDB2 damage-specific DNA binding protein 2, 48kDa 5.48502
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 5.30762
LRP10 low density lipoprotein receptor-related protein 10 4.9524
CNPY3 canopy FGF signaling regulator 3 4.66803
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.61242
GPC1 glypican 1 4.57949
TXNRD1 thioredoxin reductase 1 4.3222
HLA-DMA major histocompatibility complex, class II, DM alpha 4.27847
NOTCH1 notch 1 4.2447
ANKRD10 ankyrin repeat domain 10 4.22461
MOK MOK protein kinase 4.20568
TERF2IP telomeric repeat binding factor 2, interacting protein 4.04183
ADGRG1 adhesion G protein-coupled receptor G1 4.02505
DUSP14 dual specificity phosphatase 14 3.9954
TEX10 testis expressed 10 3.98317
TUBB6 tubulin, beta 6 class V 3.94131
JADE2 jade family PHD finger 2 3.89729
TIMP2 TIMP metallopeptidase inhibitor 2 3.8145
STK10 serine/threonine kinase 10 3.78793
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.7523
LSR lipolysis stimulated lipoprotein receptor 3.74763
CCDC92 coiled-coil domain containing 92 3.71495
ATP11B ATPase, class VI, type 11B 3.66918
E2F2 E2F transcription factor 2 3.63147
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.61654
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.4954
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.48749
CASC3 cancer susceptibility candidate 3 3.45774
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.37832
FOSL1 FOS-like antigen 1 3.36046
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.34538
KDM5A lysine (K)-specific demethylase 5A 3.2912
IL4R interleukin 4 receptor 3.25163
AXIN1 axin 1 3.24698
TNIP1 TNFAIP3 interacting protein 1 3.24322
SMAD3 SMAD family member 3 3.22505
PRCC papillary renal cell carcinoma (translocation-associated) 3.15061
XPC xeroderma pigmentosum, complementation group C 2.97999
RAP1GAP RAP1 GTPase activating protein 2.95477
FOXJ3 forkhead box J3 2.91249
PLK3 polo-like kinase 3 2.86233
DNM1L dynamin 1-like 2.85848
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.83946
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.83888
FDXR ferredoxin reductase 2.83715
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.81156
KEAP1 kelch-like ECH-associated protein 1 2.78971
TRIB3 tribbles pseudokinase 3 2.75378
ZNF282 zinc finger protein 282 2.73341
TPD52L2 tumor protein D52-like 2 2.73261
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.72262
NISCH nischarin 2.70807
TP53BP2 tumor protein p53 binding protein 2 2.69038
GADD45A growth arrest and DNA-damage-inducible, alpha 2.68618
CCDC86 coiled-coil domain containing 86 2.67651
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.6555
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.63334
VAT1 vesicle amine transport 1 2.61887
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.61872
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.61196
DUSP6 dual specificity phosphatase 6 2.57918
ZFP36 ZFP36 ring finger protein 2.57547
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.5593
PRKD2 protein kinase D2 2.55519
RSAD2 radical S-adenosyl methionine domain containing 2 2.54888
PLSCR1 phospholipid scramblase 1 2.54454
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.50015
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.49446
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.48891
IFI16 interferon, gamma-inducible protein 16 2.47853
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.47341
DDIT4 DNA-damage-inducible transcript 4 2.45495
KAT6A K(lysine) acetyltransferase 6A 2.4507
CTSL cathepsin L 2.44182
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.42259
IER3 immediate early response 3 2.41786
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.40893
ZMAT3 zinc finger, matrin-type 3 2.40796
TIGAR TP53 induced glycolysis regulatory phosphatase 2.39983
ADGRE5 adhesion G protein-coupled receptor E5 2.38111
CDIP1 cell death-inducing p53 target 1 2.36495
GSTZ1 glutathione S-transferase zeta 1 2.36346
ATG9A autophagy related 9A 2.35807
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.34911
PRKCD protein kinase C, delta 2.3397
AMZ2 archaelysin family metallopeptidase 2 2.30832
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.30627
DDR1 discoidin domain receptor tyrosine kinase 1 2.29127
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.28762
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.27228
GATA2 GATA binding protein 2 2.26512
RGS2 regulator of G-protein signaling 2 2.26252
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.26172
IFI44L interferon-induced protein 44-like 2.26158
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.21727
SEC24C SEC24 family member C 2.21054
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.19202
TOR1A torsin family 1, member A (torsin A) 2.19055
YIPF3 Yip1 domain family, member 3 2.18924
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.18907
UBE3C ubiquitin protein ligase E3C 2.1811
TRIM22 tripartite motif containing 22 2.17696
AARS1 alanyl-tRNA synthetase 1 2.15824
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.15207
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.14811
MAPK13 mitogen-activated protein kinase 13 2.14751
MAP7D1 MAP7 domain containing 1 2.14648
IRAK1 interleukin-1 receptor-associated kinase 1 2.13394
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.12334
EPHA2 EPH receptor A2 2.10875
TRIM8 tripartite motif containing 8 2.10169
ITPKC inositol-trisphosphate 3-kinase C 2.10074
ELAC2 elaC ribonuclease Z 2 2.10069
MX1 MX dynamin-like GTPase 1 2.09306
FRS2 fibroblast growth factor receptor substrate 2 2.0796
IQGAP1 IQ motif containing GTPase activating protein 1 2.07892
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.06882
MMP1 matrix metallopeptidase 1 2.06504
THSD1 thrombospondin, type I, domain containing 1 2.06478
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.06161
CSNK1E casein kinase 1, epsilon 2.06146
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.0578
SLC35F5 solute carrier family 35, member F5 2.04611
STX3 syntaxin 3 2.0412
FOXK2 forkhead box K2 2.02999
ARID4B AT rich interactive domain 4B (RBP1-like) 2.0213
ICAM1 intercellular adhesion molecule 1 2.01518
MINDY1 MINDY lysine 48 deubiquitinase 1 2.01149
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.00959
OASL 2'-5'-oligoadenylate synthetase-like 2.0093
GPR87 G protein-coupled receptor 87 2.00926
CHD8 chromodomain helicase DNA binding protein 8 2.00488

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.74913
HACD3 3-hydroxyacyl-CoA dehydratase 3 -7.50177
LDHD lactate dehydrogenase D -6.83202
ZNF586 zinc finger protein 586 -6.58964
HAT1 histone acetyltransferase 1 -6.37316
ISOC1 isochorismatase domain containing 1 -6.36237
TCTN1 tectonic family member 1 -6.31479
RPIA ribose 5-phosphate isomerase A -6.13008
ALDOC aldolase C, fructose-bisphosphate -6.08729
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.05669
PECR peroxisomal trans-2-enoyl-CoA reductase -6.01812
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.83274
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.79197
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.77671
PCCB propionyl CoA carboxylase, beta polypeptide -5.6742
ZW10 zw10 kinetochore protein -5.64502
PROS1 protein S (alpha) -5.55968
SOAT2 sterol O-acyltransferase 2 -5.42606
CCNB2 cyclin B2 -5.27174
FGFR4 fibroblast growth factor receptor 4 -4.95865
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.85561
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.85011
RSU1 Ras suppressor protein 1 -4.70677
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.5282
ANO10 anoctamin 10 -4.52321
MNAT1 MNAT CDK-activating kinase assembly factor 1 -4.39193
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.37321
PSRC1 proline/serine-rich coiled-coil 1 -4.27959
ACAA1 acetyl-CoA acyltransferase 1 -4.20869
ADI1 acireductone dioxygenase 1 -4.00535
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.94843
NUCB2 nucleobindin 2 -3.8546
MSRA methionine sulfoxide reductase A -3.76355
MYLK myosin light chain kinase -3.71921
MYL9 myosin, light chain 9, regulatory -3.70636
ANXA7 annexin A7 -3.64564
STMN1 stathmin 1 -3.63355
LBR lamin B receptor -3.61801
CDC20 cell division cycle 20 -3.60373
CRELD2 cysteine-rich with EGF-like domains 2 -3.58294
PARP1 poly (ADP-ribose) polymerase 1 -3.50778
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.48272
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.46091
PLK1 polo-like kinase 1 -3.45725
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.44382
DERA deoxyribose-phosphate aldolase (putative) -3.41473
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.38068
BLMH bleomycin hydrolase -3.3402
HMGA2 high mobility group AT-hook 2 -3.28632
CDK1 cyclin-dependent kinase 1 -3.26601
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.24584
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.23235
PGAM4 phosphoglycerate mutase family member 4 -3.22219
ANAPC15 anaphase promoting complex subunit 15 -3.10295
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -3.09077
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.07949
LOC112694756 uncharaterized LOC112694756 -2.98822
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.9866
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.98245
PGM1 phosphoglucomutase 1 -2.94585
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.94038
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.91789
DENND2D DENN/MADD domain containing 2D -2.90581
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.8701
MSMO1 methylsterol monooxygenase 1 -2.86845
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.84761
ECH1 enoyl CoA hydratase 1, peroxisomal -2.81545
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.78626
C2CD5 C2 calcium-dependent domain containing 5 -2.69164
TCEAL4 transcription elongation factor A (SII)-like 4 -2.6882
ELP4 elongator acetyltransferase complex subunit 4 -2.68588
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.65878
TTC27 tetratricopeptide repeat domain 27 -2.65496
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.65272
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.64001
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.62601
AURKB aurora kinase B -2.60629
SNRPF small nuclear ribonucleoprotein polypeptide F -2.60324
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.59914
SPC25 SPC25, NDC80 kinetochore complex component -2.59488
CETN3 centrin, EF-hand protein, 3 -2.56442
SORD sorbitol dehydrogenase -2.55409
CCNA2 cyclin A2 -2.52931
SEC61G Sec61 gamma subunit -2.52818
NUP93 nucleoporin 93kDa -2.52799
TM9SF2 transmembrane 9 superfamily member 2 -2.49982
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.49704
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.49449
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.45525
ZNF552 zinc finger protein 552 -2.4548
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.43841
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.41302
CHMP6 charged multivesicular body protein 6 -2.41024
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.364
HADH hydroxyacyl-CoA dehydrogenase -2.36191
MCTS1 malignant T cell amplified sequence 1 -2.35385
CRYZ crystallin, zeta (quinone reductase) -2.34732
SDF2L1 stromal cell-derived factor 2-like 1 -2.33427
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.32255
SKIC8 SKI8 subunit of superkiller complex -2.31967
AURKA aurora kinase A -2.30844
PLS1 plastin 1 -2.29961
GTPBP3 GTP binding protein 3 (mitochondrial) -2.29707
LIME1 Lck interacting transmembrane adaptor 1 -2.294
HMOX1 heme oxygenase 1 -2.28917
PYCR1 pyrroline-5-carboxylate reductase 1 -2.27942
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27256
COQ3 coenzyme Q3 methyltransferase -2.26539
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.26033
HPX hemopexin -2.25619
HDAC2 histone deacetylase 2 -2.24986
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.24648
PLG plasminogen -2.23585
MRPL12 mitochondrial ribosomal protein L12 -2.23517
FIG4 FIG4 phosphoinositide 5-phosphatase -2.22104
SNX11 sorting nexin 11 -2.21868
NLRP2B NLR family pyrin domain containing 2B -2.2176
PHKB phosphorylase kinase, beta -2.21611
THAP11 THAP domain containing 11 -2.20752
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.203
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.20066
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.19639
TMEM97 transmembrane protein 97 -2.19467
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.19059
MARCKSL1 MARCKS-like 1 -2.18209
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.17728
UGDH UDP-glucose 6-dehydrogenase -2.17182
ATL2 atlastin GTPase 2 -2.17179
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.17019
SPAG5 sperm associated antigen 5 -2.16692
RABL3 RAB, member of RAS oncogene family-like 3 -2.16593
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.15795
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.15719
MSH6 mutS homolog 6 -2.1567
TEDC2 tubulin epsilon and delta complex 2 -2.14511
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.14384
BIRC5 baculoviral IAP repeat containing 5 -2.13832
LIN7C lin-7 homolog C (C. elegans) -2.13241
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.12902
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.12614
APIP APAF1 interacting protein -2.12476
GGCT gamma-glutamylcyclotransferase -2.1195
CBR1 carbonyl reductase 1 -2.11614
MRPS22 mitochondrial ribosomal protein S22 -2.1092
RPA3 replication protein A3, 14kDa -2.10877
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.09781
NUP37 nucleoporin 37kDa -2.09381
HSPE1 heat shock 10kDa protein 1 -2.09276
TRAPPC3 trafficking protein particle complex 3 -2.09247
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.08812
FASTKD3 FAST kinase domains 3 -2.08772
HEATR1 HEAT repeat containing 1 -2.08684
PEG10 paternally expressed 10 -2.08622
HEBP1 heme binding protein 1 -2.07856
MRPL48 mitochondrial ribosomal protein L48 -2.07057
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.05776
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.05328
VSNL1 visinin-like 1 -2.04678
SLC66A2 solute carrier family 66 member 2 -2.02384
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.02324
TXNL1 thioredoxin-like 1 -2.01098
MVD mevalonate (diphospho) decarboxylase -2.00608
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.00581
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.00446
PDZD2 PDZ domain containing 2 -2.00004