CRCGN009_HEPG2_24H:A18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

310 genes differentially expressed following the CRCGN009_HEPG2_24H:A18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BLCAP bladder cancer associated protein 8.54692
ABHD4 abhydrolase domain containing 4 8.1541
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 8.13323
INPP1 inositol polyphosphate-1-phosphatase 8.08748
MICALL1 MICAL-like 1 7.33823
ASCC3 activating signal cointegrator 1 complex subunit 3 6.73058
DDB2 damage-specific DNA binding protein 2, 48kDa 6.64281
CDPF1 cysteine-rich, DPF motif domain containing 1 6.09082
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.84661
TIMP2 TIMP metallopeptidase inhibitor 2 5.17213
CNPY3 canopy FGF signaling regulator 3 4.94652
CYCS cytochrome c, somatic 4.78995
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.50634
GPC1 glypican 1 4.41469
TERF2IP telomeric repeat binding factor 2, interacting protein 4.3262
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 4.26818
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.21276
FOSL1 FOS-like antigen 1 4.14616
TUBB6 tubulin, beta 6 class V 4.0244
KDM5A lysine (K)-specific demethylase 5A 4.00174
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.97028
TXNRD1 thioredoxin reductase 1 3.84346
ANKRD10 ankyrin repeat domain 10 3.80396
CCDC92 coiled-coil domain containing 92 3.71248
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.71018
TEX10 testis expressed 10 3.53671
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.52235
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.52098
KEAP1 kelch-like ECH-associated protein 1 3.50964
VAT1 vesicle amine transport 1 3.50818
EVL Enah/Vasp-like 3.42501
CASC3 cancer susceptibility candidate 3 3.40781
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 3.31037
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.28959
CCP110 centriolar coiled coil protein 110kDa 3.25567
KLHL21 kelch-like family member 21 3.22886
UBQLN2 ubiquilin 2 3.20334
ADGRG1 adhesion G protein-coupled receptor G1 3.17305
LRP10 low density lipoprotein receptor-related protein 10 3.14973
DYNLT3 dynein, light chain, Tctex-type 3 3.13459
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.13155
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.1016
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.07223
XPC xeroderma pigmentosum, complementation group C 3.03926
ATG9A autophagy related 9A 2.89096
ELAC2 elaC ribonuclease Z 2 2.88969
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.88161
UBE3C ubiquitin protein ligase E3C 2.88048
TWF2 twinfilin actin binding protein 2 2.85395
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.8262
DDIT4 DNA-damage-inducible transcript 4 2.7834
STX1A syntaxin 1A (brain) 2.77215
LSR lipolysis stimulated lipoprotein receptor 2.76548
CXCL2 chemokine (C-X-C motif) ligand 2 2.76366
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.75314
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.72481
PRKCD protein kinase C, delta 2.70564
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.70425
SKIC2 SKI2 subunit of superkiller complex 2.68256
IDE insulin-degrading enzyme 2.66859
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.65828
KIFBP kinesin family binding protein 2.65772
IL4R interleukin 4 receptor 2.64747
GATA2 GATA binding protein 2 2.62831
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.59487
ZBTB35 zinc finger and BTB domain containing 35 2.58902
AARS1 alanyl-tRNA synthetase 1 2.58785
RAP1GAP RAP1 GTPase activating protein 2.55184
DUSP6 dual specificity phosphatase 6 2.53676
CDC45 cell division cycle 45 2.52376
IER3 immediate early response 3 2.51259
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.50476
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.50406
MAP7D1 MAP7 domain containing 1 2.49089
TOR1A torsin family 1, member A (torsin A) 2.47513
UBE2A ubiquitin-conjugating enzyme E2A 2.46897
SFTPB surfactant protein B 2.46655
PIAS3 protein inhibitor of activated STAT, 3 2.42099
LAMB3 laminin, beta 3 2.40821
SMAD3 SMAD family member 3 2.39066
PROSER1 proline and serine rich 1 2.37888
PDCD11 programmed cell death 11 2.37866
CSNK1E casein kinase 1, epsilon 2.37412
BECN1 beclin 1, autophagy related 2.33586
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.33018
IRAK1 interleukin-1 receptor-associated kinase 1 2.32178
OFD1 oral-facial-digital syndrome 1 2.29515
POM121C POM121 transmembrane nucleoporin C 2.29457
NCOA6 nuclear receptor coactivator 6 2.27675
ZC3H4 zinc finger CCCH-type containing 4 2.27182
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.2606
ATG2A autophagy related 2A 2.2598
GARS1 glycyl-tRNA synthetase 1 2.25333
KDM3A lysine (K)-specific demethylase 3A 2.24566
ADGRE5 adhesion G protein-coupled receptor E5 2.23849
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.23571
ITCH itchy E3 ubiquitin protein ligase 2.22704
COG7 component of oligomeric golgi complex 7 2.21558
TIGAR TP53 induced glycolysis regulatory phosphatase 2.20298
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.19685
GADD45A growth arrest and DNA-damage-inducible, alpha 2.19637
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.18987
RBM15B RNA binding motif protein 15B 2.18114
HMBOX1 homeobox containing 1 2.18089
NPIPB5 nuclear pore complex interacting protein family, member B5 2.16757
PRAF2 PRA1 domain family, member 2 2.15274
ZMAT3 zinc finger, matrin-type 3 2.14392
RALGDS ral guanine nucleotide dissociation stimulator 2.13024
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.12092
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.11826
ULK1 unc-51 like autophagy activating kinase 1 2.1177
CHD8 chromodomain helicase DNA binding protein 8 2.09045
YY1AP1 YY1 associated protein 1 2.04208
SQSTM1 sequestosome 1 2.04177
EGR1 early growth response 1 2.03578
RBM10 RNA binding motif protein 10 2.0287
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.02543
MSN moesin 2.02295
DUSP14 dual specificity phosphatase 14 2.01833
S100A11 S100 calcium binding protein A11 2.01661
TP53 tumor protein p53 2.00729
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.00188

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -7.87499
FGFR4 fibroblast growth factor receptor 4 -7.87465
TCTN1 tectonic family member 1 -7.47252
LDHD lactate dehydrogenase D -6.65426
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -6.33253
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.12075
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.98953
PECR peroxisomal trans-2-enoyl-CoA reductase -5.92377
PCNA proliferating cell nuclear antigen -5.89699
ADI1 acireductone dioxygenase 1 -5.33797
RSU1 Ras suppressor protein 1 -5.29891
SOAT2 sterol O-acyltransferase 2 -4.87512
ALDOC aldolase C, fructose-bisphosphate -4.71819
ANO10 anoctamin 10 -4.70115
NUCB2 nucleobindin 2 -4.63024
PSRC1 proline/serine-rich coiled-coil 1 -4.6045
CRELD2 cysteine-rich with EGF-like domains 2 -4.27467
MSRA methionine sulfoxide reductase A -4.19682
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.19329
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.10007
MYL9 myosin, light chain 9, regulatory -4.04117
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.02005
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.93009
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.89001
DERA deoxyribose-phosphate aldolase (putative) -3.52797
CCNB1 cyclin B1 -3.46295
PEG10 paternally expressed 10 -3.44778
CCNB2 cyclin B2 -3.39339
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.36526
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.29775
COMMD10 COMM domain containing 10 -3.28427
RPIA ribose 5-phosphate isomerase A -3.27938
LOC124907782 dual specificity protein phosphatase 22 -3.23688
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -3.17464
BLMH bleomycin hydrolase -3.13186
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.09724
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -3.08195
PCCB propionyl CoA carboxylase, beta polypeptide -3.03244
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -3.00577
AURKB aurora kinase B -2.98867
TLR4 toll-like receptor 4 -2.98805
HAT1 histone acetyltransferase 1 -2.98524
ACAA1 acetyl-CoA acyltransferase 1 -2.97671
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.96375
ANXA7 annexin A7 -2.96192
PGM1 phosphoglucomutase 1 -2.96001
STMN1 stathmin 1 -2.93489
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.88849
ZNF586 zinc finger protein 586 -2.82628
HYOU1 hypoxia up-regulated 1 -2.78847
RFC2 replication factor C (activator 1) 2, 40kDa -2.70703
HMGA2 high mobility group AT-hook 2 -2.68535
A1CF APOBEC1 complementation factor -2.65567
PLS1 plastin 1 -2.63156
HADH hydroxyacyl-CoA dehydrogenase -2.62156
CBR1 carbonyl reductase 1 -2.59459
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.58479
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.52258
RABL3 RAB, member of RAS oncogene family-like 3 -2.51391
STAP2 signal transducing adaptor family member 2 -2.51053
FABP1 fatty acid binding protein 1, liver -2.50536
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.49942
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.49759
DENND2D DENN/MADD domain containing 2D -2.47819
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.47049
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.46859
MOCS2 molybdenum cofactor synthesis 2 -2.45593
PARP1 poly (ADP-ribose) polymerase 1 -2.45319
GPC5 glypican 5 -2.45099
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.45029
MSH6 mutS homolog 6 -2.44728
PKLR pyruvate kinase, liver and RBC -2.44274
TUBAL3 tubulin, alpha-like 3 -2.43694
CHMP6 charged multivesicular body protein 6 -2.43334
GIPC2 GIPC PDZ domain containing family, member 2 -2.42479
LBR lamin B receptor -2.41231
CCNA2 cyclin A2 -2.40215
NLRP2B NLR family pyrin domain containing 2B -2.38787
MSMO1 methylsterol monooxygenase 1 -2.38529
EPHA5 EPH receptor A5 -2.37984
HEBP1 heme binding protein 1 -2.37938
PID1 phosphotyrosine interaction domain containing 1 -2.37773
ADH6 alcohol dehydrogenase 6 (class V) -2.3748
CZIB CXXC motif containing zinc binding protein -2.36953
RAI14 retinoic acid induced 14 -2.36053
PLK1 polo-like kinase 1 -2.35251
PROS1 protein S (alpha) -2.34896
SELENOF selenoprotein F -2.34084
MVD mevalonate (diphospho) decarboxylase -2.33967
PAH phenylalanine hydroxylase -2.33864
TCEAL4 transcription elongation factor A (SII)-like 4 -2.32898
KRT35 keratin 35, type I -2.32027
GNAS GNAS complex locus -2.31985
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.30816
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.30175
LRRC19 leucine rich repeat containing 19 -2.29362
TRIM36 tripartite motif containing 36 -2.2924
CTNND2 catenin (cadherin-associated protein), delta 2 -2.29216
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.28924
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.28797
GLYAT glycine-N-acyltransferase -2.28208
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.27895
PDHX pyruvate dehydrogenase complex, component X -2.27797
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.27788
CPNE3 copine III -2.27715
TRAPPC3 trafficking protein particle complex 3 -2.26392
ILK integrin-linked kinase -2.25923
TPH1 tryptophan hydroxylase 1 -2.252
PHKB phosphorylase kinase, beta -2.24847
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.24782
ZIC4 Zic family member 4 -2.24583
SLC30A10 solute carrier family 30, member 10 -2.24243
GAP43 growth associated protein 43 -2.23199
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.23173
RIT2 Ras-like without CAAX 2 -2.22568
SDF2L1 stromal cell-derived factor 2-like 1 -2.22201
SYN2 synapsin II -2.21979
SLC17A2 solute carrier family 17, member 2 -2.21872
SKIC8 SKI8 subunit of superkiller complex -2.21437
TTC1 tetratricopeptide repeat domain 1 -2.21234
GPR50 G protein-coupled receptor 50 -2.20907
LYRM4 LYR motif containing 4 -2.2032
BTBD8 BTB (POZ) domain containing 8 -2.20238
ZNF385D zinc finger protein 385D -2.19923
SSTR2 somatostatin receptor 2 -2.195
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.18967
PXMP2 peroxisomal membrane protein 2, 22kDa -2.18452
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.17248
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -2.16277
CA7 carbonic anhydrase VII -2.15632
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.15459
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.15096
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.13913
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.13681
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.13378
CLIC5 chloride intracellular channel 5 -2.13253
KLK15 kallikrein-related peptidase 15 -2.12582
IFNA7 interferon, alpha 7 -2.123
EPCIP exosomal polycystin 1 interacting protein -2.12213
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.11676
ANAPC15 anaphase promoting complex subunit 15 -2.11095
ANGPTL7 angiopoietin-like 7 -2.10862
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.10338
RGN regucalcin -2.1029
ACSBG1 acyl-CoA synthetase bubblegum family member 1 -2.10013
CDO1 cysteine dioxygenase type 1 -2.09584
ATRNL1 attractin-like 1 -2.0949
THEM6 thioesterase superfamily member 6 -2.0884
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 -2.0873
LIME1 Lck interacting transmembrane adaptor 1 -2.08204
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -2.0813
IL17F interleukin 17F -2.08013
PCDHB8 protocadherin beta 8 -2.07867
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.0783
PGAM4 phosphoglycerate mutase family member 4 -2.07783
MBL2 mannose-binding lectin (protein C) 2, soluble -2.07361
TBX10 T-box 10 -2.07288
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.07224
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -2.07072
RAB4B RAB4B, member RAS oncogene family -2.07053
CHEK2 checkpoint kinase 2 -2.068
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.06666
RRAGB Ras-related GTP binding B -2.06605
NMBR neuromedin B receptor -2.06448
VASH2 vasohibin 2 -2.06313
HNF4G hepatocyte nuclear factor 4, gamma -2.06151
FGL2 fibrinogen-like 2 -2.05853
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.05797
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.05714
NPTX1 neuronal pentraxin I -2.05089
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.04978
CARTPT CART prepropeptide -2.04056
FAM114A1 family with sequence similarity 114, member A1 -2.0403
TMEM53 transmembrane protein 53 -2.03799
OR2B2 olfactory receptor, family 2, subfamily B, member 2 -2.03582
IFNA16 interferon, alpha 16 -2.03203
NRTN neurturin -2.03135
HSPB1 heat shock 27kDa protein 1 -2.03072
HYDIN HYDIN, axonemal central pair apparatus protein -2.02938
CPLX2 complexin 2 -2.02756
CSH2 chorionic somatomammotropin hormone 2 -2.02232
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.02134
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.0199
ANGPT4 angiopoietin 4 -2.0186
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.01678
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.01578
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.00772
ELOVL2 ELOVL fatty acid elongase 2 -2.00407