CRCGN009_HEPG2_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl parathion 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN009_HEPG2_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 7.55451
RPP38 ribonuclease P/MRP 38kDa subunit 5.70729
E2F2 E2F transcription factor 2 5.17599
UBQLN2 ubiquilin 2 4.7331
PNKP polynucleotide kinase 3'-phosphatase 4.36352
MSRA methionine sulfoxide reductase A 4.1962
CBR3 carbonyl reductase 3 4.13638
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.73824
NOSIP nitric oxide synthase interacting protein 3.68454
CCL2 chemokine (C-C motif) ligand 2 3.55064
MAP7 microtubule-associated protein 7 3.52673
HLA-DMA major histocompatibility complex, class II, DM alpha 3.4357
LOC122526780 uncharacterized LOC122526780 3.40227
KLHL9 kelch-like family member 9 3.23247
WDR7 WD repeat domain 7 3.20452
GARRE1 granule associated Rac and RHOG effector 1 3.17424
GPATCH8 G patch domain containing 8 3.14898
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.99714
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.70018
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.65006
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.47267
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.44024
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.3573
BAHCC1 BAH domain and coiled-coil containing 1 2.34741
LYSET lysosomal enzyme trafficking factor 2.28398
CDC45 cell division cycle 45 2.22314
SNX7 sorting nexin 7 2.22069
SAC3D1 SAC3 domain containing 1 2.21265
RANGRF RAN guanine nucleotide release factor 2.19425
MAST2 microtubule associated serine/threonine kinase 2 2.17408
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.1329
CKM creatine kinase, muscle 2.04971
SLN sarcolipin 2.04932
PAEP progestagen-associated endometrial protein 2.03642

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.214
CSK c-src tyrosine kinase -4.57276
CD320 CD320 molecule -4.11146
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.97607
PEG10 paternally expressed 10 -3.93793
LDHD lactate dehydrogenase D -3.84709
TWF2 twinfilin actin binding protein 2 -3.68947
GNAS GNAS complex locus -3.68849
NT5DC2 5'-nucleotidase domain containing 2 -3.35902
CRELD2 cysteine-rich with EGF-like domains 2 -3.22738
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.05022
FBXL12 F-box and leucine-rich repeat protein 12 -2.8575
SYNGR3 synaptogyrin 3 -2.59878
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.58682
FBXO7 F-box protein 7 -2.47934
INA internexin neuronal intermediate filament protein, alpha -2.39006
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.38201
CHIC2 cysteine-rich hydrophobic domain 2 -2.3501
TRAPPC6A trafficking protein particle complex 6A -2.31033
PPOX protoporphyrinogen oxidase -2.27981
COG7 component of oligomeric golgi complex 7 -2.25499
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.20634
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.19539
MTMR14 myotubularin related protein 14 -2.18665
TRAP1 TNF receptor-associated protein 1 -2.18589
EIF5 eukaryotic translation initiation factor 5 -2.13804
TAGLN2 transgelin 2 -2.07124
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.02502
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.01234
CCNH cyclin H -2.00075