CRCGN009_HEPG2_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN009_HEPG2_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 7.15505
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.1501
RPP38 ribonuclease P/MRP 38kDa subunit 7.10204
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.6388
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 5.34388
MYLK myosin light chain kinase 4.28571
BACE2 beta-site APP-cleaving enzyme 2 4.1555
ADGRE5 adhesion G protein-coupled receptor E5 4.04918
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.98295
LPAR2 lysophosphatidic acid receptor 2 3.80838
ADRB2 adrenoceptor beta 2, surface 3.35709
HSPA1A heat shock 70kDa protein 1A 3.20476
CCNA1 cyclin A1 3.08949
CIAO3 cytosolic iron-sulfur assembly component 3 2.96404
MAP7 microtubule-associated protein 7 2.93098
GPER1 G protein-coupled estrogen receptor 1 2.87167
PPARG peroxisome proliferator-activated receptor gamma 2.78123
DIPK1A divergent protein kinase domain 1A 2.70517
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.61304
ICAM1 intercellular adhesion molecule 1 2.59761
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.56114
LAGE3 L antigen family, member 3 2.55986
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.54788
MEF2C myocyte enhancer factor 2C 2.53915
HLA-DMA major histocompatibility complex, class II, DM alpha 2.51578
CNPY3 canopy FGF signaling regulator 3 2.49601
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.48808
PLSCR3 phospholipid scramblase 3 2.48146
DENND2D DENN/MADD domain containing 2D 2.44636
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.40671
TATDN2 TatD DNase domain containing 2 2.38923
NOTCH1 notch 1 2.38797
HOXA10 homeobox A10 2.37251
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.33309
SCRN1 secernin 1 2.30323
POGLUT1 protein O-glucosyltransferase 1 2.2588
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.23056
WNT10B wingless-type MMTV integration site family, member 10B 2.22826
RIGI RNA sensor RIG-I 2.18229
LSR lipolysis stimulated lipoprotein receptor 2.14737
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.12193
NOSIP nitric oxide synthase interacting protein 2.11666
ANO1 anoctamin 1, calcium activated chloride channel 2.08583
MX1 MX dynamin-like GTPase 1 2.08207
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.06392
MX2 MX dynamin-like GTPase 2 2.05791
NSUN5 NOP2/Sun domain family, member 5 2.02623
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.00349
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.00309

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -7.07401
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.77426
CDC25B cell division cycle 25B -5.43999
CCNB2 cyclin B2 -4.45826
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.13054
RAI14 retinoic acid induced 14 -3.71275
INPP1 inositol polyphosphate-1-phosphatase -3.62177
TLR4 toll-like receptor 4 -3.36813
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.15142
EGF epidermal growth factor -3.07654
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.95448
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.95242
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.91603
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.86925
ENOPH1 enolase-phosphatase 1 -2.83024
FBXO7 F-box protein 7 -2.79317
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.76119
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.6936
GTPBP8 GTP-binding protein 8 (putative) -2.63624
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.62954
CCDC86 coiled-coil domain containing 86 -2.62811
PCNA proliferating cell nuclear antigen -2.60835
DCK deoxycytidine kinase -2.60206
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.44681
YME1L1 YME1-like 1 ATPase -2.43813
TLCD3A TLC domain containing 3A -2.4033
RNF167 ring finger protein 167 -2.33088
TRAP1 TNF receptor-associated protein 1 -2.17142
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.12422
CRYL1 crystallin, lambda 1 -2.11443
CBR1 carbonyl reductase 1 -2.09048
MPC2 mitochondrial pyruvate carrier 2 -2.04592
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.0445
ITGB1BP1 integrin beta 1 binding protein 1 -2.02487
PKD2L1 polycystic kidney disease 2-like 1 -2.01858
TICAM1 toll-like receptor adaptor molecule 1 -2.0135