CRCGN009_HEPG2_24H:B05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN009_HEPG2_24H:B05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 7.01918
NOTCH1 notch 1 6.71611
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.55042
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 6.52011
CIAO3 cytosolic iron-sulfur assembly component 3 6.32198
HEBP1 heme binding protein 1 4.13072
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.79664
AMDHD2 amidohydrolase domain containing 2 3.75535
ADAM10 ADAM metallopeptidase domain 10 3.66824
PPARG peroxisome proliferator-activated receptor gamma 3.44115
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.42057
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.37514
RPL39L ribosomal protein L39-like 3.3665
BACE2 beta-site APP-cleaving enzyme 2 3.25055
CARMIL1 capping protein regulator and myosin 1 linker 1 3.0236
PMM2 phosphomannomutase 2 2.79235
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.77059
ABHD6 abhydrolase domain containing 6 2.76286
MAP7 microtubule-associated protein 7 2.62593
BZW2 basic leucine zipper and W2 domains 2 2.41589
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.35161
HOXA10 homeobox A10 2.28194
LPAR2 lysophosphatidic acid receptor 2 2.20685
CLCN5 chloride channel, voltage-sensitive 5 2.07803
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 2.03228
GPER1 G protein-coupled estrogen receptor 1 2.00416

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -6.74599
THAP11 THAP domain containing 11 -6.69103
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.08679
GNAS GNAS complex locus -5.52214
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.64957
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.56749
DNM1L dynamin 1-like -4.08205
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.96448
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.84151
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.79099
MRPS16 mitochondrial ribosomal protein S16 -3.71852
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.52714
ZMIZ1 zinc finger, MIZ-type containing 1 -3.38176
C2CD5 C2 calcium-dependent domain containing 5 -2.76572
MRPS2 mitochondrial ribosomal protein S2 -2.57075
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.52025
EGF epidermal growth factor -2.42758
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.41314
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.32513
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.24806
NBEA neurobeachin -2.22797
CA8 carbonic anhydrase VIII -2.13664
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.11891
NCKAP1 NCK-associated protein 1 -2.07458
ZNF586 zinc finger protein 586 -2.06319
DUSP10 dual specificity phosphatase 10 -2.06265
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.05585
PAIP1 poly(A) binding protein interacting protein 1 -2.04339
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -2.03949
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.01515
LGALS1 lectin, galactoside-binding, soluble, 1 -2.00613