CRCGN009_HEPG2_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aramite 0.01 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN009_HEPG2_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.63855
CDPF1 cysteine-rich, DPF motif domain containing 1 6.44727
MAP7 microtubule-associated protein 7 4.9317
CCL2 chemokine (C-C motif) ligand 2 4.63037
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 4.58066
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.35502
CBR3 carbonyl reductase 3 4.06334
ADRB2 adrenoceptor beta 2, surface 3.93673
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.9067
KLHL21 kelch-like family member 21 3.72074
ANO1 anoctamin 1, calcium activated chloride channel 3.65403
LPAR2 lysophosphatidic acid receptor 2 3.60579
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.5318
PNKP polynucleotide kinase 3'-phosphatase 3.48683
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.27121
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.11609
ZFP36 ZFP36 ring finger protein 2.92499
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.86491
PEX11A peroxisomal biogenesis factor 11 alpha 2.66706
DIPK1A divergent protein kinase domain 1A 2.66133
GPER1 G protein-coupled estrogen receptor 1 2.34596
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.11326
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.0502

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.13838
TLR4 toll-like receptor 4 -5.01214
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.95625
UBE3C ubiquitin protein ligase E3C -4.76949
CSK c-src tyrosine kinase -4.38422
NGRN neugrin, neurite outgrowth associated -4.21457
PLK1 polo-like kinase 1 -4.19568
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.10393
TSPAN4 tetraspanin 4 -4.0487
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.01702
SCAND1 SCAN domain containing 1 -3.97319
KDM3A lysine (K)-specific demethylase 3A -3.95661
CCNB2 cyclin B2 -3.9045
PCNA proliferating cell nuclear antigen -3.62275
CDC25B cell division cycle 25B -3.46056
ADI1 acireductone dioxygenase 1 -3.43095
ZW10 zw10 kinetochore protein -3.34521
TM9SF2 transmembrane 9 superfamily member 2 -3.00243
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.92871
PLA2G15 phospholipase A2, group XV -2.51908
TCEAL4 transcription elongation factor A (SII)-like 4 -2.47168
DCK deoxycytidine kinase -2.23267
SLC35F2 solute carrier family 35, member F2 -2.19497
EXT1 exostosin glycosyltransferase 1 -2.18681
RNF167 ring finger protein 167 -2.17813
TBX2 T-box 2 -2.14529
TCTN1 tectonic family member 1 -2.1401
REEP5 receptor accessory protein 5 -2.10908
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.0922
RPS5 ribosomal protein S5 -2.06655