CRCGN009_HEPG2_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aramite 0.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN009_HEPG2_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 7.64109
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 7.28794
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 7.28377
LCN2 lipocalin 2 5.86903
MOK MOK protein kinase 4.59816
ABHD6 abhydrolase domain containing 6 4.17084
STIMATE STIM activating enhancer 3.91259
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.44821
CBR3 carbonyl reductase 3 3.3435
GPER1 G protein-coupled estrogen receptor 1 3.20468
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.01202
GPATCH8 G patch domain containing 8 2.90354
LOC122526780 uncharacterized LOC122526780 2.86237
KLHL9 kelch-like family member 9 2.74313
EVL Enah/Vasp-like 2.71663
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.51195
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.39568
GATA2 GATA binding protein 2 2.39339
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.13001
KIF14 kinesin family member 14 2.0987

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.26712
TLCD3A TLC domain containing 3A -6.31602
LDHD lactate dehydrogenase D -6.03892
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.59032
GOLT1B golgi transport 1B -5.4057
PCNA proliferating cell nuclear antigen -4.98412
RAI14 retinoic acid induced 14 -4.1836
KDM3A lysine (K)-specific demethylase 3A -4.17498
DERA deoxyribose-phosphate aldolase (putative) -3.98653
TLR4 toll-like receptor 4 -3.95358
HMG20B high mobility group 20B -3.67073
FGFR4 fibroblast growth factor receptor 4 -3.39925
FBXL12 F-box and leucine-rich repeat protein 12 -3.11553
TES testin LIM domain protein -3.07149
TXNDC9 thioredoxin domain containing 9 -2.93864
SLC35F2 solute carrier family 35, member F2 -2.87992
SESN1 sestrin 1 -2.30041
CCR9 chemokine (C-C motif) receptor 9 -2.25946
ITGB1BP1 integrin beta 1 binding protein 1 -2.22743
AKR1C3 aldo-keto reductase family 1, member C3 -2.13472
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.10526
EHD4 EH-domain containing 4 -2.05221
RERGL RERG/RAS-like -2.03196