CRCGN009_HEPG2_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aramite 0.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN009_HEPG2_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.63403
GPER1 G protein-coupled estrogen receptor 1 5.34832
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.04305
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.5681
CCL2 chemokine (C-C motif) ligand 2 4.54687
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.47985
MAP7 microtubule-associated protein 7 4.26919
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.11288
PPARG peroxisome proliferator-activated receptor gamma 3.90589
CXCR4 chemokine (C-X-C motif) receptor 4 3.69732
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.54291
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.30726
VGLL4 vestigial-like family member 4 3.25957
ZFP36 ZFP36 ring finger protein 3.07274
NOSIP nitric oxide synthase interacting protein 2.77071
MEST mesoderm specific transcript 2.74694
GATA2 GATA binding protein 2 2.71503
SOCS2 suppressor of cytokine signaling 2 2.57837
LPAR2 lysophosphatidic acid receptor 2 2.47238
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.45873
LOC122526780 uncharacterized LOC122526780 2.34541
NUP133 nucleoporin 133kDa 2.26413
ZNF318 zinc finger protein 318 2.14893
CDK19 cyclin-dependent kinase 19 2.14718
ZHX2 zinc fingers and homeoboxes 2 2.10293
JADE2 jade family PHD finger 2 2.03088

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.36324
ADI1 acireductone dioxygenase 1 -5.48789
KDM3A lysine (K)-specific demethylase 3A -5.42977
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.18733
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.00568
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.9923
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.9259
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.63137
TLR4 toll-like receptor 4 -3.96993
DERA deoxyribose-phosphate aldolase (putative) -3.93465
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.66986
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.48971
EIF5 eukaryotic translation initiation factor 5 -3.27768
SLC35F2 solute carrier family 35, member F2 -2.89949
DCK deoxycytidine kinase -2.76954
RFC2 replication factor C (activator 1) 2, 40kDa -2.75126
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.36576
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.35507
EXT1 exostosin glycosyltransferase 1 -2.26115
ZNF134 zinc finger protein 134 -2.21267
FOS FBJ murine osteosarcoma viral oncogene homolog -2.20571
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -2.15436
ZNF551 zinc finger protein 551 -2.1486
TM9SF3 transmembrane 9 superfamily member 3 -2.137
SIX6 SIX homeobox 6 -2.1329
CXCL2 chemokine (C-X-C motif) ligand 2 -2.07734
CLTCL1 clathrin, heavy chain-like 1 -2.07028
GGT5 gamma-glutamyltransferase 5 -2.0494