CRCGN009_HEPG2_24H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenoxyacetic acid 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.63988
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.69196
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.65044
DIPK1A divergent protein kinase domain 1A 4.21505
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.19469
MYLK myosin light chain kinase 4.05902
CARMIL1 capping protein regulator and myosin 1 linker 1 3.96867
CCL2 chemokine (C-C motif) ligand 2 3.90684
UBQLN2 ubiquilin 2 3.87737
RPL39L ribosomal protein L39-like 3.76631
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.38888
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.07261
CHMP6 charged multivesicular body protein 6 2.87951
HEBP1 heme binding protein 1 2.72801
KDM5A lysine (K)-specific demethylase 5A 2.62747
CXCL2 chemokine (C-X-C motif) ligand 2 2.514
NOSIP nitric oxide synthase interacting protein 2.48181
MAP7 microtubule-associated protein 7 2.47047
BAX BCL2-associated X protein 2.45294
TENT4A terminal nucleotidyltransferase 4A 2.42102
PPARG peroxisome proliferator-activated receptor gamma 2.36331
SMAD3 SMAD family member 3 2.30979
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.17272
TIAM1 T-cell lymphoma invasion and metastasis 1 2.16181
BPHL biphenyl hydrolase-like (serine hydrolase) 2.09847

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.12487
MRPS2 mitochondrial ribosomal protein S2 -6.22043
TLCD3A TLC domain containing 3A -4.97021
COG2 component of oligomeric golgi complex 2 -4.8252
CSK c-src tyrosine kinase -4.32195
UBE3C ubiquitin protein ligase E3C -4.20566
CDC20 cell division cycle 20 -4.10186
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.80438
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.51805
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.35015
ENOPH1 enolase-phosphatase 1 -3.33447
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.19662
TLR4 toll-like receptor 4 -3.17565
LDHD lactate dehydrogenase D -2.98409
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.93186
EIF5 eukaryotic translation initiation factor 5 -2.925
ZMIZ1 zinc finger, MIZ-type containing 1 -2.91234
ITGB1BP1 integrin beta 1 binding protein 1 -2.86973
VDAC1 voltage-dependent anion channel 1 -2.84553
UGDH UDP-glucose 6-dehydrogenase -2.80431
TRIB3 tribbles pseudokinase 3 -2.70281
CCNB2 cyclin B2 -2.62033
KDM3A lysine (K)-specific demethylase 3A -2.43827
OXA1L oxidase (cytochrome c) assembly 1-like -2.39555
ZW10 zw10 kinetochore protein -2.37975
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.27272
FASTKD5 FAST kinase domains 5 -2.20759
NRIP1 nuclear receptor interacting protein 1 -2.19046
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.10723
EGF epidermal growth factor -2.0756
ZNF586 zinc finger protein 586 -2.06962
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.06292
BIN2 bridging integrator 2 -2.05837
PAEP progestagen-associated endometrial protein -2.05713
PRPF4 pre-mRNA processing factor 4 -2.05089