CRCGN009_HEPG2_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenoxyacetic acid 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN009_HEPG2_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.68522
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.15892
ABHD6 abhydrolase domain containing 6 5.05637
CIAO3 cytosolic iron-sulfur assembly component 3 4.04306
JADE2 jade family PHD finger 2 3.99552
CCNF cyclin F 3.70093
DYNLT3 dynein, light chain, Tctex-type 3 3.55837
STK10 serine/threonine kinase 10 3.50393
ALDOC aldolase C, fructose-bisphosphate 3.4711
LCN2 lipocalin 2 3.42164
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.20995
TRIM13 tripartite motif containing 13 3.20404
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.18043
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.06133
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.76919
C2CD2 C2 calcium-dependent domain containing 2 2.74272
CLOCK clock circadian regulator 2.59726
MICALL1 MICAL-like 1 2.4895
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.48621
CEMIP2 cell migration inducing hyaluronidase 2 2.4489
MCM3 minichromosome maintenance complex component 3 2.40301
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.2832
GPER1 G protein-coupled estrogen receptor 1 2.20313
MAP7 microtubule-associated protein 7 2.12677
GSTZ1 glutathione S-transferase zeta 1 2.09976
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.03156
CORO1A coronin, actin binding protein, 1A 2.00486

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.60104
LDHD lactate dehydrogenase D -6.58166
PCNA proliferating cell nuclear antigen -6.18117
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.11853
CHMP4B charged multivesicular body protein 4B -5.74229
TLR4 toll-like receptor 4 -5.32955
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.83949
CCNB2 cyclin B2 -4.5828
UGDH UDP-glucose 6-dehydrogenase -4.37631
ZMIZ1 zinc finger, MIZ-type containing 1 -3.77488
FBXL12 F-box and leucine-rich repeat protein 12 -3.73283
DSG2 desmoglein 2 -3.70939
OXA1L oxidase (cytochrome c) assembly 1-like -3.49598
RFC2 replication factor C (activator 1) 2, 40kDa -3.40847
TRIB3 tribbles pseudokinase 3 -3.38346
KDM3A lysine (K)-specific demethylase 3A -3.34997
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.31402
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.25596
CDC20 cell division cycle 20 -3.2215
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.1756
MRPS2 mitochondrial ribosomal protein S2 -3.13516
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.10384
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.02905
VAT1 vesicle amine transport 1 -2.94626
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.89213
GNAS GNAS complex locus -2.77266
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.68371
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.56336
YME1L1 YME1-like 1 ATPase -2.54728
SNX11 sorting nexin 11 -2.51438
PEG10 paternally expressed 10 -2.48814
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.37301
ZNF134 zinc finger protein 134 -2.30577
TOR1A torsin family 1, member A (torsin A) -2.23932
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.13147
TLCD3A TLC domain containing 3A -2.09014
ENDOG endonuclease G -2.04166
COQ4 coenzyme Q4 -2.02116
ZNF239 zinc finger protein 239 -2.00903