CRCGN009_HEPG2_24H:B18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenoxyacetic acid 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:B18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BLMH bleomycin hydrolase 6.61572
GPER1 G protein-coupled estrogen receptor 1 6.03841
SFTPB surfactant protein B 5.17765
PPARG peroxisome proliferator-activated receptor gamma 5.0993
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.99099
BACE2 beta-site APP-cleaving enzyme 2 4.89032
CHN1 chimerin 1 4.77186
SMIM40 small integral membrane protein 40 4.6808
C2CD2 C2 calcium-dependent domain containing 2 4.47579
PNKP polynucleotide kinase 3'-phosphatase 4.33824
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.96627
VAV3 vav 3 guanine nucleotide exchange factor 3.85933
SQOR sulfide quinone oxidoreductase 3.61156
UBE2A ubiquitin-conjugating enzyme E2A 3.59561
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.56235
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.56102
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.5251
TIAM1 T-cell lymphoma invasion and metastasis 1 3.51907
VGLL4 vestigial-like family member 4 3.26445
HLA-DMA major histocompatibility complex, class II, DM alpha 3.22677
MAP7 microtubule-associated protein 7 3.15478
CYCS cytochrome c, somatic 3.11642
GARRE1 granule associated Rac and RHOG effector 1 3.07817
ABHD4 abhydrolase domain containing 4 2.98898
KDM5A lysine (K)-specific demethylase 5A 2.98069
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.57761
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.51829
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.51282
GPATCH8 G patch domain containing 8 2.35873
NUP133 nucleoporin 133kDa 2.27375
GSK3B glycogen synthase kinase 3 beta 2.23917
USP39 ubiquitin specific peptidase 39 2.15789
EPHA3 EPH receptor A3 2.12892
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.03062
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.00603

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -9.05714
PCNA proliferating cell nuclear antigen -8.21514
PTPRK protein tyrosine phosphatase, receptor type, K -6.01397
CD320 CD320 molecule -5.63283
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.57078
ISOC1 isochorismatase domain containing 1 -5.00262
TSPAN4 tetraspanin 4 -4.90185
CCDC86 coiled-coil domain containing 86 -4.87874
LDHD lactate dehydrogenase D -4.66686
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.54311
COG2 component of oligomeric golgi complex 2 -3.85411
PECR peroxisomal trans-2-enoyl-CoA reductase -3.76501
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.63982
RNF167 ring finger protein 167 -3.61293
GOLT1B golgi transport 1B -3.60076
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.41032
OXA1L oxidase (cytochrome c) assembly 1-like -3.03699
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.8996
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.64539
SPAG4 sperm associated antigen 4 -2.62629
CHIC2 cysteine-rich hydrophobic domain 2 -2.53838
ARID5B AT rich interactive domain 5B (MRF1-like) -2.42325
FLNA filamin A, alpha -2.21204
BIRC2 baculoviral IAP repeat containing 2 -2.20035
REEP5 receptor accessory protein 5 -2.03254