CRCGN009_HEPG2_24H:B21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolbutamide 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN009_HEPG2_24H:B21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 6.90384
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.84909
PRR15L proline rich 15-like 4.19886
CDPF1 cysteine-rich, DPF motif domain containing 1 4.12491
LPAR2 lysophosphatidic acid receptor 2 3.82257
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.45887
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.40986
MAP7 microtubule-associated protein 7 3.34837
ADAM10 ADAM metallopeptidase domain 10 3.24098
GPATCH8 G patch domain containing 8 2.90624
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.65688
NOSIP nitric oxide synthase interacting protein 2.38189
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.29321
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.18642
SIRT3 sirtuin 3 2.15437
JADE2 jade family PHD finger 2 2.059

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.4733
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.23215
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.01812
DSG2 desmoglein 2 -4.97311
SCAND1 SCAN domain containing 1 -4.89815
NGRN neugrin, neurite outgrowth associated -4.85995
LOC124907782 dual specificity protein phosphatase 22 -4.78262
OXA1L oxidase (cytochrome c) assembly 1-like -4.76102
TUBB6 tubulin, beta 6 class V -4.70663
CDC20 cell division cycle 20 -4.44578
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.44389
FGFR4 fibroblast growth factor receptor 4 -4.03284
CSK c-src tyrosine kinase -3.93228
PEG10 paternally expressed 10 -3.53292
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.35807
MTFR1 mitochondrial fission regulator 1 -3.222
SNX11 sorting nexin 11 -2.92844
PRPF4 pre-mRNA processing factor 4 -2.72749
TLCD3A TLC domain containing 3A -2.71643
LDHD lactate dehydrogenase D -2.44476
TLR4 toll-like receptor 4 -2.32996
EGF epidermal growth factor -2.13425
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.04597
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.02847