| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tolbutamide 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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62 genes differentially expressed following the CRCGN009_HEPG2_24H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYLK | myosin light chain kinase | 5.97424 |
| EPN2 | epsin 2 | 5.10772 |
| LCN2 | lipocalin 2 | 4.94189 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.66456 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.59044 |
| RPL39L | ribosomal protein L39-like | 4.46567 |
| MAMLD1 | mastermind-like domain containing 1 | 4.18787 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.16782 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.15308 |
| CYCS | cytochrome c, somatic | 3.97293 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.94887 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.89762 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.89231 |
| CHMP6 | charged multivesicular body protein 6 | 3.86916 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.80964 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.78167 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.66827 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 3.55923 |
| E2F2 | E2F transcription factor 2 | 3.46948 |
| MOK | MOK protein kinase | 3.41415 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.16905 |
| HOOK2 | hook microtubule-tethering protein 2 | 2.76378 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.60842 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.58308 |
| RHOA | ras homolog family member A | 2.56852 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.54064 |
| GATA2 | GATA binding protein 2 | 2.4189 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.39317 |
| HOXA10 | homeobox A10 | 2.33366 |
| CHN1 | chimerin 1 | 2.29211 |
| MRPL17 | mitochondrial ribosomal protein L17 | 2.21954 |
| SFTPB | surfactant protein B | 2.14292 |
| FAM216A | family with sequence similarity 216, member A | 2.09912 |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | 2.02664 |
| BLM | Bloom syndrome, RecQ helicase-like | 2.01539 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -7.87781 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.29292 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -5.22327 |
| ZNF586 | zinc finger protein 586 | -4.89915 |
| TLR4 | toll-like receptor 4 | -4.86103 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.93236 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.90788 |
| TMEM109 | transmembrane protein 109 | -3.80974 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.64519 |
| RAI14 | retinoic acid induced 14 | -3.23214 |
| CCNB1 | cyclin B1 | -3.21612 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -3.2157 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.09401 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.87441 |
| YME1L1 | YME1-like 1 ATPase | -2.85133 |
| WDR7 | WD repeat domain 7 | -2.83819 |
| EGF | epidermal growth factor | -2.76231 |
| HYOU1 | hypoxia up-regulated 1 | -2.50814 |
| MACF1 | microtubule-actin crosslinking factor 1 | -2.29791 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.28498 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.25503 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.25502 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.1426 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.13933 |
| IL20RA | interleukin 20 receptor, alpha | -2.06038 |
| GRAP2 | GRB2-related adaptor protein 2 | -2.03736 |
| ACLY | ATP citrate lyase | -2.01796 |
