CRCGN009_HEPG2_24H:C01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN009_HEPG2_24H:C01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 5.29418
NUCB2 nucleobindin 2 5.14155
ABHD4 abhydrolase domain containing 4 5.02705
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.84041
UGDH UDP-glucose 6-dehydrogenase 4.70979
CTSL cathepsin L 4.6861
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.11595
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.67957
MVP major vault protein 3.42399
CBR1 carbonyl reductase 1 3.19436
SFTPB surfactant protein B 3.17614
TRIB3 tribbles pseudokinase 3 3.15403
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.0079
CDC45 cell division cycle 45 2.90831
DIPK1A divergent protein kinase domain 1A 2.74066
AXIN1 axin 1 2.72848
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.67549
PTK2 protein tyrosine kinase 2 2.55807
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.40342
SLC25A46 solute carrier family 25, member 46 2.39711
NPDC1 neural proliferation, differentiation and control, 1 2.39546
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.34963
CCP110 centriolar coiled coil protein 110kDa 2.32788
ECH1 enoyl CoA hydratase 1, peroxisomal 2.31754
MAST2 microtubule associated serine/threonine kinase 2 2.26676
MCM3 minichromosome maintenance complex component 3 2.23891
SQSTM1 sequestosome 1 2.22352
TWF2 twinfilin actin binding protein 2 2.22343
WDR7 WD repeat domain 7 2.18447
PRELID3A PRELI domain containing 3A 2.1692
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.12712
MBNL1 muscleblind-like splicing regulator 1 2.12089
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.12059
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.07654
PEX11B peroxisomal biogenesis factor 11 beta 2.04612
YIPF3 Yip1 domain family, member 3 2.0439
FOXO4 forkhead box O4 2.04352
RAB21 RAB21, member RAS oncogene family 2.0322
MEST mesoderm specific transcript 2.0024

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.93726
CDC20 cell division cycle 20 -6.30917
SLC35F2 solute carrier family 35, member F2 -4.68829
CDK1 cyclin-dependent kinase 1 -4.25637
PSRC1 proline/serine-rich coiled-coil 1 -4.19529
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.15984
TOP2A topoisomerase (DNA) II alpha 170kDa -3.89085
CCNB2 cyclin B2 -3.64961
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.59438
CCNA2 cyclin A2 -3.52188
MELK maternal embryonic leucine zipper kinase -3.31851
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.12901
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.12674
PLK1 polo-like kinase 1 -3.1266
LDHD lactate dehydrogenase D -3.12647
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.09466
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.99222
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.91823
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.80361
UBE2C ubiquitin-conjugating enzyme E2C -2.79593
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.69835
AURKB aurora kinase B -2.65661
GTF2A2 general transcription factor IIA, 2, 12kDa -2.64448
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.60063
SESN1 sestrin 1 -2.56212
CCNB1 cyclin B1 -2.54342
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.51226
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.47279
UBE3C ubiquitin protein ligase E3C -2.47267
DCK deoxycytidine kinase -2.47045
GRWD1 glutamate-rich WD repeat containing 1 -2.40011
BIRC5 baculoviral IAP repeat containing 5 -2.39853
PGAM4 phosphoglycerate mutase family member 4 -2.3662
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.36423
VAT1 vesicle amine transport 1 -2.34151
MSX2 msh homeobox 2 -2.33826
CHEK1 checkpoint kinase 1 -2.28358
AKAP8 A kinase (PRKA) anchor protein 8 -2.26481
RPIA ribose 5-phosphate isomerase A -2.25394
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.22705
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.2239
DBF4 DBF4 zinc finger -2.21672
LBR lamin B receptor -2.20788
MTA1 metastasis associated 1 -2.1848
EGF epidermal growth factor -2.17992
KIF14 kinesin family member 14 -2.16786
TUBB6 tubulin, beta 6 class V -2.14212
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.10134
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 -2.09534
NLRP2B NLR family pyrin domain containing 2B -2.07155
HDAC2 histone deacetylase 2 -2.04436
GLOD4 glyoxalase domain containing 4 -2.02758
ZNF274 zinc finger protein 274 -2.02682
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.01837
ZNF586 zinc finger protein 586 -2.00994