CRCGN009_HEPG2_24H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN009_HEPG2_24H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.87765
MAP7 microtubule-associated protein 7 4.9392
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.71034
TXNRD1 thioredoxin reductase 1 4.33065
GPATCH8 G patch domain containing 8 4.01065
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.90493
CRTAP cartilage associated protein 3.74692
ATP11B ATPase, class VI, type 11B 3.61227
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.5991
CARMIL1 capping protein regulator and myosin 1 linker 1 3.48988
CBR3 carbonyl reductase 3 3.42814
HLA-DMA major histocompatibility complex, class II, DM alpha 3.23539
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.1619
MCM3 minichromosome maintenance complex component 3 3.13399
CYCS cytochrome c, somatic 3.04975
BACE2 beta-site APP-cleaving enzyme 2 3.04379
ABHD4 abhydrolase domain containing 4 3.0335
RPP38 ribonuclease P/MRP 38kDa subunit 2.96956
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.72478
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.69172
CTSL cathepsin L 2.67681
SLC75A1 solute carrier family 75 member 1 2.62085
PTK2 protein tyrosine kinase 2 2.55223
PMM2 phosphomannomutase 2 2.45356
MEST mesoderm specific transcript 2.40555
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.34922
KLHDC2 kelch domain containing 2 2.28613
RAP1GAP RAP1 GTPase activating protein 2.22314
NIT1 nitrilase 1 2.17506
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.14848
UGDH UDP-glucose 6-dehydrogenase 2.12892
ADGRG1 adhesion G protein-coupled receptor G1 2.09829
ERBIN erbb2 interacting protein 2.08455
MVP major vault protein 2.03105

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.02548
TLCD3A TLC domain containing 3A -5.31291
CDC20 cell division cycle 20 -5.26642
CCNB2 cyclin B2 -4.64369
PRPF4 pre-mRNA processing factor 4 -4.05397
PCCB propionyl CoA carboxylase, beta polypeptide -3.59126
ADI1 acireductone dioxygenase 1 -3.56051
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.48258
LDHD lactate dehydrogenase D -3.4121
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.37125
CHMP4B charged multivesicular body protein 4B -3.02676
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.85961
CD320 CD320 molecule -2.80603
TXNDC9 thioredoxin domain containing 9 -2.74543
SNX11 sorting nexin 11 -2.57579
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.43269
RNF167 ring finger protein 167 -2.39518
LOC124907782 dual specificity protein phosphatase 22 -2.39437
PSRC1 proline/serine-rich coiled-coil 1 -2.36278
GNAS GNAS complex locus -2.32491
NGRN neugrin, neurite outgrowth associated -2.25856
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.18588
CDK1 cyclin-dependent kinase 1 -2.12432
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.05611
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.04101