CRCGN009_HEPG2_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN009_HEPG2_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.75415
C2CD2 C2 calcium-dependent domain containing 2 4.58997
PEX11A peroxisomal biogenesis factor 11 alpha 4.58626
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.36864
PPARG peroxisome proliferator-activated receptor gamma 4.30196
MYLK myosin light chain kinase 4.13144
TIAM1 T-cell lymphoma invasion and metastasis 1 3.54531
CORO1A coronin, actin binding protein, 1A 3.32401
LOC122526780 uncharacterized LOC122526780 3.27076
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2293
NOTCH1 notch 1 3.19334
WDR7 WD repeat domain 7 2.97381
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.94355
RXYLT1 ribitol xylosyltransferase 1 2.82903
FZD7 frizzled class receptor 7 2.82482
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.39162
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.34916
EPHB2 EPH receptor B2 2.28164
HLA-DRA major histocompatibility complex, class II, DR alpha 2.27914
DPH2 DPH2 homolog (S. cerevisiae) 2.25286
AKTIP AKT interacting protein 2.24521
OSTF1 osteoclast stimulating factor 1 2.1366
CCL2 chemokine (C-C motif) ligand 2 2.09732
PFKL phosphofructokinase, liver 2.09402
CNPY3 canopy FGF signaling regulator 3 2.08661
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.08442
NOSIP nitric oxide synthase interacting protein 2.07358
TSPAN6 tetraspanin 6 2.06208
SALL1 spalt-like transcription factor 1 2.05868
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.02586

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -6.30994
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.408
VAT1 vesicle amine transport 1 -5.06029
PCNA proliferating cell nuclear antigen -3.76434
CCNB2 cyclin B2 -3.35175
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.2832
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.20297
LOC124907782 dual specificity protein phosphatase 22 -3.16079
TM9SF2 transmembrane 9 superfamily member 2 -2.93717
GNAS GNAS complex locus -2.74363
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.33221
NRIP1 nuclear receptor interacting protein 1 -2.28858
RNF167 ring finger protein 167 -2.21203
CCNB1 cyclin B1 -2.195
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.1707
BPI bactericidal/permeability-increasing protein -2.11279
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.10106
SNX11 sorting nexin 11 -2.09864