CRCGN009_HEPG2_24H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 41.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

150 genes differentially expressed following the CRCGN009_HEPG2_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.66886
UBQLN2 ubiquilin 2 7.27457
SFTPB surfactant protein B 5.52074
CHMP6 charged multivesicular body protein 6 5.37646
MAP7 microtubule-associated protein 7 5.04106
AMDHD2 amidohydrolase domain containing 2 5.03677
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.89233
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.823
E2F2 E2F transcription factor 2 4.78839
CCDC85B coiled-coil domain containing 85B 4.4563
CBR3 carbonyl reductase 3 4.13553
EPN2 epsin 2 4.04865
PNKP polynucleotide kinase 3'-phosphatase 3.56681
TSC22D3 TSC22 domain family, member 3 3.55316
CCNA1 cyclin A1 3.41901
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.343
WDR25 WD repeat domain 25 3.28993
CYCS cytochrome c, somatic 3.20655
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.12262
GPER1 G protein-coupled estrogen receptor 1 3.076
RPL39L ribosomal protein L39-like 2.97989
TIAM1 T-cell lymphoma invasion and metastasis 1 2.93049
PPARG peroxisome proliferator-activated receptor gamma 2.92878
BZW2 basic leucine zipper and W2 domains 2 2.80553
SIRT3 sirtuin 3 2.7887
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.69954
LOC122526780 uncharacterized LOC122526780 2.69303
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.67392
EVL Enah/Vasp-like 2.62776
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.57209
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.53572
TNP1 transition protein 1 (during histone to protamine replacement) 2.5076
MEST mesoderm specific transcript 2.49445
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.4835
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.48121
FAM246A family with sequence similarity 246 member A 2.47889
MCOLN1 mucolipin 1 2.46998
ACTL7B actin-like 7B 2.44084
EXOC3 exocyst complex component 3 2.39062
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.38899
TBPL1 TBP-like 1 2.37806
GALR3 galanin receptor 3 2.37796
TRIP13 thyroid hormone receptor interactor 13 2.36331
GSTZ1 glutathione S-transferase zeta 1 2.36177
KRT3 keratin 3, type II 2.35812
ADGRE5 adhesion G protein-coupled receptor E5 2.34492
TMCC2 transmembrane and coiled-coil domain family 2 2.3121
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.29464
SIL1 SIL1 nucleotide exchange factor 2.29174
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.28708
NKX2-1 NK2 homeobox 1 2.28193
TMPRSS11D transmembrane protease, serine 11D 2.27954
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.26922
ABHD4 abhydrolase domain containing 4 2.2655
ADGRB1 adhesion G protein-coupled receptor B1 2.25872
DIO2 deiodinase, iodothyronine, type II 2.25567
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.2353
TRAIP TRAF interacting protein 2.21341
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.18886
YIPF2 Yip1 domain family, member 2 2.18626
CEND1 cell cycle exit and neuronal differentiation 1 2.17631
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.17629
BACE2 beta-site APP-cleaving enzyme 2 2.17299
CCL24 chemokine (C-C motif) ligand 24 2.17154
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.15364
BRD9 bromodomain containing 9 2.13717
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.12471
RAB21 RAB21, member RAS oncogene family 2.12057
FRAS1 Fraser extracellular matrix complex subunit 1 2.10065
PSPN persephin 2.1001
SPRR1A small proline-rich protein 1A 2.09621
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.08924
IRGC immunity-related GTPase family, cinema 2.087
MATN4 matrilin 4 2.08598
BAALC brain and acute leukemia, cytoplasmic 2.0839
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 2.06762
FAAP24 FA core complex associated protein 24 2.0654
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.05967
DLX6 distal-less homeobox 6 2.0587
C8A complement component 8, alpha polypeptide 2.05287
DKKL1 dickkopf-like 1 2.05179
PCYT1B phosphate cytidylyltransferase 1, choline, beta 2.04884
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.04788
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.04446
ULBP2 UL16 binding protein 2 2.04443
ZNRF4 zinc and ring finger 4 2.04205
NGB neuroglobin 2.04132
INO80B INO80 complex subunit B 2.03398
FRS3 fibroblast growth factor receptor substrate 3 2.02462
OSBP2 oxysterol binding protein 2 2.0229
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.02168
CRYBA4 crystallin, beta A4 2.01694
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.01288
MNMIP1 manchette microtubule inner protein 1 2.00707
PGP phosphoglycolate phosphatase 2.00308

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -9.60958
ZNF586 zinc finger protein 586 -9.2784
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.02632
ANKRD10 ankyrin repeat domain 10 -5.00945
COG2 component of oligomeric golgi complex 2 -4.90996
THAP11 THAP domain containing 11 -4.84929
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.80615
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.57877
NISCH nischarin -4.25243
YME1L1 YME1-like 1 ATPase -3.73203
FBXL12 F-box and leucine-rich repeat protein 12 -3.627
EGF epidermal growth factor -3.4416
FGFR4 fibroblast growth factor receptor 4 -3.43374
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.3336
RFC2 replication factor C (activator 1) 2, 40kDa -3.1291
DSG2 desmoglein 2 -3.09368
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.07751
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.07668
PSRC1 proline/serine-rich coiled-coil 1 -2.85333
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.83685
VAT1 vesicle amine transport 1 -2.82071
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.78397
TOMM70 translocase of outer mitochondrial membrane 70 -2.57998
ZNF134 zinc finger protein 134 -2.56905
FOXO1 forkhead box O1 -2.38212
ADSL adenylosuccinate lyase -2.37526
SLC46A3 solute carrier family 46, member 3 -2.35574
DNM1L dynamin 1-like -2.32324
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.30161
SAMM50 SAMM50 sorting and assembly machinery component -2.29286
ARCN1 archain 1 -2.29176
OXA1L oxidase (cytochrome c) assembly 1-like -2.28097
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.2658
TM9SF2 transmembrane 9 superfamily member 2 -2.25713
ZNF551 zinc finger protein 551 -2.24338
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.20973
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.19937
SUN2 Sad1 and UNC84 domain containing 2 -2.19492
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.19481
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.18412
TRAPPC4 trafficking protein particle complex 4 -2.17546
PTPRK protein tyrosine phosphatase, receptor type, K -2.13099
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.11192
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.11042
ZNF197 zinc finger protein 197 -2.07547
CHEK1 checkpoint kinase 1 -2.06528
USPL1 ubiquitin specific peptidase like 1 -2.04595
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.04035
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.03701
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.02133
ZNF304 zinc finger protein 304 -2.02089
OLFML3 olfactomedin-like 3 -2.01446
POMP proteasome maturation protein -2.00717
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.00238