CRCGN009_HEPG2_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 20.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

109 genes differentially expressed following the CRCGN009_HEPG2_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.73437
HLA-DMA major histocompatibility complex, class II, DM alpha 6.1223
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.83083
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.4035
MYLK myosin light chain kinase 5.30213
ATP11B ATPase, class VI, type 11B 4.69198
CXCL2 chemokine (C-X-C motif) ligand 2 4.47854
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.47217
UBQLN2 ubiquilin 2 4.14217
STIMATE STIM activating enhancer 3.99968
ANO1 anoctamin 1, calcium activated chloride channel 3.9061
SFTPB surfactant protein B 3.71996
GPER1 G protein-coupled estrogen receptor 1 3.40882
IDE insulin-degrading enzyme 3.22292
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.08598
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.02088
CA4 carbonic anhydrase IV 2.95093
CCNF cyclin F 2.79137
HBB hemoglobin, beta 2.76617
HLA-DRA major histocompatibility complex, class II, DR alpha 2.7255
VGLL4 vestigial-like family member 4 2.70739
TICAM1 toll-like receptor adaptor molecule 1 2.67997
HEBP1 heme binding protein 1 2.64402
GPATCH8 G patch domain containing 8 2.61585
COL5A3 collagen, type V, alpha 3 2.56811
HBA1 hemoglobin, alpha 1 2.54242
PRR15L proline rich 15-like 2.53901
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.52169
INSL5 insulin-like 5 2.50881
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.49994
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.45779
PARD6A par-6 family cell polarity regulator alpha 2.44354
HCAR3 hydroxycarboxylic acid receptor 3 2.3855
DHDDS dehydrodolichyl diphosphate synthase 2.3831
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.37536
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.36547
COL5A2 collagen, type V, alpha 2 2.36448
VEGFD vascular endothelial growth factor D 2.32655
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.29893
CHN1 chimerin 1 2.29531
EMC10 ER membrane protein complex subunit 10 2.28743
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.27731
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.25934
HMG20A high mobility group 20A 2.24728
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.22164
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.2145
KLHL9 kelch-like family member 9 2.20715
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.18821
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.18493
AQP8 aquaporin 8 2.17476
TMEM101 transmembrane protein 101 2.1741
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.17174
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.16857
CIRBP cold inducible RNA binding protein 2.15766
PEX13 peroxisomal biogenesis factor 13 2.14347
CD177 CD177 molecule 2.13036
NHLRC2 NHL repeat containing 2 2.11285
PARP1 poly (ADP-ribose) polymerase 1 2.11231
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.1041
S1PR2 sphingosine-1-phosphate receptor 2 2.10055
IL3RA interleukin 3 receptor, alpha (low affinity) 2.09547
TRIM5 tripartite motif containing 5 2.08697
NOSIP nitric oxide synthase interacting protein 2.08038
ASPN asporin 2.06727
REPIN1 replication initiator 1 2.06234
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.06041
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.05497
PRAMEF13 PRAME family member 13 2.04219
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.03565
CLCN2 chloride channel, voltage-sensitive 2 2.03519
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.03414
CCL27 chemokine (C-C motif) ligand 27 2.025
FPGS folylpolyglutamate synthase 2.0248
SLC35F5 solute carrier family 35, member F5 2.02134
PHF24 PHD finger protein 24 2.01801
AGRP agouti related neuropeptide 2.01096
FAM174B family with sequence similarity 174, member B 2.00562
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.00324
GCG glucagon 2.00126

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -5.95073
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.46523
C2CD5 C2 calcium-dependent domain containing 5 -4.289
CCDC86 coiled-coil domain containing 86 -4.26724
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.25327
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.24576
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.20809
RFC2 replication factor C (activator 1) 2, 40kDa -4.18849
PCNA proliferating cell nuclear antigen -4.01191
SNX11 sorting nexin 11 -3.65399
HYOU1 hypoxia up-regulated 1 -3.40443
RNF167 ring finger protein 167 -3.14352
CAB39 calcium binding protein 39 -3.0118
HMG20B high mobility group 20B -2.94888
CSK c-src tyrosine kinase -2.64562
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.59041
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.4759
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.46091
ARID5B AT rich interactive domain 5B (MRF1-like) -2.45237
DSG2 desmoglein 2 -2.42858
ITGB1BP1 integrin beta 1 binding protein 1 -2.41752
TCTN1 tectonic family member 1 -2.41058
ACLY ATP citrate lyase -2.32972
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.32442
ZNF274 zinc finger protein 274 -2.19525
NRIP1 nuclear receptor interacting protein 1 -2.11712
UGDH UDP-glucose 6-dehydrogenase -2.10897
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.00943
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.00145
ZMAT5 zinc finger, matrin-type 5 -2.00028