CRCGN009_HEPG2_24H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 5.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DENND2D DENN/MADD domain containing 2D 4.43084
GPER1 G protein-coupled estrogen receptor 1 3.92516
TIAM1 T-cell lymphoma invasion and metastasis 1 3.80364
BLMH bleomycin hydrolase 3.54602
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.45308
MAMLD1 mastermind-like domain containing 1 3.37515
PRR15L proline rich 15-like 3.35656
PPARG peroxisome proliferator-activated receptor gamma 3.01253
ATP11B ATPase, class VI, type 11B 2.96858
GSTZ1 glutathione S-transferase zeta 1 2.93468
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.92768
HOXA10 homeobox A10 2.67988
MCUR1 mitochondrial calcium uniporter regulator 1 2.45294
DIPK1A divergent protein kinase domain 1A 2.39866
TRAM2 translocation associated membrane protein 2 2.39326
RRAGA Ras-related GTP binding A 2.37256
TEX10 testis expressed 10 2.23761
EVL Enah/Vasp-like 2.2245
PMM2 phosphomannomutase 2 2.21487
CYCS cytochrome c, somatic 2.17849

decreased expression

Symbol Name Standardized Value
ZMIZ1 zinc finger, MIZ-type containing 1 -5.86123
PCNA proliferating cell nuclear antigen -5.64105
TLR4 toll-like receptor 4 -5.35101
GOLT1B golgi transport 1B -4.26269
OXA1L oxidase (cytochrome c) assembly 1-like -4.05688
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.64916
CCNB2 cyclin B2 -3.37427
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.23477
ADI1 acireductone dioxygenase 1 -3.04125
PECR peroxisomal trans-2-enoyl-CoA reductase -2.92958
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.92092
PUF60 poly-U binding splicing factor 60KDa -2.89124
VAT1 vesicle amine transport 1 -2.88447
PEG10 paternally expressed 10 -2.69017
DERA deoxyribose-phosphate aldolase (putative) -2.68042
PTPRK protein tyrosine phosphatase, receptor type, K -2.63876
GNAS GNAS complex locus -2.5568
EGF epidermal growth factor -2.41717
CD320 CD320 molecule -2.28574
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.21918
RIBC2 RIB43A domain with coiled-coils 2 -2.15085
SNX11 sorting nexin 11 -2.07219