CRCGN009_HEPG2_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN009_HEPG2_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 6.25398
ADRB2 adrenoceptor beta 2, surface 5.95486
LCN2 lipocalin 2 5.887
E2F2 E2F transcription factor 2 5.53335
HLA-DMA major histocompatibility complex, class II, DM alpha 4.7947
MAMLD1 mastermind-like domain containing 1 4.56658
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.3614
PPARG peroxisome proliferator-activated receptor gamma 4.21411
MAP7 microtubule-associated protein 7 4.10226
NOTCH1 notch 1 4.06767
DYNLT3 dynein, light chain, Tctex-type 3 4.04077
RPP38 ribonuclease P/MRP 38kDa subunit 3.64704
SFTPB surfactant protein B 3.6441
ATP11B ATPase, class VI, type 11B 3.59109
PLSCR3 phospholipid scramblase 3 3.41003
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.36163
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.28548
JADE2 jade family PHD finger 2 3.23774
NOSIP nitric oxide synthase interacting protein 2.85191
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.83881
KIF20A kinesin family member 20A 2.76744
AMDHD2 amidohydrolase domain containing 2 2.69497
ICAM1 intercellular adhesion molecule 1 2.67121
PRR15L proline rich 15-like 2.59596
CRTAP cartilage associated protein 2.54781
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.49542
EGF epidermal growth factor 2.47167
COL9A2 collagen, type IX, alpha 2 2.3607
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.2884
EPHA3 EPH receptor A3 2.24547
KIF18B kinesin family member 18B 2.23395
DIPK1A divergent protein kinase domain 1A 2.21258
CCDC92 coiled-coil domain containing 92 2.21089
TPD52L2 tumor protein D52-like 2 2.20034
SKIC8 SKI8 subunit of superkiller complex 2.18572
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.17867
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.17744
MCTP2 multiple C2 domains, transmembrane 2 2.1421
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.13367
CCN6 cellular communication network factor 6 2.12986
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.11501
MYO19 myosin XIX 2.09951
PNKP polynucleotide kinase 3'-phosphatase 2.07613
CEP192 centrosomal protein 192kDa 2.07035
MOK MOK protein kinase 2.06797
SYNGR3 synaptogyrin 3 2.05726
LAG3 lymphocyte-activation gene 3 2.02532
SIRT3 sirtuin 3 2.01814
ADAM20 ADAM metallopeptidase domain 20 2.00499

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.57349
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.68906
ADI1 acireductone dioxygenase 1 -5.95505
MRPS2 mitochondrial ribosomal protein S2 -4.87782
TLR4 toll-like receptor 4 -4.75441
CDC25B cell division cycle 25B -4.71032
ZNF586 zinc finger protein 586 -4.66222
OXA1L oxidase (cytochrome c) assembly 1-like -4.39421
UGDH UDP-glucose 6-dehydrogenase -4.15344
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.00734
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.99729
C2CD5 C2 calcium-dependent domain containing 5 -3.84341
TP53BP2 tumor protein p53 binding protein 2 -3.78921
NRIP1 nuclear receptor interacting protein 1 -3.24859
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.12359
GNAS GNAS complex locus -3.01626
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.82731
SLC35F2 solute carrier family 35, member F2 -2.72065
EIF5 eukaryotic translation initiation factor 5 -2.70799
FAIM Fas apoptotic inhibitory molecule -2.34598
HOXA5 homeobox A5 -2.23416
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.21347
USP3 ubiquitin specific peptidase 3 -2.15457
SDCBP syndecan binding protein (syntenin) -2.15084
MAPK13 mitogen-activated protein kinase 13 -2.1053
RBM15 RNA binding motif protein 15 -2.10366
UBA3 ubiquitin-like modifier activating enzyme 3 -2.08754
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.02693
SULT4A1 sulfotransferase family 4A, member 1 -2.02581
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.02394
UBE3C ubiquitin protein ligase E3C -2.02095