CRCGN009_HEPG2_24H:C12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrobenzene 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN009_HEPG2_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 7.0616
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.40656
MAP7 microtubule-associated protein 7 4.50254
GPATCH8 G patch domain containing 8 4.2684
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.18495
CBR3 carbonyl reductase 3 4.15171
SIRT3 sirtuin 3 3.84366
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.82494
SFTPB surfactant protein B 3.72457
CARMIL1 capping protein regulator and myosin 1 linker 1 3.71576
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.68555
CDPF1 cysteine-rich, DPF motif domain containing 1 3.54446
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.2889
CYCS cytochrome c, somatic 3.27788
SKIC8 SKI8 subunit of superkiller complex 3.23791
DIPK1A divergent protein kinase domain 1A 3.12424
SYNE2 spectrin repeat containing, nuclear envelope 2 3.04301
ICAM1 intercellular adhesion molecule 1 2.95466
AMDHD2 amidohydrolase domain containing 2 2.88681
PPARG peroxisome proliferator-activated receptor gamma 2.81222
HOXA10 homeobox A10 2.74521
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.67288
HLA-DMA major histocompatibility complex, class II, DM alpha 2.66714
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.65536
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.57568
E2F2 E2F transcription factor 2 2.52246
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.46003
ZFP36 ZFP36 ring finger protein 2.35949
EPN2 epsin 2 2.29808
RIC8A RIC8 guanine nucleotide exchange factor A 2.26964
CHN1 chimerin 1 2.25463
VGLL4 vestigial-like family member 4 2.221
GPER1 G protein-coupled estrogen receptor 1 2.16526
MEST mesoderm specific transcript 2.13298
ENOX1 ecto-NOX disulfide-thiol exchanger 1 2.13245
COL2A1 collagen, type II, alpha 1 2.09777
CCNF cyclin F 2.04091
ATP5MC3 ATP synthase membrane subunit c locus 3 2.03482
NINJ2 ninjurin 2 2.02995

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -6.76287
PCNA proliferating cell nuclear antigen -6.61616
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.43218
CDC25B cell division cycle 25B -4.24244
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.00977
DNM1L dynamin 1-like -3.80496
ZNF586 zinc finger protein 586 -3.75951
ZW10 zw10 kinetochore protein -3.60325
FBXL12 F-box and leucine-rich repeat protein 12 -3.4993
GOLT1B golgi transport 1B -3.47387
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.35428
OXA1L oxidase (cytochrome c) assembly 1-like -3.32573
LDHD lactate dehydrogenase D -3.2632
NCK1 NCK adaptor protein 1 -2.90743
CSK c-src tyrosine kinase -2.87014
EIF5 eukaryotic translation initiation factor 5 -2.86776
CCDC86 coiled-coil domain containing 86 -2.8083
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.77947
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.77318
ZDHHC6 zinc finger, DHHC-type containing 6 -2.53805
MAPK13 mitogen-activated protein kinase 13 -2.49147
HSPB1 heat shock 27kDa protein 1 -2.40567
CCNB2 cyclin B2 -2.38937
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.26113
FADD Fas (TNFRSF6)-associated via death domain -2.17419
C5 complement component 5 -2.08128
HMG20B high mobility group 20B -2.06507
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.02894