CRCGN009_HEPG2_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thioacetamide 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

309 genes differentially expressed following the CRCGN009_HEPG2_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.79206
ANO1 anoctamin 1, calcium activated chloride channel 7.58112
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.23047
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 6.64867
GPER1 G protein-coupled estrogen receptor 1 6.57723
HDGFL3 HDGF like 3 6.20669
TERT telomerase reverse transcriptase 5.25409
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.07773
MOK MOK protein kinase 5.04481
STIMATE STIM activating enhancer 4.99486
PLS1 plastin 1 4.97159
CCL2 chemokine (C-C motif) ligand 2 4.96652
CBR3 carbonyl reductase 3 4.95507
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.94704
HOXA10 homeobox A10 4.8854
MAMLD1 mastermind-like domain containing 1 4.87809
DYNLT3 dynein, light chain, Tctex-type 3 4.84251
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.82036
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.71553
PPARG peroxisome proliferator-activated receptor gamma 4.7127
ADRB2 adrenoceptor beta 2, surface 4.69478
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.69292
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.68836
GSTZ1 glutathione S-transferase zeta 1 4.67147
CHMP6 charged multivesicular body protein 6 4.6406
ADGRE5 adhesion G protein-coupled receptor E5 4.57731
LPAR2 lysophosphatidic acid receptor 2 4.46126
AXIN1 axin 1 4.42628
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.39709
TIAM1 T-cell lymphoma invasion and metastasis 1 4.21492
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.19789
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.19176
GARRE1 granule associated Rac and RHOG effector 1 4.09727
ZNF589 zinc finger protein 589 4.01974
CYCS cytochrome c, somatic 3.97259
EPHA3 EPH receptor A3 3.96561
CDPF1 cysteine-rich, DPF motif domain containing 1 3.78599
PEX11A peroxisomal biogenesis factor 11 alpha 3.72317
EPN2 epsin 2 3.59757
MAP7 microtubule-associated protein 7 3.51361
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.37735
IGFBP3 insulin-like growth factor binding protein 3 3.31369
PRKCH protein kinase C, eta 3.19997
GALR2 galanin receptor 2 3.11979
DENND2D DENN/MADD domain containing 2D 3.10759
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.07834
FZD7 frizzled class receptor 7 3.06529
ADRA1D adrenoceptor alpha 1D 3.0338
HTN3 histatin 3 3.01922
MYBPC2 myosin binding protein C, fast type 3.00094
FGF8 fibroblast growth factor 8 (androgen-induced) 2.99511
GPATCH8 G patch domain containing 8 2.97004
UTF1 undifferentiated embryonic cell transcription factor 1 2.94179
DIABLO diablo, IAP-binding mitochondrial protein 2.89308
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.89073
RRAGA Ras-related GTP binding A 2.86
PHF2 PHD finger protein 2 2.8214
GPR25 G protein-coupled receptor 25 2.79417
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.77711
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.77187
IRGC immunity-related GTPase family, cinema 2.76965
SHH sonic hedgehog 2.76396
NMUR1 neuromedin U receptor 1 2.75963
MATN2 matrilin 2 2.75092
INSL6 insulin-like 6 2.74409
ZFYVE21 zinc finger, FYVE domain containing 21 2.74372
SOX1 SRY (sex determining region Y)-box 1 2.66054
COL21A1 collagen, type XXI, alpha 1 2.65418
FN3K fructosamine 3 kinase 2.64005
SATB1 SATB homeobox 1 2.62908
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.61741
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.60427
FSCN2 fascin actin-bundling protein 2, retinal 2.59775
CHN1 chimerin 1 2.59477
SPATA6 spermatogenesis associated 6 2.59457
GPR68 G protein-coupled receptor 68 2.58857
LRRC3 leucine rich repeat containing 3 2.58353
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.58283
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.5737
PCDHGA11 protocadherin gamma subfamily A, 11 2.55101
KRT13 keratin 13, type I 2.54015
SOX30 SRY (sex determining region Y)-box 30 2.53911
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.53602
PLLP plasmolipin 2.53057
H4C7 H4 clustered histone 7 2.52103
CDX4 caudal type homeobox 4 2.49885
VSIG10 V-set and immunoglobulin domain containing 10 2.4925
UPP1 uridine phosphorylase 1 2.48816
AMDHD2 amidohydrolase domain containing 2 2.48185
FOXD3 forkhead box D3 2.47127
HOXD12 homeobox D12 2.43863
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.43663
COL19A1 collagen, type XIX, alpha 1 2.43246
SMR3B submaxillary gland androgen regulated protein 3B 2.42711
UPK1B uroplakin 1B 2.40468
NAP1L2 nucleosome assembly protein 1-like 2 2.39809
CCL1 chemokine (C-C motif) ligand 1 2.39804
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.39574
ZNF516 zinc finger protein 516 2.39198
HEBP1 heme binding protein 1 2.39055
CBARP CACN subunit beta associated regulatory protein 2.38883
FAM174B family with sequence similarity 174, member B 2.3846
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.38454
SCRT1 scratch family zinc finger 1 2.37756
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.37121
CNPY3 canopy FGF signaling regulator 3 2.36581
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.36373
FBXO24 F-box protein 24 2.3633
BCO1 beta-carotene oxygenase 1 2.36248
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.36114
MYH13 myosin, heavy chain 13, skeletal muscle 2.35921
CA10 carbonic anhydrase X 2.35481
OSR2 odd-skipped related transciption factor 2 2.35217
AIG1 androgen-induced 1 2.3372
CFAP44 cilia and flagella associated protein 44 2.33008
AMH anti-Mullerian hormone 2.32717
SSTR1 somatostatin receptor 1 2.32243
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.31747
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.31243
OMP olfactory marker protein 2.31198
CFAP46 cilia and flagella associated protein 46 2.30314
CDK4 cyclin-dependent kinase 4 2.30164
COQ8B coenzyme Q8B 2.2972
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.29656
WNT2B wingless-type MMTV integration site family, member 2B 2.28874
RASL10A RAS-like, family 10, member A 2.28057
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.27592
ZFP91 ZFP91 zinc finger protein 2.27249
LBX1 ladybird homeobox 1 2.27149
SGPL1 sphingosine-1-phosphate lyase 1 2.26797
RLN2 relaxin 2 2.26796
PSMC3IP PSMC3 interacting protein 2.266
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.2567
GPR63 G protein-coupled receptor 63 2.24732
FOXE1 forkhead box E1 2.24264
EMC10 ER membrane protein complex subunit 10 2.2363
LHX5 LIM homeobox 5 2.23386
DCAKD dephospho-CoA kinase domain containing 2.23079
ZNF343 zinc finger protein 343 2.22979
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.22871
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.22795
KERA keratocan 2.2266
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.22426
CCDC40 coiled-coil domain containing 40 2.22365
EDNRA endothelin receptor type A 2.22197
NKX2-8 NK2 homeobox 8 2.21717
ANGPTL7 angiopoietin-like 7 2.21415
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.21229
ADGRB1 adhesion G protein-coupled receptor B1 2.20771
CDH20 cadherin 20, type 2 2.20572
HOXD13 homeobox D13 2.20304
WNT1 wingless-type MMTV integration site family, member 1 2.20223
NEUROG3 neurogenin 3 2.2015
EIF5A2 eukaryotic translation initiation factor 5A2 2.1993
RAB31 RAB31, member RAS oncogene family 2.19703
RAD21L1 RAD21-like 1 (S. pombe) 2.19576
LMTK2 lemur tyrosine kinase 2 2.19527
RXFP3 relaxin/insulin-like family peptide receptor 3 2.19455
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.19303
HTN1 histatin 1 2.18337
CNTN6 contactin 6 2.18253
TRMT9B tRNA methyltransferase 9B (putative) 2.18197
PURG purine-rich element binding protein G 2.17389
SMR3A submaxillary gland androgen regulated protein 3A 2.17264
TBCCD1 TBCC domain containing 1 2.1707
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.1698
NPAS3 neuronal PAS domain protein 3 2.1692
FAM131A family with sequence similarity 131, member A 2.1606
ZMAT5 zinc finger, matrin-type 5 2.15304
SPATA2L spermatogenesis associated 2-like 2.15084
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.14936
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.14911
POU1F1 POU class 1 homeobox 1 2.14819
S100G S100 calcium binding protein G 2.14771
LEFTY2 left-right determination factor 2 2.14272
LCOR ligand dependent nuclear receptor corepressor 2.13847
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.13819
RAPSN receptor-associated protein of the synapse 2.1377
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.13735
CST4 cystatin S 2.13641
NPAS2 neuronal PAS domain protein 2 2.13627
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.13236
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.13133
DOT1L DOT1-like histone H3K79 methyltransferase 2.13096
NUP133 nucleoporin 133kDa 2.12452
RAB20 RAB20, member RAS oncogene family 2.12381
GPR137B G protein-coupled receptor 137B 2.12331
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.1232
SOX3 SRY (sex determining region Y)-box 3 2.12219
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.12066
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.11725
GUCY2F guanylate cyclase 2F, retinal 2.11495
EFHD2 EF-hand domain family, member D2 2.11324
TSPAN2 tetraspanin 2 2.10927
MYOM2 myomesin 2 2.10879
CRTAM cytotoxic and regulatory T cell molecule 2.10223
PRDM16 PR domain containing 16 2.10204
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.09891
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.09811
RORB RAR-related orphan receptor B 2.09694
DMRT1 doublesex and mab-3 related transcription factor 1 2.09694
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.09601
ZNF493 zinc finger protein 493 2.09297
LTC4S leukotriene C4 synthase 2.08995
NLGN4X neuroligin 4, X-linked 2.08972
FAAP20 FA core complex associated protein 20 2.08363
GRTP1 growth hormone regulated TBC protein 1 2.08181
AP4M1 adaptor-related protein complex 4, mu 1 subunit 2.07245
CCDC82 coiled-coil domain containing 82 2.07023
LGALS13 lectin, galactoside-binding, soluble, 13 2.06774
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.06678
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.06548
HOXB8 homeobox B8 2.06269
SELE selectin E 2.0618
NEU2 sialidase 2 (cytosolic sialidase) 2.05713
HYOU1 hypoxia up-regulated 1 2.05676
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.05048
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.05036
PAOX polyamine oxidase (exo-N4-amino) 2.04979
CLDN1 claudin 1 2.04979
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.04797
UPK3A uroplakin 3A 2.04705
MSH4 mutS homolog 4 2.0457
OPRD1 opioid receptor, delta 1 2.0453
MAGEL2 melanoma antigen family L2 2.04396
MTA2 metastasis associated 1 family, member 2 2.04382
PMP2 peripheral myelin protein 2 2.04368
PARPBP PARP1 binding protein 2.03659
LIN7A lin-7 homolog A (C. elegans) 2.03609
DNAH17 dynein, axonemal, heavy chain 17 2.03609
CRHR2 corticotropin releasing hormone receptor 2 2.02665
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.02583
LIM2 lens intrinsic membrane protein 2, 19kDa 2.02232
NTS neurotensin 2.02185
SLITRK2 SLIT and NTRK-like family, member 2 2.01949
VPS50 VPS50 subunit of EARP/GARPII complex 2.01915
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.01583
PLCE1 phospholipase C, epsilon 1 2.01496
CRYBA2 crystallin, beta A2 2.01395
ULBP2 UL16 binding protein 2 2.01125
HOXA11 homeobox A11 2.01057
NPY4R2 neuropeptide Y receptor Y4-2 2.00924
PPIAL4H peptidylprolyl isomerase A like 4H 2.00702
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.00564
LIN28A lin-28 homolog A (C. elegans) 2.00158
CER1 cerberus 1, DAN family BMP antagonist 2.00057
CATSPERG catsper channel auxiliary subunit gamma 2.00037
WNT7B wingless-type MMTV integration site family, member 7B 2.00018

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.80245
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.80968
GNAS GNAS complex locus -5.36908
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.35238
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.24491
UGDH UDP-glucose 6-dehydrogenase -5.12388
GOLT1B golgi transport 1B -5.09322
DSG2 desmoglein 2 -5.08335
CDC20 cell division cycle 20 -5.0
CD320 CD320 molecule -4.9289
LAP3 leucine aminopeptidase 3 -4.89972
TRIB3 tribbles pseudokinase 3 -4.89868
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.87735
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.83344
PCNA proliferating cell nuclear antigen -4.71304
CCNB2 cyclin B2 -4.67517
THAP11 THAP domain containing 11 -4.60619
ZMIZ1 zinc finger, MIZ-type containing 1 -4.45196
HAT1 histone acetyltransferase 1 -4.37547
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.17368
PGM1 phosphoglucomutase 1 -4.12191
DERA deoxyribose-phosphate aldolase (putative) -4.12186
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.07076
YME1L1 YME1-like 1 ATPase -3.94538
LOC124907782 dual specificity protein phosphatase 22 -3.73741
TLCD3A TLC domain containing 3A -3.46561
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.44888
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.37026
CSK c-src tyrosine kinase -3.3023
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.10268
CAB39 calcium binding protein 39 -2.8217
NRIP1 nuclear receptor interacting protein 1 -2.78741
DNM1L dynamin 1-like -2.73987
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.73659
SPATS2 spermatogenesis associated, serine-rich 2 -2.69783
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.66752
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.61591
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.58221
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.5614
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.55942
THAP12 THAP domain containing 12 -2.55016
LDHD lactate dehydrogenase D -2.53261
CEP170 centrosomal protein 170kDa -2.52493
ZW10 zw10 kinetochore protein -2.4818
FCHSD2 FCH and double SH3 domains 2 -2.41655
CCDC92 coiled-coil domain containing 92 -2.40987
CTNNBL1 catenin, beta like 1 -2.36487
HAUS3 HAUS augmin-like complex, subunit 3 -2.36082
DEFA6 defensin, alpha 6, Paneth cell-specific -2.35457
NELFCD negative elongation factor complex member C/D -2.32809
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.21493
RECQL RecQ helicase-like -2.20976
ITGB1BP1 integrin beta 1 binding protein 1 -2.20104
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.15249
TLR4 toll-like receptor 4 -2.10717
SLC38A2 solute carrier family 38, member 2 -2.09749
RTN4 reticulon 4 -2.04112
PPT2 palmitoyl-protein thioesterase 2 -2.03776
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.01736
LYN LYN proto-oncogene, Src family tyrosine kinase -2.01035
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.00181