CRCGN009_HEPG2_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN009_HEPG2_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.15263
LCN2 lipocalin 2 6.1488
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 5.74377
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.65704
CYCS cytochrome c, somatic 4.98366
MAP7 microtubule-associated protein 7 4.92691
FCHO1 FCH domain only 1 4.59702
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.43741
MAMLD1 mastermind-like domain containing 1 4.38712
TIAM1 T-cell lymphoma invasion and metastasis 1 4.35758
SYNE2 spectrin repeat containing, nuclear envelope 2 4.35278
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.23519
ADRB2 adrenoceptor beta 2, surface 4.21252
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.06843
STIMATE STIM activating enhancer 4.05649
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.95849
CHMP6 charged multivesicular body protein 6 3.95788
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.91464
E2F2 E2F transcription factor 2 3.91208
CAPN1 calpain 1, (mu/I) large subunit 3.69435
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.55151
RPL39L ribosomal protein L39-like 3.32056
MCM3 minichromosome maintenance complex component 3 3.29248
DNM1 dynamin 1 3.26244
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.17481
NFIL3 nuclear factor, interleukin 3 regulated 3.15607
NOTCH1 notch 1 3.11015
EPHA3 EPH receptor A3 3.10507
IGFBP3 insulin-like growth factor binding protein 3 2.85987
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.85689
GPER1 G protein-coupled estrogen receptor 1 2.84109
C2CD2 C2 calcium-dependent domain containing 2 2.82535
DIPK1A divergent protein kinase domain 1A 2.72239
NOSIP nitric oxide synthase interacting protein 2.71987
MYLK myosin light chain kinase 2.69164
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.66981
CBR1 carbonyl reductase 1 2.40453
KIF20A kinesin family member 20A 2.18886
NDC80 NDC80 kinetochore complex component 2.18361
TENT4A terminal nucleotidyltransferase 4A 2.17259
SMAD3 SMAD family member 3 2.12722
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.10942
CHN1 chimerin 1 2.10729
PRKCH protein kinase C, eta 2.02268
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.00388

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -6.56884
CCNB2 cyclin B2 -6.14158
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.95394
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.89987
RAI14 retinoic acid induced 14 -4.57722
LOC124907782 dual specificity protein phosphatase 22 -4.23052
UBE3C ubiquitin protein ligase E3C -3.98269
CCNB1 cyclin B1 -3.96077
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.46534
CDC25B cell division cycle 25B -3.44337
ZDHHC6 zinc finger, DHHC-type containing 6 -3.34615
MAPK13 mitogen-activated protein kinase 13 -3.17929
TCTN1 tectonic family member 1 -3.13864
ALDOC aldolase C, fructose-bisphosphate -3.05286
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.95557
CCDC85B coiled-coil domain containing 85B -2.95422
ZMIZ1 zinc finger, MIZ-type containing 1 -2.90831
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.90009
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.79185
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.73537
BPHL biphenyl hydrolase-like (serine hydrolase) -2.70454
WASHC4 WASH complex subunit 4 -2.64965
RFC2 replication factor C (activator 1) 2, 40kDa -2.57178
HEATR1 HEAT repeat containing 1 -2.40549
FAM174B family with sequence similarity 174, member B -2.39752
USP6NL USP6 N-terminal like -2.3261
PROS1 protein S (alpha) -2.16061
RIC8B RIC8 guanine nucleotide exchange factor B -2.1279
TLR4 toll-like receptor 4 -2.12463
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.11603
MTA1 metastasis associated 1 -2.06347
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.03919
GSTZ1 glutathione S-transferase zeta 1 -2.0119