CRCGN009_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN009_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.72973
RPL39L ribosomal protein L39-like 5.44949
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.23938
BACE2 beta-site APP-cleaving enzyme 2 5.10653
MOK MOK protein kinase 5.00953
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.65921
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.22298
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.90135
MYLK myosin light chain kinase 3.47504
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.46025
MEST mesoderm specific transcript 3.42068
TENT4A terminal nucleotidyltransferase 4A 3.18695
LOC122526780 uncharacterized LOC122526780 3.09312
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.05094
MAP7 microtubule-associated protein 7 3.03869
PMM2 phosphomannomutase 2 2.99563
CYCS cytochrome c, somatic 2.9405
LPAR2 lysophosphatidic acid receptor 2 2.90843
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.90425
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.68125
SHB Src homology 2 domain containing adaptor protein B 2.68123
ZNF589 zinc finger protein 589 2.60979
CHEK2 checkpoint kinase 2 2.60214
RRAGA Ras-related GTP binding A 2.58209
TBC1D31 TBC1 domain family, member 31 2.3411
CCL2 chemokine (C-C motif) ligand 2 2.2916
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.23884
TMEM242 transmembrane protein 242 2.15996
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.12345
GPATCH8 G patch domain containing 8 2.11831
DIPK1A divergent protein kinase domain 1A 2.09953
WASHC5 WASH complex subunit 5 2.07468
RAB21 RAB21, member RAS oncogene family 2.07467
CHN1 chimerin 1 2.03928
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.03122

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -5.17782
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.50066
NT5DC2 5'-nucleotidase domain containing 2 -4.43655
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.32369
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.22943
TLR4 toll-like receptor 4 -3.88418
MAPK13 mitogen-activated protein kinase 13 -3.84982
OXA1L oxidase (cytochrome c) assembly 1-like -3.56726
CCNB2 cyclin B2 -3.44075
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.38335
CCNB1 cyclin B1 -3.19769
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.11032
HMG20B high mobility group 20B -2.92909
SLC35F2 solute carrier family 35, member F2 -2.91676
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.71153
ILK integrin-linked kinase -2.61305
CXCL2 chemokine (C-X-C motif) ligand 2 -2.38758
TSKU tsukushi, small leucine rich proteoglycan -2.36118
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.17206
BIRC2 baculoviral IAP repeat containing 2 -2.15845
TRIM44 tripartite motif containing 44 -2.09991