CRCGN009_HEPG2_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN009_HEPG2_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 9.24596
ADO 2-aminoethanethiol (cysteamine) dioxygenase 6.18027
SQOR sulfide quinone oxidoreductase 5.04012
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.81061
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.73704
CIAO3 cytosolic iron-sulfur assembly component 3 4.59417
CBR3 carbonyl reductase 3 4.52841
CHN1 chimerin 1 4.52136
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.48437
EVL Enah/Vasp-like 4.0742
CCL2 chemokine (C-C motif) ligand 2 3.85538
MAP7 microtubule-associated protein 7 3.75405
SNAP25 synaptosomal-associated protein, 25kDa 3.71775
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.44806
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.42304
CYCS cytochrome c, somatic 3.2994
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.16813
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.15113
CCNF cyclin F 2.99176
MEST mesoderm specific transcript 2.94729
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.94304
PMM2 phosphomannomutase 2 2.8896
BAX BCL2-associated X protein 2.78017
LPAR2 lysophosphatidic acid receptor 2 2.69917
ISG15 ISG15 ubiquitin-like modifier 2.67656
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.66814
WDR7 WD repeat domain 7 2.54292
ADGRG1 adhesion G protein-coupled receptor G1 2.51576
SMIM40 small integral membrane protein 40 2.50422
IFI44L interferon-induced protein 44-like 2.49761
PRR15L proline rich 15-like 2.47519
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.38425
RSAD2 radical S-adenosyl methionine domain containing 2 2.38089
MX1 MX dynamin-like GTPase 1 2.36619
SATB1 SATB homeobox 1 2.28834
JADE2 jade family PHD finger 2 2.25217
SOCS2 suppressor of cytokine signaling 2 2.24925
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.15136
RIGI RNA sensor RIG-I 2.14125
USP18 ubiquitin specific peptidase 18 2.13076
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.10262

decreased expression

Symbol Name Standardized Value
HSPB1 heat shock 27kDa protein 1 -9.21029
TLR4 toll-like receptor 4 -5.15469
NRIP1 nuclear receptor interacting protein 1 -4.92117
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.67533
HLA-DMA major histocompatibility complex, class II, DM alpha -4.58739
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.55576
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.47164
PCCB propionyl CoA carboxylase, beta polypeptide -4.40305
CCNB1 cyclin B1 -4.35282
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.53102
CD58 CD58 molecule -3.37505
ZW10 zw10 kinetochore protein -3.08616
ZNF586 zinc finger protein 586 -2.98578
OXA1L oxidase (cytochrome c) assembly 1-like -2.94271
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.63276
TXNDC9 thioredoxin domain containing 9 -2.35994
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.3337
HMG20B high mobility group 20B -2.21717
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.17786
EIF5 eukaryotic translation initiation factor 5 -2.06992
ZMIZ1 zinc finger, MIZ-type containing 1 -2.03222