CRCGN009_HEPG2_24H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN009_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.05378
UBQLN2 ubiquilin 2 8.39718
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.88354
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.87919
RPP38 ribonuclease P/MRP 38kDa subunit 4.66387
CHMP6 charged multivesicular body protein 6 4.08912
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.02311
STIMATE STIM activating enhancer 3.96652
CCDC85B coiled-coil domain containing 85B 3.87369
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.83805
HEBP1 heme binding protein 1 3.77501
PLS1 plastin 1 3.55529
PPARG peroxisome proliferator-activated receptor gamma 3.46372
ZNF589 zinc finger protein 589 3.32764
NOTCH1 notch 1 3.15993
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.05678
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.92815
LPAR2 lysophosphatidic acid receptor 2 2.90143
UBE2A ubiquitin-conjugating enzyme E2A 2.84205
TIAM1 T-cell lymphoma invasion and metastasis 1 2.76036
TRAM2 translocation associated membrane protein 2 2.47425
GPATCH8 G patch domain containing 8 2.42187
CIRBP cold inducible RNA binding protein 2.35605
MCM3 minichromosome maintenance complex component 3 2.35231
PTK2 protein tyrosine kinase 2 2.22335
NOSIP nitric oxide synthase interacting protein 2.21148
GPER1 G protein-coupled estrogen receptor 1 2.17526
CBR3 carbonyl reductase 3 2.17291
TXK TXK tyrosine kinase 2.15665
FSD1 fibronectin type III and SPRY domain containing 1 2.04491
UPK1B uroplakin 1B 2.02808
GATA3 GATA binding protein 3 2.00994
TEX10 testis expressed 10 2.00604
FKBP3 FK506 binding protein 3, 25kDa 2.00429

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.53386
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -5.32076
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.26514
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.24199
VAT1 vesicle amine transport 1 -4.14582
TM9SF3 transmembrane 9 superfamily member 3 -4.08391
RGS2 regulator of G-protein signaling 2 -4.05461
NRIP1 nuclear receptor interacting protein 1 -3.99673
CCNB2 cyclin B2 -3.84682
HLA-DMA major histocompatibility complex, class II, DM alpha -3.69322
GNAS GNAS complex locus -3.52666
ANKRD10 ankyrin repeat domain 10 -3.29197
EGF epidermal growth factor -3.04742
PECR peroxisomal trans-2-enoyl-CoA reductase -2.99523
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.89026
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.79518
GLOD4 glyoxalase domain containing 4 -2.70071
ZNF586 zinc finger protein 586 -2.60499
CHIC2 cysteine-rich hydrophobic domain 2 -2.56606
MTMR12 myotubularin related protein 12 -2.48317
METTL16 methyltransferase like 16 -2.40585
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.34604
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.30279
CHKA choline kinase alpha -2.19424
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.06018
ATAD3A ATPase family, AAA domain containing 3A -2.05592
PEG10 paternally expressed 10 -2.05261
NPC1 Niemann-Pick disease, type C1 -2.04593
OXA1L oxidase (cytochrome c) assembly 1-like -2.01694
SLIT2 slit homolog 2 (Drosophila) -2.00654