CRCGN009_HEPG2_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.27735
FZD7 frizzled class receptor 7 5.16872
E2F2 E2F transcription factor 2 4.9371
CHMP6 charged multivesicular body protein 6 4.82134
MOK MOK protein kinase 4.74782
CYCS cytochrome c, somatic 3.88865
TIAM1 T-cell lymphoma invasion and metastasis 1 3.67426
STIMATE STIM activating enhancer 3.43485
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.25709
ZFP36 ZFP36 ring finger protein 3.18728
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.65411
LSR lipolysis stimulated lipoprotein receptor 2.60347
SFTPB surfactant protein B 2.52616
RPP38 ribonuclease P/MRP 38kDa subunit 2.39476
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.36078
VAV3 vav 3 guanine nucleotide exchange factor 2.34621
GATA2 GATA binding protein 2 2.29221
PPARG peroxisome proliferator-activated receptor gamma 2.27682
NOSIP nitric oxide synthase interacting protein 2.26545
ADGRE5 adhesion G protein-coupled receptor E5 2.20148
KIF20A kinesin family member 20A 2.07726
PYCR3 pyrroline-5-carboxylate reductase 3 2.01932
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.01846
LCN2 lipocalin 2 2.0078

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.40875
CDC20 cell division cycle 20 -5.0
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.84211
LDHD lactate dehydrogenase D -4.78089
TLCD3A TLC domain containing 3A -4.66961
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.666
TLR4 toll-like receptor 4 -3.82338
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.59747
RNF167 ring finger protein 167 -2.66541
HMG20B high mobility group 20B -2.62457
EGF epidermal growth factor -2.46318
NGRN neugrin, neurite outgrowth associated -2.3345
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.27494
PEG10 paternally expressed 10 -2.20769
ZNF586 zinc finger protein 586 -2.13297
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.11231
THAP11 THAP domain containing 11 -2.0551
BDKRB2 bradykinin receptor B2 -2.03608