CRCGN009_HEPG2_24H:D07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl carbamate 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN009_HEPG2_24H:D07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.61698
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.42211
ADRB2 adrenoceptor beta 2, surface 4.92916
GPER1 G protein-coupled estrogen receptor 1 4.81205
GSTZ1 glutathione S-transferase zeta 1 4.39961
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.04752
C2CD2 C2 calcium-dependent domain containing 2 4.02701
GPATCH8 G patch domain containing 8 3.92797
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.77886
CDC45 cell division cycle 45 3.74995
JADE2 jade family PHD finger 2 3.74294
CBR3 carbonyl reductase 3 3.47729
VAV3 vav 3 guanine nucleotide exchange factor 3.33257
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.3201
PEX11A peroxisomal biogenesis factor 11 alpha 3.30496
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.26433
ABHD6 abhydrolase domain containing 6 3.2279
ADGRE5 adhesion G protein-coupled receptor E5 3.12912
NOTCH1 notch 1 3.03969
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.02474
GATA2 GATA binding protein 2 2.9958
INTS3 integrator complex subunit 3 2.8609
DIPK1A divergent protein kinase domain 1A 2.85388
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.83632
TIAM1 T-cell lymphoma invasion and metastasis 1 2.80486
ANO10 anoctamin 10 2.79773
RPP38 ribonuclease P/MRP 38kDa subunit 2.79312
ETFDH electron-transferring-flavoprotein dehydrogenase 2.6262
EAPP E2F-associated phosphoprotein 2.60048
ICAM1 intercellular adhesion molecule 1 2.46851
CYCS cytochrome c, somatic 2.38022
CARMIL1 capping protein regulator and myosin 1 linker 1 2.32202
MYLK myosin light chain kinase 2.30965
GRM4 glutamate receptor, metabotropic 4 2.21909
GRAMD1C GRAM domain containing 1C 2.19198
CCNP cyclin P 2.16163
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.14938
CENPM centromere protein M 2.08423
NLRP2 NLR family, pyrin domain containing 2 2.08145
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.07929
VSIG2 V-set and immunoglobulin domain containing 2 2.07585
EXO1 exonuclease 1 2.06948
NUP133 nucleoporin 133kDa 2.05045
HLA-DMA major histocompatibility complex, class II, DM alpha 2.04878
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.04838
SYNPO2 synaptopodin 2 2.04081
AVPR1B arginine vasopressin receptor 1B 2.03797
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.03644
TMEM14A transmembrane protein 14A 2.02986
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.01918
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.01412
PRDM12 PR domain containing 12 2.01318
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.00699

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.58339
GNAS GNAS complex locus -7.45866
CDC20 cell division cycle 20 -6.98056
TRIB3 tribbles pseudokinase 3 -6.0664
SLC35F2 solute carrier family 35, member F2 -5.45008
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.72266
ARID5B AT rich interactive domain 5B (MRF1-like) -4.6845
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -4.36023
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.16537
MRPS2 mitochondrial ribosomal protein S2 -4.00115
OXA1L oxidase (cytochrome c) assembly 1-like -3.95627
ACOT9 acyl-CoA thioesterase 9 -3.87763
PCCB propionyl CoA carboxylase, beta polypeptide -3.6268
DNM1L dynamin 1-like -3.22457
HSPB1 heat shock 27kDa protein 1 -3.10503
CCDC86 coiled-coil domain containing 86 -3.06009
CDC25B cell division cycle 25B -3.02687
NRIP1 nuclear receptor interacting protein 1 -2.99246
PEG10 paternally expressed 10 -2.98709
LDHD lactate dehydrogenase D -2.9855
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.80397
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.78682
STAT1 signal transducer and activator of transcription 1, 91kDa -2.69051
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.64828
POMK protein-O-mannose kinase -2.62061
RFK riboflavin kinase -2.48024
ADI1 acireductone dioxygenase 1 -2.4764
PCNA proliferating cell nuclear antigen -2.46425
ZMYM6 zinc finger, MYM-type 6 -2.37598
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.3694
EXT1 exostosin glycosyltransferase 1 -2.30294
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.27985
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.24251
DCTN6 dynactin 6 -2.2268
CTNND1 catenin (cadherin-associated protein), delta 1 -2.11776
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.07421
TPX2 TPX2, microtubule-associated -2.07065
TMEM140 transmembrane protein 140 -2.06152
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.02414
FAF1 Fas (TNFRSF6) associated factor 1 -2.02336
FBXL2 F-box and leucine-rich repeat protein 2 -2.02153
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.00867