CRCGN009_HEPG2_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl carbamate 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

243 genes differentially expressed following the CRCGN009_HEPG2_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.50854
MAP7 microtubule-associated protein 7 7.44794
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.62666
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.39959
LCN2 lipocalin 2 6.00296
HOXA10 homeobox A10 5.99179
CYCS cytochrome c, somatic 5.93482
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.72526
RPL39L ribosomal protein L39-like 5.55351
RRAGA Ras-related GTP binding A 5.49811
E2F2 E2F transcription factor 2 5.44314
CAPN1 calpain 1, (mu/I) large subunit 5.23789
CBR3 carbonyl reductase 3 5.07223
OXCT1 3-oxoacid CoA transferase 1 4.84781
ADGRE5 adhesion G protein-coupled receptor E5 4.7332
GSTZ1 glutathione S-transferase zeta 1 4.71681
VGLL4 vestigial-like family member 4 4.47148
LAGE3 L antigen family, member 3 4.43082
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.42036
SYNE2 spectrin repeat containing, nuclear envelope 2 4.37755
INSIG1 insulin induced gene 1 4.31418
ALDOC aldolase C, fructose-bisphosphate 4.27429
C2CD2 C2 calcium-dependent domain containing 2 4.22854
LOXL1 lysyl oxidase-like 1 4.21233
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.1428
GPATCH8 G patch domain containing 8 4.14104
ADRB2 adrenoceptor beta 2, surface 4.07407
TAC4 tachykinin 4 (hemokinin) 3.97149
BACE2 beta-site APP-cleaving enzyme 2 3.94899
STK10 serine/threonine kinase 10 3.81417
EPHA3 EPH receptor A3 3.67192
CHMP6 charged multivesicular body protein 6 3.65798
CRTAP cartilage associated protein 3.5946
LSR lipolysis stimulated lipoprotein receptor 3.54211
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.51125
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.49233
CDK6 cyclin-dependent kinase 6 3.45014
SIRT3 sirtuin 3 3.43882
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.4252
TICAM1 toll-like receptor adaptor molecule 1 3.42257
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.39353
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.35752
OLFML2B olfactomedin-like 2B 3.2895
AMDHD2 amidohydrolase domain containing 2 3.2451
HOXA7 homeobox A7 3.22936
MEF2C myocyte enhancer factor 2C 3.22875
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.22437
EPHB2 EPH receptor B2 3.20358
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.10333
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 3.07943
DENND2D DENN/MADD domain containing 2D 3.02393
PCOLCE procollagen C-endopeptidase enhancer 3.0019
CEND1 cell cycle exit and neuronal differentiation 1 2.96867
ABHD6 abhydrolase domain containing 6 2.93528
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.91228
MMP3 matrix metallopeptidase 3 2.89435
LYRM1 LYR motif containing 1 2.83669
PARP1 poly (ADP-ribose) polymerase 1 2.82067
BTK Bruton agammaglobulinemia tyrosine kinase 2.81568
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.76036
TRAM2 translocation associated membrane protein 2 2.73615
HOOK2 hook microtubule-tethering protein 2 2.71519
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.70274
ARHGAP4 Rho GTPase activating protein 4 2.66443
CTSK cathepsin K 2.65437
PLS1 plastin 1 2.64255
FBLN2 fibulin 2 2.60099
EVA1B eva-1 homolog B (C. elegans) 2.58658
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.54488
CDX1 caudal type homeobox 1 2.53863
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.52661
CH25H cholesterol 25-hydroxylase 2.5069
NANOS3 nanos homolog 3 (Drosophila) 2.47627
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.47152
GPER1 G protein-coupled estrogen receptor 1 2.43155
DENR density-regulated protein 2.4055
MNMIP1 manchette microtubule inner protein 1 2.3985
SHH sonic hedgehog 2.37524
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.36438
ANGPTL2 angiopoietin-like 2 2.34885
NPY4R2 neuropeptide Y receptor Y4-2 2.32682
STX1A syntaxin 1A (brain) 2.32254
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.32168
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.32124
PRDM5 PR domain containing 5 2.31691
DEFB126 defensin, beta 126 2.30861
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.2997
CCNF cyclin F 2.28533
LIPC lipase, hepatic 2.28338
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.27319
LMTK2 lemur tyrosine kinase 2 2.26853
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.26259
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.25801
INTS3 integrator complex subunit 3 2.22112
SPINK4 serine peptidase inhibitor, Kazal type 4 2.21878
HLA-DMA major histocompatibility complex, class II, DM alpha 2.21695
CYBA cytochrome b-245, alpha polypeptide 2.20588
HEBP1 heme binding protein 1 2.18731
CD37 CD37 molecule 2.18285
HOXB9 homeobox B9 2.17997
CHN1 chimerin 1 2.17635
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.15472
FOCAD focadhesin 2.15179
GARRE1 granule associated Rac and RHOG effector 1 2.14757
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.14297
KLF13 Kruppel-like factor 13 2.14254
CEMIP2 cell migration inducing hyaluronidase 2 2.1373
ASL argininosuccinate lyase 2.13696
MIS18BP1 MIS18 binding protein 1 2.13396
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.13287
GJA3 gap junction protein, alpha 3, 46kDa 2.12707
CD81 CD81 molecule 2.12266
IL3RA interleukin 3 receptor, alpha (low affinity) 2.1164
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.11284
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.10606
CLCN2 chloride channel, voltage-sensitive 2 2.0996
SCT secretin 2.09348
NENF neudesin neurotrophic factor 2.09105
USP8 ubiquitin specific peptidase 8 2.08754
IGF2 insulin-like growth factor 2 2.08454
HSPB2 heat shock 27kDa protein 2 2.07813
BAG1 BCL2-associated athanogene 2.0746
SOCS2 suppressor of cytokine signaling 2 2.07124
PDGFD platelet derived growth factor D 2.0675
GDAP1 ganglioside induced differentiation associated protein 1 2.06529
MDM4 MDM4, p53 regulator 2.06264
RORB RAR-related orphan receptor B 2.06185
LMX1B LIM homeobox transcription factor 1, beta 2.05662
CYTH4 cytohesin 4 2.04962
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.04908
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.04279
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.03881
GLT8D2 glycosyltransferase 8 domain containing 2 2.03826
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.03145
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.03038
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.01724
POM121 POM121 transmembrane nucleoporin 2.01006
KANK2 KN motif and ankyrin repeat domains 2 2.00798
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.00675
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.00584
SNED1 sushi, nidogen and EGF-like domains 1 2.00255

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.3817
THAP11 THAP domain containing 11 -6.60036
SLC35F2 solute carrier family 35, member F2 -5.32452
CAB39 calcium binding protein 39 -5.13643
ZNF586 zinc finger protein 586 -5.12881
AKAP8 A kinase (PRKA) anchor protein 8 -4.7662
NGRN neugrin, neurite outgrowth associated -4.74047
GOLT1B golgi transport 1B -4.2213
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.07796
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.99954
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.9635
ADI1 acireductone dioxygenase 1 -3.94498
LOC124907782 dual specificity protein phosphatase 22 -3.86556
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.81874
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.75454
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.64676
RGS2 regulator of G-protein signaling 2 -3.59359
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.44881
DSG2 desmoglein 2 -3.44196
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.41217
TOR1A torsin family 1, member A (torsin A) -3.37643
COG7 component of oligomeric golgi complex 7 -3.23585
ZW10 zw10 kinetochore protein -3.14256
CCNB2 cyclin B2 -3.06169
DYNLT3 dynein, light chain, Tctex-type 3 -3.01359
ZNF175 zinc finger protein 175 -2.95965
RNPS1 RNA binding protein S1, serine-rich domain -2.91528
GTPBP8 GTP-binding protein 8 (putative) -2.81578
TSPOAP1 TSPO associated protein 1 -2.78896
EGF epidermal growth factor -2.74976
GHR growth hormone receptor -2.74724
NCOA4 nuclear receptor coactivator 4 -2.73614
TM9SF3 transmembrane 9 superfamily member 3 -2.72086
ZNF263 zinc finger protein 263 -2.71342
ZNF580 zinc finger protein 580 -2.61729
KDM3A lysine (K)-specific demethylase 3A -2.57374
EIF2D eukaryotic translation initiation factor 2D -2.53641
RHOT1 ras homolog family member T1 -2.51926
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.49456
SH3GL1 SH3-domain GRB2-like 1 -2.45931
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.45291
METTL25B methyltransferase like 25B -2.4492
ACTL8 actin-like 8 -2.4317
TEAD3 TEA domain family member 3 -2.42786
CDK20 cyclin-dependent kinase 20 -2.41653
TLR4 toll-like receptor 4 -2.39912
RAI1 retinoic acid induced 1 -2.38045
HIRIP3 HIRA interacting protein 3 -2.37867
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.37593
PANK4 pantothenate kinase 4 -2.36428
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.35716
ZC3H7A zinc finger CCCH-type containing 7A -2.35438
ADAM9 ADAM metallopeptidase domain 9 -2.35387
CDCP1 CUB domain containing protein 1 -2.3487
USP6NL USP6 N-terminal like -2.3304
PDE8B phosphodiesterase 8B -2.31565
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.31399
FBXL12 F-box and leucine-rich repeat protein 12 -2.30631
BIRC2 baculoviral IAP repeat containing 2 -2.28188
FAM32A family with sequence similarity 32, member A -2.26137
SAE1 SUMO1 activating enzyme subunit 1 -2.24685
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.2344
ZNF432 zinc finger protein 432 -2.21877
EIF5 eukaryotic translation initiation factor 5 -2.2156
GLOD4 glyoxalase domain containing 4 -2.21379
RPAP2 RNA polymerase II associated protein 2 -2.20272
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.19514
TCEAL4 transcription elongation factor A (SII)-like 4 -2.19105
NXT1 nuclear transport factor 2-like export factor 1 -2.19077
ATAD2B ATPase family, AAA domain containing 2B -2.1845
PPOX protoporphyrinogen oxidase -2.17386
ZNF304 zinc finger protein 304 -2.16674
FHL2 four and a half LIM domains 2 -2.16104
HYOU1 hypoxia up-regulated 1 -2.16065
CRYGD crystallin, gamma D -2.13686
TMEM123 transmembrane protein 123 -2.1352
NOP53 NOP53 ribosome biogenesis factor -2.13475
SKIC2 SKI2 subunit of superkiller complex -2.12788
AK4 adenylate kinase 4 -2.11242
PDGFC platelet derived growth factor C -2.109
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.10794
CENPM centromere protein M -2.10371
ZNF7 zinc finger protein 7 -2.09912
TMEM230 transmembrane protein 230 -2.09754
TCTN1 tectonic family member 1 -2.09582
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.09558
FBXW11 F-box and WD repeat domain containing 11 -2.09309
MRPL18 mitochondrial ribosomal protein L18 -2.08809
ZNF665 zinc finger protein 665 -2.08506
TRIM13 tripartite motif containing 13 -2.07502
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.07426
PRCP prolylcarboxypeptidase (angiotensinase C) -2.06147
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.05817
NEK7 NIMA-related kinase 7 -2.04492
INSIG2 insulin induced gene 2 -2.03632
MCOLN1 mucolipin 1 -2.03144
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.02342
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.01629
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -2.00715
MPHOSPH6 M-phase phosphoprotein 6 -2.00558
DCK deoxycytidine kinase -2.00428
FN1 fibronectin 1 -2.00222