CRCGN009_HEPG2_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl carbamate 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.82904
TIAM1 T-cell lymphoma invasion and metastasis 1 4.355
CHMP6 charged multivesicular body protein 6 3.97262
CBR3 carbonyl reductase 3 3.94323
RPP38 ribonuclease P/MRP 38kDa subunit 3.82672
MAMLD1 mastermind-like domain containing 1 3.734
LCN2 lipocalin 2 3.63209
LOC122526780 uncharacterized LOC122526780 3.31183
GPER1 G protein-coupled estrogen receptor 1 3.29751
PPARG peroxisome proliferator-activated receptor gamma 3.23088
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.16596
CYCS cytochrome c, somatic 2.85103
UBQLN2 ubiquilin 2 2.71089
MAP7 microtubule-associated protein 7 2.54104
KIF20A kinesin family member 20A 2.50988
GPATCH8 G patch domain containing 8 2.17315
CHN1 chimerin 1 2.14736
COMMD10 COMM domain containing 10 2.12566
PCDHB11 protocadherin beta 11 2.0797
GSTZ1 glutathione S-transferase zeta 1 2.05939

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.67287
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.93234
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.50385
CCNB2 cyclin B2 -4.26436
CCDC86 coiled-coil domain containing 86 -3.69886
DNM1L dynamin 1-like -3.64673
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.45998
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.33055
CTSD cathepsin D -3.31026
RAI14 retinoic acid induced 14 -3.26391
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.1725
EIF5 eukaryotic translation initiation factor 5 -3.03642
PEG10 paternally expressed 10 -2.98753
RPN1 ribophorin I -2.87018
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.59498
GOLT1B golgi transport 1B -2.48112
TES testin LIM domain protein -2.44624
GTPBP8 GTP-binding protein 8 (putative) -2.39943
GPR87 G protein-coupled receptor 87 -2.22246
YME1L1 YME1-like 1 ATPase -2.17138
MVP major vault protein -2.16572
GNAS GNAS complex locus -2.01661