CRCGN009_HEPG2_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN009_HEPG2_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.48547
E2F2 E2F transcription factor 2 7.14936
RPL39L ribosomal protein L39-like 3.94583
C2CD2 C2 calcium-dependent domain containing 2 3.72047
CCNF cyclin F 3.69337
ATP11B ATPase, class VI, type 11B 3.63132
CHN1 chimerin 1 3.58461
RPP38 ribonuclease P/MRP 38kDa subunit 3.58251
GSTZ1 glutathione S-transferase zeta 1 3.35752
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.29011
MEF2C myocyte enhancer factor 2C 3.28687
BLMH bleomycin hydrolase 3.26599
PPARG peroxisome proliferator-activated receptor gamma 3.12422
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.89576
MAMLD1 mastermind-like domain containing 1 2.7802
KIFBP kinesin family binding protein 2.71031
CXCL2 chemokine (C-X-C motif) ligand 2 2.6004
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.59782
ADAM10 ADAM metallopeptidase domain 10 2.51862
MTA2 metastasis associated 1 family, member 2 2.2637
TIAM1 T-cell lymphoma invasion and metastasis 1 2.26032
FCHO1 FCH domain only 1 2.2334
JADE2 jade family PHD finger 2 2.14457
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.14417
CEP57 centrosomal protein 57kDa 2.06904
SQOR sulfide quinone oxidoreductase 2.05022
HEBP1 heme binding protein 1 2.00224

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.2608
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.65256
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.58504
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.49155
TLR4 toll-like receptor 4 -5.5655
NT5DC2 5'-nucleotidase domain containing 2 -4.16789
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.48305
ISOC1 isochorismatase domain containing 1 -3.41169
LDHD lactate dehydrogenase D -3.36194
ZNF586 zinc finger protein 586 -3.18992
PCNA proliferating cell nuclear antigen -3.11116
EIF5 eukaryotic translation initiation factor 5 -2.93196
TM9SF3 transmembrane 9 superfamily member 3 -2.76668
TLCD3A TLC domain containing 3A -2.74659
CCNB1 cyclin B1 -2.69225
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.52347
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.46244
PTPRK protein tyrosine phosphatase, receptor type, K -2.38463
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.37812
REEP5 receptor accessory protein 5 -2.16281
GOLGA4 golgin A4 -2.08021