CRCGN009_HEPG2_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 10.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.16921
STK10 serine/threonine kinase 10 5.37626
GSTZ1 glutathione S-transferase zeta 1 5.21682
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.49141
CCNF cyclin F 4.31385
TIAM1 T-cell lymphoma invasion and metastasis 1 4.10818
MAMLD1 mastermind-like domain containing 1 3.5922
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.54901
NOTCH1 notch 1 3.39652
SIRT3 sirtuin 3 3.28099
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.08296
PPARG peroxisome proliferator-activated receptor gamma 2.97154
UBQLN2 ubiquilin 2 2.8765
DIPK1A divergent protein kinase domain 1A 2.81909
KIF20A kinesin family member 20A 2.79835
JADE2 jade family PHD finger 2 2.4526
KDM5A lysine (K)-specific demethylase 5A 2.38149
CCDC85B coiled-coil domain containing 85B 2.37337
CYCS cytochrome c, somatic 2.316
STYXL1 serine/threonine/tyrosine interacting-like 1 2.11981
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.09622
KIF3A kinesin family member 3A 2.02227
LOC122526780 uncharacterized LOC122526780 2.01682

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.98813
MAPK13 mitogen-activated protein kinase 13 -4.29422
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.20358
TRIB3 tribbles pseudokinase 3 -4.06822
DNM1L dynamin 1-like -3.96523
PCNA proliferating cell nuclear antigen -3.74652
KDM3A lysine (K)-specific demethylase 3A -3.48362
LOC124907782 dual specificity protein phosphatase 22 -3.42614
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.29402
TLR4 toll-like receptor 4 -3.18746
EGF epidermal growth factor -3.13295
FBXL12 F-box and leucine-rich repeat protein 12 -2.88297
RNF167 ring finger protein 167 -2.64731
ADI1 acireductone dioxygenase 1 -2.64167
CCDC86 coiled-coil domain containing 86 -2.53235
CCNB2 cyclin B2 -2.25843
DEPP1 DEPP autophagy regulator 1 -2.25469
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.18976
NRIP1 nuclear receptor interacting protein 1 -2.09929