CRCGN009_HEPG2_24H:D16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 5.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:D16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.74745
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.98461
BACE2 beta-site APP-cleaving enzyme 2 4.95259
AMDHD2 amidohydrolase domain containing 2 4.79812
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.72679
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.72525
STK10 serine/threonine kinase 10 4.66351
STAP2 signal transducing adaptor family member 2 4.65861
PPARG peroxisome proliferator-activated receptor gamma 4.64143
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.62436
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.49642
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.49351
NOTCH1 notch 1 4.29589
DIPK1A divergent protein kinase domain 1A 4.24201
MYLK myosin light chain kinase 4.19923
C2CD2 C2 calcium-dependent domain containing 2 4.10281
HLA-DMA major histocompatibility complex, class II, DM alpha 3.99082
CXCL2 chemokine (C-X-C motif) ligand 2 3.7586
CYCS cytochrome c, somatic 3.56705
GPATCH8 G patch domain containing 8 2.90313
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.88564
SCRN1 secernin 1 2.82999
SOCS2 suppressor of cytokine signaling 2 2.81456
LCN2 lipocalin 2 2.80463
PRR15L proline rich 15-like 2.61469
ABHD6 abhydrolase domain containing 6 2.58582
CHN1 chimerin 1 2.53885
CEP57 centrosomal protein 57kDa 2.43124
ACOT2 acyl-CoA thioesterase 2 2.35738
ANO1 anoctamin 1, calcium activated chloride channel 2.31267
CAPN3 calpain 3, (p94) 2.12651
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.09443
BANP BTG3 associated nuclear protein 2.08998
CEMIP2 cell migration inducing hyaluronidase 2 2.01416
CCL21 chemokine (C-C motif) ligand 21 2.00927

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.06174
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.982
FASTKD5 FAST kinase domains 5 -4.75498
UGDH UDP-glucose 6-dehydrogenase -4.72786
LDHD lactate dehydrogenase D -4.72631
MRPS2 mitochondrial ribosomal protein S2 -4.70534
TLR4 toll-like receptor 4 -4.18928
SNX11 sorting nexin 11 -3.94344
DSG2 desmoglein 2 -3.8967
ENOPH1 enolase-phosphatase 1 -3.85824
FGFR4 fibroblast growth factor receptor 4 -3.73205
MAPK13 mitogen-activated protein kinase 13 -3.43189
CSK c-src tyrosine kinase -3.32548
RFC2 replication factor C (activator 1) 2, 40kDa -2.97624
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.60948
PRPF4 pre-mRNA processing factor 4 -2.4796
FBXL12 F-box and leucine-rich repeat protein 12 -2.43069
ITGB1BP1 integrin beta 1 binding protein 1 -2.37506
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.31317
FAT1 FAT atypical cadherin 1 -2.26494
GRB2 growth factor receptor-bound protein 2 -2.2362
TLCD3A TLC domain containing 3A -2.20242
CRELD2 cysteine-rich with EGF-like domains 2 -2.19538
R3HCC1 R3H domain and coiled-coil containing 1 -2.11943
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.06787