| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | acrolein 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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61 genes differentially expressed following the CRCGN009_HEPG2_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 6.42254 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.25782 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.70075 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 5.10838 |
| CBR3 | carbonyl reductase 3 | 5.06188 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.0311 |
| MAP7 | microtubule-associated protein 7 | 5.01355 |
| ADRB2 | adrenoceptor beta 2, surface | 4.86183 |
| MOK | MOK protein kinase | 4.72193 |
| TAC4 | tachykinin 4 (hemokinin) | 4.56874 |
| MAMLD1 | mastermind-like domain containing 1 | 4.5205 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 4.34654 |
| UBQLN2 | ubiquilin 2 | 4.31373 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.24655 |
| CYCS | cytochrome c, somatic | 4.20064 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.67747 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.043 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.72456 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.68454 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.66688 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.6035 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.54105 |
| CCNF | cyclin F | 2.53781 |
| NOSIP | nitric oxide synthase interacting protein | 2.40776 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | 2.40131 |
| SIRT3 | sirtuin 3 | 2.37991 |
| GATA2 | GATA binding protein 2 | 2.37921 |
| SQOR | sulfide quinone oxidoreductase | 2.31686 |
| MMP1 | matrix metallopeptidase 1 | 2.30911 |
| PLSCR3 | phospholipid scramblase 3 | 2.30617 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.22861 |
| EVL | Enah/Vasp-like | 2.0111 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -7.8391 |
| PCNA | proliferating cell nuclear antigen | -6.4761 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -6.43632 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.80215 |
| LDHD | lactate dehydrogenase D | -5.01722 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.85137 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -4.84872 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -4.59127 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -4.25989 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -4.11711 |
| CCNB2 | cyclin B2 | -3.94643 |
| RAI14 | retinoic acid induced 14 | -3.53692 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.22537 |
| CCNB1 | cyclin B1 | -3.14166 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.06361 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.03265 |
| CSK | c-src tyrosine kinase | -2.9381 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.88299 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.5865 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.42067 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.34295 |
| WASHC4 | WASH complex subunit 4 | -2.20389 |
| SLC35F2 | solute carrier family 35, member F2 | -2.15808 |
| SNX11 | sorting nexin 11 | -2.15286 |
| PCDH12 | protocadherin 12 | -2.08483 |
| HSPA12A | heat shock 70kDa protein 12A | -2.0629 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.03759 |
| FCGBP | Fc fragment of IgG binding protein | -2.02631 |
