CRCGN009_HEPG2_24H:D19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:D19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 6.6615
DYNLT3 dynein, light chain, Tctex-type 3 5.13157
CCNF cyclin F 5.02357
CCL2 chemokine (C-C motif) ligand 2 4.97475
ATP11B ATPase, class VI, type 11B 4.84341
ZNF589 zinc finger protein 589 4.13079
RAB21 RAB21, member RAS oncogene family 4.00371
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.85357
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.8057
CHN1 chimerin 1 3.77697
E2F2 E2F transcription factor 2 3.71882
PNKP polynucleotide kinase 3'-phosphatase 3.58058
CHMP6 charged multivesicular body protein 6 3.49598
HOXA10 homeobox A10 3.27145
MEST mesoderm specific transcript 3.20301
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.18325
PLSCR1 phospholipid scramblase 1 3.09859
STK10 serine/threonine kinase 10 3.08034
TIAM1 T-cell lymphoma invasion and metastasis 1 3.07946
CYCS cytochrome c, somatic 2.8068
EDN1 endothelin 1 2.79428
ABHD6 abhydrolase domain containing 6 2.74819
HLA-DMA major histocompatibility complex, class II, DM alpha 2.72035
GPER1 G protein-coupled estrogen receptor 1 2.69711
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.61755
DIPK1A divergent protein kinase domain 1A 2.61062
POGLUT2 protein O-glucosyltransferase 2 2.54243
TPD52L2 tumor protein D52-like 2 2.46782
OXCT1 3-oxoacid CoA transferase 1 2.43929
COL4A1 collagen, type IV, alpha 1 2.41867
NOTCH1 notch 1 2.41028
KIF20A kinesin family member 20A 2.40375
ADRB2 adrenoceptor beta 2, surface 2.34115
JADE2 jade family PHD finger 2 2.26505
NLGN1 neuroligin 1 2.24307
ABHD4 abhydrolase domain containing 4 2.15543
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.05657
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.00466

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -6.59604
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.19744
CCNB1 cyclin B1 -5.62709
CCNB2 cyclin B2 -5.6046
GTPBP8 GTP-binding protein 8 (putative) -4.50853
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.33321
UGDH UDP-glucose 6-dehydrogenase -3.58389
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.58278
LDHD lactate dehydrogenase D -3.45315
DUSP6 dual specificity phosphatase 6 -3.41357
VDAC1 voltage-dependent anion channel 1 -3.21195
VAT1 vesicle amine transport 1 -3.14442
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.0843
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.85706
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.84954
EGF epidermal growth factor -2.71704
SPAG4 sperm associated antigen 4 -2.40582
TUBB6 tubulin, beta 6 class V -2.2342
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.20133
ZDHHC6 zinc finger, DHHC-type containing 6 -2.1521
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.08739
NT5DC2 5'-nucleotidase domain containing 2 -2.00599