CRCGN009_HEPG2_24H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN009_HEPG2_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.47613
STIMATE STIM activating enhancer 6.05942
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.52652
NOTCH1 notch 1 4.21273
GPER1 G protein-coupled estrogen receptor 1 3.8126
MAMLD1 mastermind-like domain containing 1 3.57003
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.4948
CRTAP cartilage associated protein 3.42871
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.24603
CIAO3 cytosolic iron-sulfur assembly component 3 3.21002
E2F2 E2F transcription factor 2 3.0426
CHMP6 charged multivesicular body protein 6 3.02151
DDB2 damage-specific DNA binding protein 2, 48kDa 3.00977
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.99017
SFTPB surfactant protein B 2.9753
MAP7 microtubule-associated protein 7 2.9312
CHN1 chimerin 1 2.84193
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.80765
CBR3 carbonyl reductase 3 2.76786
CYCS cytochrome c, somatic 2.74015
ADRB2 adrenoceptor beta 2, surface 2.69417
SNAP25 synaptosomal-associated protein, 25kDa 2.64752
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.60172
EVL Enah/Vasp-like 2.56778
GAA glucosidase, alpha; acid 2.50057
DIPK1A divergent protein kinase domain 1A 2.48723
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.41883
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.29847
TUBB6 tubulin, beta 6 class V 2.23119
NUCB2 nucleobindin 2 2.20796
BAMBI BMP and activin membrane-bound inhibitor 2.20211
IDE insulin-degrading enzyme 2.1189
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.11123
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.07586
MICA MHC class I polypeptide-related sequence A 2.0658
SMAD3 SMAD family member 3 2.06202
ZFYVE21 zinc finger, FYVE domain containing 21 2.04445
CDC25B cell division cycle 25B 2.02607
MVP major vault protein 2.02202
SOX3 SRY (sex determining region Y)-box 3 2.00268

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.78349
PCNA proliferating cell nuclear antigen -6.36758
ZNF586 zinc finger protein 586 -5.62869
ZW10 zw10 kinetochore protein -5.06475
HMG20B high mobility group 20B -4.55371
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.80596
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.78731
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.42993
RPIA ribose 5-phosphate isomerase A -3.28976
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.21982
CHERP calcium homeostasis endoplasmic reticulum protein -3.19929
ADI1 acireductone dioxygenase 1 -2.74675
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.73147
EIF5 eukaryotic translation initiation factor 5 -2.68158
CD320 CD320 molecule -2.63677
TCERG1 transcription elongation regulator 1 -2.59881
ENOPH1 enolase-phosphatase 1 -2.58203
ZNF587B zinc finger protein 587B -2.52231
RFC2 replication factor C (activator 1) 2, 40kDa -2.50621
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.46847
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.42875
DPH2 DPH2 homolog (S. cerevisiae) -2.40549
MYL9 myosin, light chain 9, regulatory -2.32111
RBM7 RNA binding motif protein 7 -2.27568
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.21998
TCTN1 tectonic family member 1 -2.07659
NUP62 nucleoporin 62kDa -2.07141
HYOU1 hypoxia up-regulated 1 -2.06604
BIRC2 baculoviral IAP repeat containing 2 -2.00365