CRCGN009_HEPG2_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN009_HEPG2_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 5.48283
RPP38 ribonuclease P/MRP 38kDa subunit 5.26188
CBR3 carbonyl reductase 3 4.96738
PRR15L proline rich 15-like 4.89164
STK10 serine/threonine kinase 10 4.70797
STIMATE STIM activating enhancer 4.65143
E2F2 E2F transcription factor 2 4.6495
UBQLN2 ubiquilin 2 4.5942
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.49746
CARMIL1 capping protein regulator and myosin 1 linker 1 4.23751
HOXA10 homeobox A10 4.1341
ANO1 anoctamin 1, calcium activated chloride channel 4.12739
IDE insulin-degrading enzyme 3.89943
PFKL phosphofructokinase, liver 3.41638
LCN2 lipocalin 2 3.39078
CCL2 chemokine (C-C motif) ligand 2 3.35196
ABHD4 abhydrolase domain containing 4 3.34615
STXBP2 syntaxin binding protein 2 3.28362
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.18882
GSTZ1 glutathione S-transferase zeta 1 3.17416
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.9821
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.94403
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.92232
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.75816
MAMLD1 mastermind-like domain containing 1 2.58042
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.54981
HOXC11 homeobox C11 2.4785
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.47743
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.45439
CHEK2 checkpoint kinase 2 2.36815
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.30047
NLRP2B NLR family pyrin domain containing 2B 2.24901
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.23697
PARK7 parkinson protein 7 2.21882
PRB4 proline-rich protein BstNI subfamily 4 2.17545
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.12826
SLC38A4 solute carrier family 38, member 4 2.11139
RPLP0 ribosomal protein, large, P0 2.10107
TROAP trophinin associated protein 2.08096
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.07674
KLHL9 kelch-like family member 9 2.07292
MOSPD2 motile sperm domain containing 2 2.0309
JTB jumping translocation breakpoint 2.01704
RPS27L ribosomal protein S27-like 2.01312
TRAM2 translocation associated membrane protein 2 2.00926

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -9.56221
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.71053
LDHD lactate dehydrogenase D -5.27457
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.27281
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.98953
TRIB3 tribbles pseudokinase 3 -4.62752
ADI1 acireductone dioxygenase 1 -4.55469
TUBB6 tubulin, beta 6 class V -4.54901
CDC20 cell division cycle 20 -4.45337
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.21369
MAPK13 mitogen-activated protein kinase 13 -3.82417
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.70879
CSK c-src tyrosine kinase -3.50824
OXA1L oxidase (cytochrome c) assembly 1-like -3.21396
RAI14 retinoic acid induced 14 -2.96873
TLCD3A TLC domain containing 3A -2.96054
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.94483
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.92523
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.72009
ILK integrin-linked kinase -2.55431
TXNDC9 thioredoxin domain containing 9 -2.45617
ACLY ATP citrate lyase -2.2737
EPS8L2 EPS8-like 2 -2.10734
GET1 guided entry of tail-anchored proteins factor 1 -2.10155
ESYT1 extended synaptotagmin-like protein 1 -2.09694
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.07813
CCL3L3 chemokine (C-C motif) ligand 3-like 3 -2.04385
HMOX1 heme oxygenase 1 -2.02883
PGM1 phosphoglucomutase 1 -2.01318