CRCGN009_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN009_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 5.00153
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.787
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.64457
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.50674
SNAP25 synaptosomal-associated protein, 25kDa 3.95805
HOXA10 homeobox A10 3.93586
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.69608
DIPK1A divergent protein kinase domain 1A 3.62142
VAV3 vav 3 guanine nucleotide exchange factor 3.3489
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.04269
HLA-DRA major histocompatibility complex, class II, DR alpha 2.9262
VGLL4 vestigial-like family member 4 2.9015
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.56411
KIF20A kinesin family member 20A 2.4625
FPGS folylpolyglutamate synthase 2.35553
TIAM1 T-cell lymphoma invasion and metastasis 1 2.33523
ZNF589 zinc finger protein 589 2.28762
NLRP2B NLR family pyrin domain containing 2B 2.21974
JADE2 jade family PHD finger 2 2.02763

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -4.88989
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.74169
DSG2 desmoglein 2 -4.64577
PCNA proliferating cell nuclear antigen -4.63954
CCNB2 cyclin B2 -4.60716
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.5644
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.48045
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.46304
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.42298
VAT1 vesicle amine transport 1 -4.19505
ADI1 acireductone dioxygenase 1 -4.17858
LDHD lactate dehydrogenase D -4.10159
ZNF586 zinc finger protein 586 -3.58601
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.58512
CCNB1 cyclin B1 -3.27678
UBE3C ubiquitin protein ligase E3C -3.21043
ZMIZ1 zinc finger, MIZ-type containing 1 -2.87634
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.75321
DCK deoxycytidine kinase -2.63319
DDIT4 DNA-damage-inducible transcript 4 -2.33668
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2798
ITGB1BP1 integrin beta 1 binding protein 1 -2.15273
NRIP1 nuclear receptor interacting protein 1 -2.0762
CRELD2 cysteine-rich with EGF-like domains 2 -2.0379